In the bone metastatic microenvironment, the crosstalk between metastasized cancer cells and the surrounding bone cells is critical for the formation
of the osteoblastic or osteolytic phenotype.
«When implanted into the tibia or onto the skull of mice, moreover, we discovered that cells expressing miR - 940 can induce the kind
of osteoblastic lesions that are typical of prostate cancer.»
Not exact matches
The present study demonstrated that cancer - secreted microRNAs induced
osteoblastic bone metastasis through promoting the osteogenic differentiation
of bone - forming cells.
Tumor cells metastasized to bone modify the activity
of these cells and, depending on the type
of cancer, cause
osteoblastic or osteolytic changes.
The
osteoblastic differentiation
of these cells is manifested as «vascular calcification».