Phagocytes — of which the macrophage is the prototypical cell but which also include a
variety of other cell types such as microglia, dendritic cells, fibroblasts, and osteoclasts — play a broad role in host homeostasis in addition to host defense.
To create different cell types in the lab, stem cells must be coaxed down the road of determination — the branching paths that fetal cells normally travel to become neurons, skin cells, muscle cells, or any
number of other cell types.
Even though the transplanted cells never integrated with the host, mice that received this transplant showed better recovery, including less necrosis and fibrosis, compared with mice that received
transplants of other cell types.
A team led by Mónica Bettencourt - Dias at the Instituto Gulbenkian de Ciência (IGC; Portugal) have cracked this mystery, shedding light upon a critical mechanism whose deregulation leads to infertility, and that is important for the
working of other cell types.
Data from the laboratory shows that signals from these molecules through their receptors control the activities and long - term survival of T cells, as well as affecting the
activities of other cell types including dendritic cells, macrophages, and epithelial cells.
We found that it is very selective and potent at stopping the growth of blood vessel cells without having negative effects on the
growth of other cell types from the eye and elsewhere in the body.
In a recent article we discussed the amazing process known as «fetal microchimerism» by which the fetus contributes stem cells to the mother which are capable of regenerating her damaged heart cells, and possibly a wide
range of other cell types.
Dr. Ding's work revolves around chemical reprogramming — the use of small molecule drug mixtures to coax fibroblasts into becoming a
variety of other cell types.