Sentences with phrase «of osimertinib»

[33] It remains unclear how the BBB permeability of AZD3759 will compare with that of osimertinib.

Not exact matches

«Our hypothesis is that that's going to delay the emergence of resistance to osimertinib, because we're not maintaining that selection pressure,» says Solomon.

On the right, the presence within EGFR of a residue able to form additional interactions with osimertinib (as for the L718Q mutant form) prevents its reaction with Cys797 allowing EGFR to work and cancer cells to survive.

Sarah B. Goldberg, MD, MPH, an assistant professor of medicine at the Yale School of Medicine and Yale Cancer Center, discusses osimertinib (Tagrisso) for the treatment of patients with non — small cell lung cancer.

Osimertinib showed preclinical evidence of concentrations in mouse brain tissue 5 - to 25-fold higher than in plasma, [16] and has shown greater penetration of the BBB in mouse models than gefitinib, rociletinib, or afatinib.

One of these promising new compounds is osimertinib, a third - generation EGFR - mutant inhibitor that has been approved by the US Food and Drug Administration (FDA) for EGFR T790M — positive NSCLC.

[21] In the recently presented FLAURA study, in which osimertinib was used in untreated patients with advanced EGFR - mutant NSCLC, the HR for systemic disease control and CNS control similarly favored osimertinib over erlotinib or gefitinib, supporting the preclinical data that showed osimertinib's penetration across the BBB and providing support for using this agent in first - line management of EGFR - mutant patients with brain metastases.

The CNS overall response rate (ORR) was 70 % (21 of 30 patients) with osimertinib and 31 % with chemotherapy.

Approximately 50 % to 60 % of patients experiencing acquired resistance will have the T790M - resistance mutation, for which the third - generation EGFR TKI osimertinib is indicated.