Sentences with phrase «of other assays»

Not exact matches

No doubt there are many other new settings in which ministry is being assayed of which I am ignorant.

I assayed many ways to help to quiet my conscience, but it would not be; for the concupiscence and lust of my flesh did always return, so that I could not rest, but was continually vexed with these thoughts: This or that sin thou hast committed: thou art infected with envy, with impatiency, and such other sins: therefore thou art entered into this holy order in vain, and all thy good works are unprofitable.

The magnetic bead - based immunoassay panel facilitates detection of more samples than any other available assay, allowing researchers to get the greatest possible amount of data from each run.

The study concludes that the multiplex blood assay, if independently replicated and if integrated with studies of other classes of biomarkers, has the potential to be of high value in the clinical setting.

Enzyme assays showed that the mutations reduced HYAL2 protein levels in the tissues, which likely inhibited hyaluronan turnover, ultimately impacting development of the palate and other body parts.

A team of evolutionary biologists at Rice University, the University of Sheffield and eight other universities used a combination of ecological fieldwork and genomic assays to see how natural selection is playing out across the genome of a Southern California stick insect that is in the process of evolving into two unique species.

When the assay was run on patients infected with Zika virus and also on a control group of 540 patients infected by other flaviviruses or other viruses, plus healthy donors, the specificity was 95.9 percent.

The assay was implemented in five countries and tested using a large number of clinical samples from travelers and patients living in areas with a high level of exposure to Zika virus and other flaviviruses.

Vexing to doctors, the great majority of positive results are false, not because the tandem mass spec or the other assays have made errors but because certain babies are «borderline normal.»

«These results support that the antibody - based assay that we have developed is highly effective in detecting both recent and past Zika virus infections and in discriminating Zika from other flavivirus infections,» said Davide Corti, senior vice president and chief scientific officer of Humabs BioMed.

Dr Marcus Cooke, lead inventor of the new process, said: «Like many other labs, we use the Comet Assay routinely in our research, but we have always been frustrated by the current process, which is laborious and time consuming.

The Clariom brand of assays (Clariom D Pico and Clariom S Pico) include the most current content curated from the largest number of public - sequence databases, including RefSeq, NONCODE, Ensembl, Vega, lncRNAWiki, and RNAcentral, among several others.

Quirk in firefly - enzyme - based assay may throw into question the discovery of drugs for cystic fibrosis and other conditions

Professor Pallen explained the importance of the breakthrough, «Most other attempts to recover DNA sequences from historical or ancient samples have suffered from the risk of contamination, because they rely on amplification of DNA in the laboratory, plus they have required onerous optimisation of target - specific assays.

So if we assay a panel of tumors and see that half the tumors have a mutation in gene A, and the other half have a mutation in gene B, with no overlap, it's quite likely that the mutations play similar functional roles.

SGC0946 is a potent and selective inhibitor of Histone H3 - lysine79 (H3K79) methyltransferase DOT1L with an IC50 of 0.3 nM in a radioactive enzyme assay, and over 100-fold selectivity for DOT1L over other histone methyltransferases.

His other major discovery in antiviral research is the development of a novel microorganism based assay for antiviral drugs called «MOBA.»

One reaction serves as a positive control to amplify a portion of the tubulin gene found in all plants, and the other assays for genetic modification.

Testing for additional genes in the pathway and in a number of pathways is done through a number of commercial resources; the only other clinically relevant test is the homologous recombination defect assay, which is commercially available from Myriad Genetics.

He is currently working on the development of tools for malaria elimination, such as a serological assay to assess transmission among sentinel groups such as pregnant women, and the identification of hidden malaria infections in the bone marrow and other organs of the host.

The novel licensing agreement is focused on the discovery of pharmacological molecules offering a therapeutic solution and it is designed to streamline access to intellectual property associated with the SMN gene and thus speed the development of assays, models and other tools that are critical to the discovery process.

The specificity of the rRT - PCR assay allows its use for differential diagnosis of arboviral infections in Africa and Asia where ZIKV co-circulates with other arboviruses such as Dengue, Chikungunya and yellow fever viruses [22].

These findings will be discussed in the context of consistent data from other cognitive assays measuring deficits in response inhibition.

Research interests include analytical applications of bioluminescence and chemiluminescence, DNA probe assays, analytical microchips for genetic and other types of testing, analytical applications of nanotechnology, analytical interferences caused by heterophile antibodies and direct to consumer testing.

This assay is a useful tool for detection of ZIKV infection in regions where a number of other clinically indistinguishable arboviruses like dengue or chikungunya co-circulate.

This assay will be a useful tool for differential Zika fever diagnostics in a situation where number of other disease like malaria, dengue, chikungunya co-circulate and are clinically indistinguishable.

However, until an AMA1 malaria vaccine demonstrates clinical efficacy against genetically diverse natural parasites, the relevance of growth inhibition assays and other humoral and cellular immunogenicity endpoints for clinical development decisions will remain a matter of reasoned conjecture.

This workshop focuses on considerations for development of a multiplexed immunoassays; examples of multiplexed assays for research release and other toxicities associated with CAR - T cells; and a novel flexible platform for biomarker screening and assessment of toxicities in samples exposed to CAR - T cells.

The assay was shown to detect 37 ZIKV isolates covering a wide geographic in Africa and Asia over 36 years but none of the 31 other flaviviruses tested showing high analytical specificity.

