Remember, your liver is dumping up to 90 %
of the oral progesterone before it even gets into your cells, so you may only be getting 10 mg, which may not enough to oppose that amount of estrogen.
It should be noted that 300 mg
of oral progesterone is a very high dose, and doctors in the U.S. who use bioidentical hormones tend to use the standard 200 mg dose of Prometrium.
Not exact matches
Study participants were randomly assigned to one
of three treatment groups for six months: (1)
oral estradiol and
progesterone at a dose similar to that in many birth control pills (16 participants); (2) transdermal estradiol, better known as the estrogen patch, at a physiological replacement dose with cyclic
progesterone (13 athletes); or (3) no estrogen (19 subjects).
While
oral medications are still an option, we've found topicals (gels and creams) to be the most effective for estrogen and
progesterone replacement, and injections are best for administering consistent doses
of supplemental testosterone.
Based on current data, I prefer to prescribe FDA - approved forms
of bioidentical hormones, particularly the estradiol skin patch and
oral micronized
progesterone (Prometrium) pills.
When I counsel a woman about taking hormone therapy, I recommend bioidentical estrogen and
progesterone, including transdermal estradiol and
oral progesterone, but with an important caveat: I assume that the risks
of bioidentical hormone therapy are the same as synthetic until proven otherwise.
I believe in the lowest possible doses
of FDA - approved and regulated transdermal estrogen balanced with
oral progesterone, if you have a uterus.
Differential effects
of oral and transdermal estrogen /
progesterone regimens on sensitivity to activated protein C among postmenopausal women: a randomized trial.
Some
of the tests worth considering include those relating to insulin sensitivity such as the
oral glucose tolerance test, and a hormone panel that includes some or all
of the following: luteinizing hormone, follicle stimulating hormone, estradiol,
progesterone, androstenedione, 17 - hydroxy -
progesterone, insulin and testosterone.
A 10 - year French study
of HRT using a low - dose estradiol patch plus
oral progesterone shows no increased risk
of breast cancer, strokes or heart attacks.
These misconceptions are undoubtedly due to 1) the use
of the
oral (pill) form
of progesterone (e.g. Prometrium), and 2) the use
of blood tests to measure hormone levels.
Once you've had your final period and a year has passed (the official definition
of menopause), topical or
oral progesterone is the best choice.
MenoPower Plus Pack - One bottle
of Sprayology MenoPower
Oral Spray + one bottle
of Awakening Woman Restore Balance Natural
Progesterone Cream.
Although the combined treatment
of oral progestogens with percutaneous
progesterone significantly decreased the risk
of breast cancer (RR = 0.5; 95 % confidence interval 0.2 - 0.9) as compared with nonusers, there was no significant difference in the risk
of breast cancer in percutaneous
progesterone users versus nonusers among
oral progestogen users.
Premarin (the synthetic form
of estrogen, formulated from the urine
of pregnant horses) and Provera (the synthetic form
of progesterone, used for
oral contraception, which is counterintuitive as natural
progesterone is required for conception) are the most commonly used elements in hormone replacement therapy (HRT).
In the future
of medicine, I predict that
progesterone will replace progestins as
oral contraception.
Oral contraceptives are also popular because they disrupt ovulation and the production
of estrogen and
progesterone — the evil PMS hormones.
Given the first - pass liver loss with
oral progesterone preparations and the inconvenience
of injections and suppositories, a different route
of administration
of the natural
progesterone is highly desirable.
The caveat is that too high a dose
of progesterone cream, or
oral (pill)
progesterone, can create byproducts such as allopregnanolone.
A: Dr. Lee recommends the transdermal cream rather than
oral progesterone, because some 80 % to 90 %
of the
oral dose is lost through the liver.
The conclusion
of the authors: «These findings suggest that
oral micronized
progesterone has a more favorable effect on risk biomarkers for postmenopausal breast cancer than medroxyprogesterone acetate.»
Medications — hormone therapies and steroids,
oral contraceptives, and some other medications block production
of progesterone.
Sarkola et al. (1999) monitored
progesterone levels in response to acute alcohol intake (0.34 to 1.02 g / kg) in a group
of women comprising both
oral contraceptive users and non-users.
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