Sentences with phrase «of other biomarkers»
They're seeing all sorts of other biomarkers that are indicative that we're shifting people into the parasympathetic state, and to me that's like the biggest top of the food chain issue is whether you're in the parasympathetic or whether in the sympathetic, and for me modern life it is very tough to stay having a balance between those two.
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«Our study linked a positive score in this test with quicker spread to the brain, and importantly showed the factor we were measuring is providing information on patient outcome independently of other biomarkers already measured in the clinic.
Not exact matches
«For the first time, scientists have attempted to account for numbers of people with biomarkers or other evidence of possible preclinical Alzheimer's disease, but who do not have impairment or Alzheimer's dementia.
Intake of rice early in childhood has not been well characterized in the United States, and there are only limited data from other regions of the world.5, 6 Moreover, biomarker concentrations of As among infants consuming rice are virtually unknown.
The focus of those hopes is the liquid biopsy: a test that could detect and analyze a solid tumor from biomarkers in the bloodstream or other easily sampled body fluids, such as saliva.
«It can handle multiple biomarker technologies simultaneously, such as complex flow cytometry, next - generation sequencing, immunosequencing, epigenetic profiling, and other types of asssys measuring biological variation as well,» says Marshall.
Unfortunately, the high background of normal proteins, along with the presence of circulating phosphatases and other degradation enzymes, consistently stump researchers searching for these rare tumor biomarkers.
This suggests that these small molecules, and possibly others, might be clinically relevant biomarkers of mTBI.
Sahakian agrees that other subtypes of depression are likely to be identified with different biomarkers.
In addition to suggesting that creatine could slow the progression of HD, these results also imply that neuroimaging may provide a useful biomarker of disease modification in studies of other potential treatments.
In a report published June 28 in the Journal of General Internal Medicine, the research team describes how these interventions reduced overuse of troponin and other biomarker testing without compromising patient care.
Biomarkers are proteins or other molecules that can help diagnose or track progression of disease; one example is prostate - specific antigen, the biomarker used to detect prostate cancer.
Mochly - Rosen and colleagues identified several other potential biomarkers that were elevated in HD model mice, including the levels of 8 - hydroxy - deoxy - guanosine, a product of oxidative DNA damage, in the urine and the presence of mutant huntingtin aggregates and oxidative damage in muscle and skin cells.
«Adding these two biomarkers provided statistically significant improvement for all early stage cancer versus healthy controls as well as other subcohorts when used with the current gold standard biomarker, CA 19 - 9,» said Ann Killary, Ph.D., professor of Translational Molecular Pathology.
«This finding,» Villanueva said «opens the door to developing new biomarkers and new therapeutic strategies exploiting these characteristics of exosomes in breast tumors, and other tumors such as ovarian and endometrial cancer among others.»
But because the new DNA objects are on the same size scale of devices that can be patterned using computer chip lithography, it might be possible to integrate the two technologies and design DNA origami to detect cancer biomarkers and other biological targets that could then be read out by electronic devices, Castro says.
Reports of unvalidated biomarkers will only be considered in the context of a clear experimental, mechanistic connection to disease or other unique contribution to understanding of disease or clinical practice.
The study concludes that the multiplex blood assay, if independently replicated and if integrated with studies of other classes of biomarkers, has the potential to be of high value in the clinical setting.
«The Quanterix Simoa will accelerate the discovery of new biomarkers to identify TBI and the development of new treatments, including targeted medications and other therapies,» says Charles L. Marmar, MD, the Lucius Littauer professor and chairman of Psychiatry at NYU Langone and executive director of the Cohen Veterans Center.
These in turn depend on development of brain imaging tests or biomarkers that could be measured in the blood or other body fluids to allow a diagnosis of the disease in living people.
Two other big initiatives fared better: a proteomics effort to identify proteins in blood and other biomarkers that might work as early warning signs of cancer, and the most recent: a human Cancer Genome Atlas.
The study found no clear change in blood eosinophils with dupilumab therapy; however, other biomarkers decreased, including fractional exhaled nitric oxide, thymus and activation regulated chemokine, immunoglobulin E and eotaxin - 3, confirming the biologic activity of dupilumab.
His troubles also led to an Institute of Medicine report that faulted Duke's oversight and found broad problems in the cancer field with using gene signatures and other biomarkers to guide treatment.
They are investigating indoor emissions in other areas of Tibet and plan to link these measurements to a biomarker study based on blood samples of people living in the households.
But cardiologist Nilesh Samani of the University of Leicester in the U.K. says that the Danish group took «a fine approach» that can be applied to other biomarkers, especially before hundreds of millions of dollars are spent to develop drugs that target a molecule that may not in fact be causing a disease.
Still, the work of Hahn and colleagues, along with other recent papers, illustrates how the hunt for a concrete biological signature of autism, a biomarker, is gaining speed.