Using standard enzyme - linked immunosorbent assays (ELISA) and peripheral blood mononuclear cell (PBMC) assays, researchers discovered that unlike previously described human antibodies to lipids, WR321 did not react with any of 17 other lipids it was tested against, including cholesterol, glycolipids, and other phospholipids such as cardiolipin and phosphatidylserine, but it bound specifically only to two phosphoinositides.

The specificity of each assay was determined using cDNA templates in duplicate from uninfected mouse tissues and other pathogens (Leptospira spp., Escherichia coli, Listeria monocytogenes, Staphylococcus aureus, Helicobacter spp.).

Four of the mAbs, 2T5C9, 2G9C, T1F11, and TB2H7, demonstrated diagnostic potential in enzyme - linked immunosorbent assays (ELISA) by their low to sub-nanomolar cross-reactivity with recombinant wild - type (WT) and mutant TTR aggregates and lack of binding to native TTR or amyloid fibrils formed by other peptides or proteins.

This allows for a one - step PCR reaction and pooling of amplicons from several different samples and targets (generated with other LymphoTrack Assays for the Illumina ® MiSeq ® instrument, sold separately), onto one MiSeq ® flow cell allowing for up to 24 samples per target to be analyzed in parallel in a single run.

To get new, additional insights on the features of kahweol as an anti-angiogenic compound, we carried out a complete set of in vitro assays previously used by us to characterize the anti-angiogenic effects of other compounds from natural sources, including aeroplysinin - 1, homocysteine, ursolic acid, puupehenone, hypericin, hyperforin and aloe - emodin, among others [11], [12], [13], [19], [20], [21].

In the CAM assay, the inhibitory doses exhibited by kahweol are similar to those of other anti-angiogenic compounds found by us to inhibit angiogenesis in the CAM assay [10], [19], and much lower than those of other anti-angiogenic compounds [21].

Further, to improve assay sensitivity, we used 1 ug of input DNA which is 4 - 5 times higher than that used by others [11 — 13, 16, 17], all while maintaining an assay sensitivity of 10 copies.

One current limitation of our study, and of others performing serologic and PCR testing for XMRV, is the absence of bona fide positive and negative control specimens from infected and uninfected humans to determine the analytical sensitivity and specificity of the detection assays.

The minimal inhibitory concentration for kahweol in this assay of «tubule - like» structures formation on Matrigel was 25 µM, in the range of concentrations at which other known antiangiogenic compounds produce this kind of effect [13], [27].

It is crucial to determine whether the toxins are active or inactive because molecular recognition assays (i.e., immunoassays) recognize surface features of proteins that may not be related to any enzymatic activity or other mechanism of toxicity.

To assess the sensitivity of other JAK1 mutation - positive cell lines to JAK inhibition, we performed a proliferation assay with increasing doses of INCB018424.

Sometimes this entails routine evaluation of gene expression in a tissue or organism, or other times high - throughput molecular assays involving thousands of samples.

In prior studies from other groups, approximately 50 % of mtDNA molecules have deletions as determined using an RT - PCR based assay.

EPA researchers have come a long way in the past few years, developing new assays to target various steps in the thyroid network, as well as other parts of the endocrine system.

Using recombinant proteins and a sensitive protein interaction assay, we establish the binding interdependencies of all the other known RH5 complex components and conclude that the RH5Nt - P113 interaction provides a releasable mechanism for anchoring RH5 to the merozoite surface.

The table also details whether individual assays provide information directly on SMN levels or functions, on other metrics that are downstream of SMN activity, or on both direct and downstream SMN readouts.

Through the CIC program, the Cancer Research Institute conducts a number of important initiatives that seek among other things to build consensus across the field on key issues, to develop and implement new standards for carrying out and reporting immunological monitoring assays of therapeutic cancer vaccines, and to establish and promote the adoption of new criteria for evaluating the clinical impact of cancer immunotherapies.

With ~ 81 % of the human proteome on a single slide, ImmuneProfiler represents a more comprehensive and high - throughput alternative to other assay platforms for the development of predictive early diagnostic tests.

Other studies included use of rapid tests for HIV, HBV and HCV for emergency field testing of the «Walking Blood Bank» in military operations; use of dried blood spots for collection of specimens in the field for testing of HIV, Dengue, West Nile Virus and Chikungunya Virus; and molecular assays for monitoring Chlamydia trachomatis, Neisseria gonorrhoeae, Ebola virus, and other infectious agents in epidemiology and vaccine research stuOther studies included use of rapid tests for HIV, HBV and HCV for emergency field testing of the «Walking Blood Bank» in military operations; use of dried blood spots for collection of specimens in the field for testing of HIV, Dengue, West Nile Virus and Chikungunya Virus; and molecular assays for monitoring Chlamydia trachomatis, Neisseria gonorrhoeae, Ebola virus, and other infectious agents in epidemiology and vaccine research stuother infectious agents in epidemiology and vaccine research studies.

In the future, this conserved region may also be used as a target for the development of a pan-rhabdovirus RT - PCR assay or for other members of the order Mononegavirales as this region appears to be conserved within several virus families.

It is tantalizing to speculate that amiodarone HCl might also be toxic to other stem cell populations that demonstrate increased ion channel expression relative to their differentiated derivatives, including mesenchymal stem cells (MSCs) and endothelial precursor cells [36], thus expanding the utility of the automated screening assay described here.