Sentences with phrase «of orexin»
The Clock mutants were also shown to exhibit reduced overall expression levels and a blunted diurnal rhythm of orexin mRNA, a hypothalamic neuropeptide involved in energy regulation (2).
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Without the activating effects of orexin, you start to feel sleepy, groggy, and less productive.
It's been shown that glucose can lower the activity of orexin, so consuming sugar before bed could help you sleep better.
«Deficient neuron - microglia signaling results in impaired functional brain connectivity and social behavior» Y. Zhan, R.C. Paolicelli, F. Sforazzini, L. Weinhard, G. Bolasco, F. Pagani, A. L. Vyssotski, A. Bifone, A. Gozzi, D. Ragozzino, C.T. Gross Nature Neuroscience 17 (3), 400-4006 (2014) «USPIO - loaded Red Blood Cells as a biomimetic MR contrast agent: a relaxometric study» A. Boni, D. Ceratti, A. Antonelli, C. Sfara, M. Magnani, E. Manuali, S. Salamida, A. Gozzi, and A. Bifone Contrast Media and Molecular Imaging 9, 229 - 236 (2014) «Distributed BOLD and CBV - weighted resting - state networks in the mouse brain» F. Sforazzini, A.J. Schwarz, A. Galbusera, A. Bifone, and A. Gozzi NeuroImage 87, 403 - 415 (2014) «Antimicrobial peptides design by evolutionary multiobject optimization» G. Maccari, M. Di Luca, R. Nifosì, F. Caldarelli, G. Signore, C. Boccardi, and A. Bifone PloS Computational Biology 9 (9): e1003212 (2013) «Differential effect of orexin - 1 and crf - 1 antagonism on stress circuits: a fMRI study in the rat with the pharmacological stressor yohimbine» A. Gozzi, S: Lepore, E: Merlo Pich, and A. Bifone Neuropsychopharmacology 38 (11): 2120 - 2130 (2013) «Water dispersal and functionalization of hydrophobic iron oxide nanoparticles with lipid - modified poly (amidoamine) dendrimers» A. Boni, L. Albertazzi, C. Innocenti, M. Gemmi, and A. Bifone.
Knockdown of orexin type 1 receptor in rat locus coeruleus increases REM sleep during the dark period.
Gozzi, A. *, Turrini, G., Piccoli, L., Massagrande, M., Amantini, D., Antolini, M., Martinelli, P., Cesari, N., Montanari, D., Tessari, M., Corsi, M., Bifone, A. Functional magnetic resonance imaging reveals different neural substrates for the effects of orexin - 1 and orexin - 2 receptor antagonists (2011) PLoS ONE, 6 (1), art.
Obesity causes leptin levels to be chronically high, making brain cells less sensitive to its actions, which contributes to the molecular switch that leads to the overproduction of orexin.
«Before, activating this receptor inhibited the secretion of orexin; now it promotes it.
Activating these CB1 receptors decreases inhibition of the orexin neurons, increasing orexin A release and food consumption.
The switch involves receptors that trigger or inhibit the release of the orexin A peptide, which stimulates the appetite, among other behaviors.
With additional controls, the Stanford group proved that the release of orexin from the lateral hypothalamus was what drove this behavior.
Not exact matches
Among the babies in the recent study, those who died of SIDS have significantly less orexin — approximately 20 % lower.
New sleep aids block the activity of brain peptides called orexins, which play a role in addiction
And it's particularly good news that orexins are found only in the lateral hypothalamus, says appetite researcher Jeffrey Friedman of Rockefeller University in New York City.
Furthermore, blue light via an optical fiber precisely and reliably generated waves of spikes in the orexin cells.
In obese mice, activation of this receptor stimulates orexin A release.
Using mice, this study found that in obesity, CB1 cannabinoid receptors become enriched on the nerve terminals that normally inhibit orexin neuron activity, and the orexin neurons produce more of the endocannabinoids to activate these receptors.
In normal - weight mice, activation of this receptor decreases orexin A release.
A new compound that inhibits the activity of alertness - promoting brain peptides called orexins shows promise as a sleeping pill, according to tests in people and animals.
Interestingly, sleep deprivation markedly increased the buildup of Aβ in the brain of a mouse model of AD; whereas a drug that block orexin actions markedly decreased the buildup of Aβ.
We will be assessing the effects of aging and orexin signaling on Aβ and other neural proteins both acutely and chronically.
Hypocretin (orexin) facilitates reward by attenuating the anti-reward effects of its co-transmitter dynorphin.
Sleep, aging, and Alzheimer's disease (AD): Regulation of AD - associated proteins by sleep, aging, and orexin
It's also been shown that levels of the hormones leptin, ghrelin, cortisol and orexin — all of which are involved in appetite or eating — are affected by lack of sleep.
The downside is this inflammatory response blocks the activity of the peptide mentioned earlier, orexin, the one that helps you stay awake and alert.
The homeostasis of body weight regulation and hunger signaling is composed of complex circuits of both central signals including orexin, neuropeptide Y, melanin concentrating hormone and alpha - melanocyte, and peripheral signals from the gut and adipose tissue, such as ghrelin, peptide YY and leptin (75).
For example, orexin / hypocretin levels increase during sleep loss (39) and orexin / hypocretin neurons are an important component of sleep — wakefulness and feeding neural systems (40, 41).
Norepinephrine and orexin (also called hypocretin) keep some parts of the brain active while we are awake.