Sentences with phrase «of osteoblast gene»

We are using live imaging, transgenic reporters of osteoblast gene expression and targeted RNAseq approaches to identify the molecular regulators of progressive osteoblast differentiation during expansion of the skull.

Not exact matches

Downstream of the signaling system, Runx2 overexpression led to overexpression of bone - related genes, including genes expressed by osteoblasts, osteoclasts and osteocytes.

To find out how, he turned to an engineered strain of mice lacking a gene for what was then a mysterious protein called osteocalcin, which is produced by osteoblasts.

We show that expression of clock genes in osteoblasts is regulated by the sympathetic nervous system and leptin.

To investigate the underlying mechanisms, we undertook (1) bioinformatic, functional genomic annotation and human osteoblast expression studies; (2) gene - function prediction; (3) skeletal phenotyping of 120 knockout mice with deletions of genes adjacent to lead independent SNPs; and (4) analysis of gene expression in mouse osteoblasts, osteocytes and osteoclasts.

Studies showed that curcumin reduced joint swelling by modifying gene expression; inhibited inflammation by regulating NF - κB, a pro-inflammatory protein; and slowed down joint destruction by decreasing activity of osteoblasts, cells involved in bone breakdown.