Sentences with phrase «of osteoblasts in»

Franziska Knopf (Weidinger, TUD)-- «Bone regenerates via dedifferentiation of osteoblasts in the zebrafish fin» (2011)

Both the number and activity of osteoblasts — cells that produce and reshape bone tissue — were increased within the bone marrow of mice with lung tumors compared with cancer - free animals; and reducing the number of osteoblasts in mice not only limited neutrophil infiltration of tumors but also interrupted tumor progression.

Not exact matches

The process takes place by means of a mechanism — unveiled in this study — that inhibits the activity of the osteoblasts, the cells that produce the bone matrix so that bones can grow during childhood and youth, and remain in good condition in adulthood.

Once there, the protein acts on the osteoblasts and inhibits Wnt activity, which is a cellular signalling pathway that is involved in the formation of the skeleton and in certain disorders, such as osteoporosis, arthritis and myeloma.

A new therapy changes the balance of osteoblasts (pictured here) and fat cells in the bone marrow, leading to stronger bones.

When transplanted into mice with bone defects, the osteoblasts formed new bone tissues in vivo without any signs of teratoma formation.

The stretched cells turned into bone - making cells called osteoblasts, Chen's team reports in the April issue of Developmental Cell.

In the next experiment, Karsenty looked for evidence of such signaling effects in osteoblasts from normal micIn the next experiment, Karsenty looked for evidence of such signaling effects in osteoblasts from normal micin osteoblasts from normal mice.

This demonstrates, Karsenty says, that the osteoblast component of the skeletal system has a direct role in regulating energy metabolism in ordinary animals.

This soluble factor was found at higher levels in the blood of animals with lung tumors, could increase the activation of osteoblasts and contributed to the maturation of neutrophils in cultured cells.

«Our findings indicate the existence of long - distance interactions between lung tumors and bones: lung tumors remotely activate osteoblasts, and those bone cells, in turn, shape immunity by supplying tumors with cancer - promoting neutrophils,» says Pittet, who is an associate professor of Radiology at Harvard Medical School.

Two nearly identical plots showing cell counts after exposure to osteoblasts (bone cells) lacking a particular protein appear in Figure 6c of the Blood paper.

Now, the Laboratory of Malaria Immunology Team at the Immunology Frontier Research Center (IFReC), Osaka University, headed by Professor Cevayir COBAN, have used mouse malaria models to show that robust immune activation and invasion of parasite by - products into the bone marrow during and after malaria infection leads to an adverse balance in bone homeostasis - a process usually tightly controlled - by bone forming osteoblasts and bone resorbing osteoclasts.

These products, including the major malarial by - product hemozoin, malarial proteins and as yet undefined virulence factors, induce MyD88 - dependent inflammatory responses in osteoclast and osteoblast precursors, leading to increased RANKL expression (a key molecule inducing osteoclast differentiation), and over-stimulation of osteoclastogenesis favoring bone resorption.»

Bone loss in models of leptin or leptin receptor deficiency has been linked with lower osteoblast activity (9, 14), suggesting that cellular leptin resistance in obesity might reduce bone formation.

«Our experiments showed that restoring H19 expression hindered by too much p53 restored «protective differentiation» of osteoblasts to counter events of tumor growth early on in bone cancer,» said co-author, Ihor Lemischka, PhD, Director of The Black Family Stem Cell Institute within the Icahn School of Medicine.

Our bones are in a constant state of flux as the number of bone - making (osteoblast) cells fluctuates, while the number of bone - degrading (osteoclast) cells also adjusts.

TRANCE is necessary and sufficient for osteoblast - mediated activation of bone resorption in osteoclasts.

Osteoblasts also migrate towards the top of the head in addition to undergoing oriented divisions.

Differential osteogenicity of multiple donor - derived human mesenchymal stem cells and osteoblasts in monolayer, scaffold - based 3D culture and in vivo.

Targeted disruption of nuclear factor erythroid - derived 2 - like 1 in osteoblasts reduces bone size and bone formation in mice.

Spatial Segregation of BMP / Smad Signaling Affects Osteoblast Differentiation in C2C12 Cells.

Similarity between the osteoblasts and the calicoblastic epithelium cells of scleractinian coral was also shown in the localization of the protein BMP in the tissue of S. pistillata (Zoccola et al., 2009), and for its role in the coral biomineralization (Mass et al., 2016; Zoccola et al., 2009).

We show that expression of clock genes in osteoblasts is regulated by the sympathetic nervous system and leptin.

'' «Figure 4: Effect of telomerase deficiency on extracellular matrix (ECM) protein molecules during in vitro osteoblast differentiation of BMSCs.

In addition to iPS cells derived from progeria - patients, the researchers successfully applied their method to adult mesenchymal stem cells, which can differentiate into a variety of cell types, including adipocytes, osteoblasts, chondrocytes, cardiomyocytes, and, as described lately, beta - pancreatic islets cells.

