Sentences with phrase «of osteoblast differentiation»

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Varghese and her team showed that they could control the differentiation of human pluripotent stem cells into functional osteoblasts — bone - building cells — simply by adding the molecule adenosine to their growth medium.

These products, including the major malarial by - product hemozoin, malarial proteins and as yet undefined virulence factors, induce MyD88 - dependent inflammatory responses in osteoclast and osteoblast precursors, leading to increased RANKL expression (a key molecule inducing osteoclast differentiation), and over-stimulation of osteoclastogenesis favoring bone resorption.»

«Our experiments showed that restoring H19 expression hindered by too much p53 restored «protective differentiation» of osteoblasts to counter events of tumor growth early on in bone cancer,» said co-author, Ihor Lemischka, PhD, Director of The Black Family Stem Cell Institute within the Icahn School of Medicine.

Both pathways appear to be responsible for the differentiation and proliferation of cell type similar to bone mass and osteoblasts (Fig. 6).

Spatial Segregation of BMP / Smad Signaling Affects Osteoblast Differentiation in C2C12 Cells.

We are using live imaging, transgenic reporters of osteoblast gene expression and targeted RNAseq approaches to identify the molecular regulators of progressive osteoblast differentiation during expansion of the skull.

'' «Figure 4: Effect of telomerase deficiency on extracellular matrix (ECM) protein molecules during in vitro osteoblast differentiation of BMSCs.

Through its various targets, MMP1 promotes not only tumor invasion but also breast cancer colonization to bone by mechanisms that include the release of membrane - bound EGF - like growth factors from tumor cells, leading to activation of EGF receptor signaling and suppression of OPG expression in osteoblasts, which in turn promotes the differentiation and activation of osteoclasts required for bone destruction and enhanced tumor growth in the bone microenvironment (32).

To evaluate whether ABL kinases might regulate the secretion of osteoblast - derived RANKL or OPG leading to osteoclast differentiation, we analyzed RANKL and OPG mRNA abundance in the murine osteoblast cell line 7F2 in response to conditioned medium from control and ABL1 / ABL2 knockdown breast cancer cells.

In vitro assays of the osteoblast cultures derived from the MT1 - / - and MT2 - / - mice showed a cell intrinsic defect in the proliferation, differentiation and mineralization abilities of MT2 - / - osteoblasts compared to WT counterparts and the mutant cells did not respond to melatonin addition.

Muthusami S, Senthilkumar K, Vignesh C, Ilangovan R, Stanley J, Selvamurugan N, Srinivasan N. «Effects of Cissus quadrangularis on the proliferation, differentiation and matrix mineralization of human osteoblast like SaOS - 2 cells.»