Hariri said he hopes that other researchers looking for biomarkers of mental illness will begin to consider methylation above and beyond DNA sequence - based variation and across different tissues.
Each type of cancer produces a unique set of metabolites and other biomarkers that act as fingerprints.
In the group that cycled indoors, the researchers compared the new device's biomarker readouts to conventional laboratory analysis of the same sweat and found the two sets of results agreed with each other.
The device measures sweat and sweat biomarkers accurately and in real time, allowing athletes, military personnel, fitness pros and others to monitor sweat rate and electrolyte loss, so they can keep hydrated, replenish their electrolytes and stay on top of their game.
Serum phosphorus was a significant predictor of progression to the study end point of dialysis initiation (HR 1.44, 95 % CI 10.7 - 1.93), even after controlling for age, sex, race, smoking status, diabetic status, BMI, and other biomarkers.
The team's next avenue of research will be focused on identifying a «biomarker» that can identify this distinct suppressive cell elsewhere in the body — for example, in blood or other samples — as a potential predictive clinical tool to determine when these cells are present in patients, which currently can not be done.
In previous studies, the same group along with others had demonstrated that microRNAs (miRNAs) produced by eukaryotic cells and viruses are present in human blood in highly stable, cell - free forms and these so called circulating miRNAs can serve as non-invasive biomarkers for the early diagnosis of various diseases, including viral diseases.
Dr. Quintana's research is focused on the regulation of the adaptive and innate immune response and the identification of biomarkers for multiple sclerosis (MS) and other immune - mediated diseases.
First author Michele T. Yip - Schneider, Ph.D., associate research professor of surgery, and senior author C. Max Schmidt, M.D., Ph.D., MBA, professor of surgery, biochemistry and molecular biology, report this is the first cyst fluid protein biomarker that can differentiate serous cystic neoplasms, a benign type of cystic lesion, from all other cancerous or precancerous cystic lesions without surgery.
The researchers also are seeking other potential drug targets in the 50 percent of patients who don't have high levels of the anti-death protein, as well as biomarkers in addition to CA125 that could be used to screen for ovarian cancer.
«Identifying specific signatures of ribonucleotide incorporation in DNA may represent novel biomarkers for human diseases such as cancer, and other degenerative disorders.»
«Our smart contact lens provides a platform for wireless, continuous, and noninvasive monitoring of physiological conditions, as well as the detection of biomarkers associated with ocular and other diseases,» says Professor Park.
Lee says the research team will measure the amount of methylation in patients» cells when they begin their treatment and the presence of genes associated with irinotecan resistance, among other possible biomarkers.
The study will involve doing an analysis not only of benzene biomarkers and other volatile organic compounds, but also of certain heavy metals in urine and hair samples.
«GECCO aims to continue to discover additional colorectal cancer - related variants by investigating how genetic variants are modified by other environmental and lifestyle risk factors, including biomarkers as well as how they influence patient treatment response and survival,» Peters said, emphasizing how much further research is required to uncover the specific mechanisms by which genes modulate the intake of certain foods on colorectal cancer risk.
Researchers presenting their work at the American Orthopaedic Society for Sports Medicine's (AOSSM) Specialty Day in San Diego are highlighting how a set of biomarkers on the day of surgery may explain why some individuals have worse PTOA than others after two years.
The researchers» next steps will involve expansion of the biomarkers identified in this study to other cancer types, especially breast cancer, due to the hormonal input that is a common factor in gynecologic tumors.
Other biomarkers and genetic signatures are being used in an effort to predict the aggressiveness of an individual patient's prostate cancer, «but the current information doesn't make it possible for their gene signature to be an actual target for precision medicine targeted therapy,» Ellis explained.
Confirmation of the biomarkers in other cancer types will facilitate further characterization and validation to provide mechanistic understanding of how and why these specific gene - targets become modulated to accentuate or inhibit tumor metastasis.
During the study, 24 people travelled to Mount Everest and underwent assessments of glucose control, body weight changes and inflammation biomarkers at Everest Base Camp, which is at an altitude of 5,300 m. Half the group remained at Base Camp while the other half climbed the mountain to a maximum of 8,848 m. Measurements were taken in each group at week six and week eight of the trek.
The biomarkers also point to other underlying mechanisms that contribute to the progression of CF and could lead to better therapeutic interventions earlier in life.
«Future research will focus on optimizing the candidate therapies discovered by our team in this study as well as developing biomarkers that can be used to test the efficacy of other potentially promising drugs,» says Dr. Rothstein
Other areas of medicine have used this approach to define disease processes using biomarkers, for example: bone mineral density, hypertension, hyperlipidemia and diabetes are defined by biomarkers.
Compared to the people with no elevated levels, people with elevated levels on three or more biomarkers had on average 5 percent lower volume in the hippocampus and other areas of the brain associated with Alzheimer's disease.