Through its various targets, MMP1 promotes not only tumor invasion but also breast cancer colonization to bone by mechanisms that include the release of membrane - bound EGF - like growth factors from tumor cells, leading to activation of EGF receptor signaling and suppression of OPG expression in osteoblasts, which in turn promotes the differentiation and activation of osteoclasts required for bone destruction and enhanced tumor growth in the bone microenvironment (32).

To evaluate whether ABL kinases might regulate the secretion of osteoblast - derived RANKL or OPG leading to osteoclast differentiation, we analyzed RANKL and OPG mRNA abundance in the murine osteoblast cell line 7F2 in response to conditioned medium from control and ABL1 / ABL2 knockdown breast cancer cells.

IL - 6 can induce osteoclast activation indirectly by altering the expression of RANKL and OPG in osteoblasts (51).

Depletion of ABL kinases in breast cancer cells decreased IL - 6 concentrations and was accompanied by increased OPG expression in osteoblasts.

To investigate the underlying mechanisms, we undertook (1) bioinformatic, functional genomic annotation and human osteoblast expression studies; (2) gene - function prediction; (3) skeletal phenotyping of 120 knockout mice with deletions of genes adjacent to lead independent SNPs; and (4) analysis of gene expression in mouse osteoblasts, osteocytes and osteoclasts.

In vitro assays of the osteoblast cultures derived from the MT1 - / - and MT2 - / - mice showed a cell intrinsic defect in the proliferation, differentiation and mineralization abilities of MT2 - / - osteoblasts compared to WT counterparts and the mutant cells did not respond to melatonin additioIn vitro assays of the osteoblast cultures derived from the MT1 - / - and MT2 - / - mice showed a cell intrinsic defect in the proliferation, differentiation and mineralization abilities of MT2 - / - osteoblasts compared to WT counterparts and the mutant cells did not respond to melatonin additioin the proliferation, differentiation and mineralization abilities of MT2 - / - osteoblasts compared to WT counterparts and the mutant cells did not respond to melatonin addition.

Magnesium is mitogenic (causes cell division) in osteoblasts (the major cellular component of bone) and magnesium depletion inhibits cellular growth.

Although adiponectin's signaling pathways are generally thought to be distinct from those of insulin, in this case it acts through the same signaling pathway as insulin in both osteoblasts and in the brain.

Research has shown that strontium may play a role in the formation of osteoblasts, new bone forming cells, while at the same time slowing the breakdown of old bone by inhibiting osteoclasts.

Over time heavy impact work increases the activity of osteoblasts within your body which in turn leads to bigger and stronger bones — now this might not be something you've considered but when you get to middle aged, or elderly, and you fall over you might find yourself thankful for your years of pumping iron as you will likely walk away far less injured then your more sedentary friends.

There is evidence of progesterone receptors in osteoblasts (bone building cells) but not for estrogen, indicating a bone - building role for progesterone.10

Collagen peptides are known to stimulate the growth of «osteoblasts,» which are the cells responsible for bone formation.14 Preliminary studies in rats also indicate that collagen supplementation may also help increase bone mineral density.15

The Opotowski team, which found that low vitamin A levels had as great an effect lowering BMD as did high vitamin A levels, suggested that vitamin A deficiency may contribute to increased fracture risk by allowing bone matrix to grow faster than it can be mineralized.12 Indeed, although the net effect of vitamin A is to stimulate osteoclasts and slow the growth of osteoblasts, vitamin A also causes osteoblasts to secrete a variety of enzymes and other proteins that are important to bone mineralization, including osteocalcin, which is a protein that plays a direct role in attracting and binding calcium within the bone matrix.6 By slowing the growth of the matrix but increasing the rate at which it is mineralized, adequate vitamin A helps to ensure sufficient bone density.

Studies showed that curcumin reduced joint swelling by modifying gene expression; inhibited inflammation by regulating NF - κB, a pro-inflammatory protein; and slowed down joint destruction by decreasing activity of osteoblasts, cells involved in bone breakdown.

Here's a quote: «Lactoferrin: Lactoferrin found in foods such as yogurt and kefir will stimulate new bone growth while preventing further breakdown of existing bone tissue, lactoferrin enhances both the growth and the activity of osteoblasts (the cells that build bone), and reduces the rate of bone cell death by 50 to 70 percent and decreases the development of osteoclasts, the cells responsible for breaking down bone.»

Finally, acute changes in blood calcium concentrations do not seem to elicit the secretion of the phosphaturic hormone fibroblast growth factor 23 (FGF - 23), which is produced by bone - forming cells (osteoblasts / osteocytes) in response to increases in phosphorus intake (see the article on Phosphorus)(2).

I think that probably the signs of pano or the actual development of enostosis, as some prefer to call it, in the hemophiliac dog come about via bleeding in the marrow with osteoblast (bone depositing cells) activity.

The results showed that the combination of avocado / soybean unsaponifiables (ASU), glucosamine hydrochloride, and chondroitin sulfate is effective in equine cartilage cells (chondrocytes) and bone cells (osteoblasts) at inhibiting expression and decreasing production of mediators involved in joint cartilage breakdown.