Sentences with phrase «of osteoclasts»

Through its various targets, MMP1 promotes not only tumor invasion but also breast cancer colonization to bone by mechanisms that include the release of membrane - bound EGF - like growth factors from tumor cells, leading to activation of EGF receptor signaling and suppression of OPG expression in osteoblasts, which in turn promotes the differentiation and activation of osteoclasts required for bone destruction and enhanced tumor growth in the bone microenvironment (32).

To get slightly more scientific in terms of bone health, an acidic environment has been shown to encourage the activity of osteoclast cells.

«In fact, Del - 1 doesn't block the formation of osteoclasts, but it does put the brakes on the process,» Hajishengallis said.

Adding IL - 6 to the culture stimulated the production of osteoclasts.

Not only can IL - 17 encourage inflammation, but it can also encourage the development of osteoclasts, cells that break down bone, in this case teeth.

Interleukin (IL)-6 induction of osteoclast differentiation depends on IL - 6 receptors expressed on osteoblastic cells but not on osteoclast progenitors

In the bone, macrophages take the form of osteoclasts — the cells responsible for the resorptive processes associated with continuous bone remodeling.

«After six weeks, we saw reversals in inflammation, both clinically and by looking at cellular and molecular measures of osteoclast formation and inflammatory cytokines.»

A messenger protein called IL - 6 produced in bone marrow helps to encourage the growth of osteoclasts.

By adding vitamin D to a petri dish full of osteoclast precursors, they discovered that the hormone blocked a signal called RANK ligand that tells these cells to become osteoclasts.

Maria Aranzazu Sanchez Fernandez (Pompe, TUD)-- «Role of osteoclasts in bone formation and bone microenvironment» (2008)

We added the optimal dose of IL - 6 required to promote maturation of osteoclasts (Fig. 5I) to conditioned medium derived from ABL1 / ABL2 knockdown breast cancer cells.

Binding of RANKL to the RANK receptor on the surface of osteoclasts activates a pathway essential for osteoclast differentiation.

Both MMP1 and IL - 6 have been linked to the regulation of osteoclast activation (32, 33), and depletion of TNC decreases breast cancer metastasis (49).

This acute burst of osteoclasts causes substantial premature bone loss.

It works by inhibiting the work of osteoclasts.

With this new understanding of how Del - 1 can inhibit periodontal bone loss — both by reducing inflammation and by restraining the activity of osteoclasts that resorb bone tissue — the researchers tested it, in a preclinical model of periodontitis observing that Del - 1 significantly reduced inflammation and tissue damage and that there was significantly less bone loss.

The team evaluated the effects of recombinant irisin in bone cell lines, and found that irisin can directly increase the production of osteoblasts — cells that synthesize bone — and mineralization, while inhibiting the production of osteoclasts — cells that break down bone.

Bones One cup of boiled spinach provides over 1000 % of the RDA of vitamin K that can prevent excess activation of osteoclasts (the cells that break down bones), as well as promote the synthesis of osteocalcin, the protein that is essential for maintaining the strength and density of our bones.

Cnidiummonnieri to help boost libido and stop the formation of osteoclasts that can weaken bone

They also found the protein curbs the activity of osteoclasts, cells that absorb bone tissue, leading to a mechanistic explanation of how Del - 1 can prevent periodontal bone loss.

Co-author and principal investigator Akira Kudo, a professor in the Graduate School of Bioscience and Biotechnology at Tokyo Institute of Technology, said investigators found increased volume and activity of osteoclasts and significant reduction of bone mineral density in the fish aboard the station.

Besides, IL - 6 leads to the activation of osteoclasts and osteoporosis.

Not only does lactoferrin increase osteoblast activity, it also reduces the formation of osteoclasts, and these bone cells help to increase bone turn - over or bone loss.

Additionally, it was known to mediate the activity of osteoclasts (bone resorption cells), an important consideration in light of the risk of serious health consequences of osteoporosis.

Soy helps to decrease the activation of osteoclasts, the cells that resorb bone.

Estrogen suppresses the production of osteoclasts, the cells that break down the bone and slow the activity of existing osteoclasts.