Mice that were deprived of either RbAp48 or osteocalcin exhibited poorer recall, and healthy levels
of osteocalcin correlated to better memory in both young and old animals.
In the present studies, the effects
of musculoskeletal loading on serum
osteocalcin in db / db mice were
correlated with improvements in glycemic control and insulin sensitivity, but it is important to note that total, rather than undercarboxylated,
osteocalcin was measured here.