Sentences with phrase «of other genes affected»

Not exact matches

Before this can happen though, Teixeira said that his team will first have to determine whether the Stk11 gene or the other genes and proteins it controls are similarly affected in the human form of BPH.

The handful of cases that still occur are most likely to affect non-Jews, families carrying mutations other than the distinctly Ashkenazi variants of the Tay - Sachs gene.

Unlike other autoimmune disorders with associated risk factors, APECED is clearly caused by a mutation in a single gene, based on analyses of affected families.

Other directions for future research, Liu said, include looking at the role of CLOCK in more forms of the disease, learning more about exactly how CLOCK affects neural circuits to disrupt adequate inhibition of excitatory neurons, and examining whether any of the genes that CLOCK regulates are especially important in the disorder.

But many of the genes that affect lifespan in worms affect lifespan in other organisms.

Affected family members, the group found, had inherited one or two defective copies of ZIC3, a previously unknown gene that appears to code for a transcription factor — a protein that switches other genes on or off.

Hockemeyer says that it's unlikely to be another mutation, but rather an epigenetic change that affects expression of the telomerase gene, or a change in the expression of a transcription factor or other regulatory proteins that binds to the promoter upstream of the telomerase gene.

Transcription - factor genes code for proteins that regulate the activity of other genes and so affect an animal's ability to respond to its environment.

They looked at other genes that interacted with TAK1 kinase including activators and inhibitors of the TAK1 pathway and found that most of them also affected regeneration, but only when worms were infected.

George Bray, who heads the clinical obesity and metabolism department at Louisiana State University, says environment and behavior — like lack of access to exercise facilities and overeating — so strongly affect gene activity that you can not focus on one while ignoring the other.

The genes that affect hair colour also affect other cancer types, while other pigment genes affect the chances of having Crohn's and other forms of bowel disease.

To figure out how corn and weeds affect each other's gene response, Clay and a team of two research associates and a soils expert, planted plots of velvetleaf alone, corn with velvetleaf and corn kept weed - free.

The research suggests that reducing production of the protein, called myoferlin, affects cancer cells in two primary ways: by changing the activation of many genes involved in metastasis in favor of normal cell behavior, and by altering mechanical properties of cancer cells — including their shape and ability to invade — so they are more likely to remain nested together rather than breaking away to travel to other tissues.

White and her colleagues set out to identify how FoxP2 affects thousands of other genes in zebra finches before and after the critical period for learning closes.

Over the past decade Hariri has looked for evidence of how other genes affect other aspects of our minds, including self - control and memory.

«Patients» individual genomes may affect efficacy, safety of gene editing: CRISPR - Cas9 and other gene editing systems may need to be customized to the patient.»

A new study of more than 6000 pairs of twins finds that academic achievement is influenced by genes affecting motivation, personality, confidence, and dozens of other traits, in addition to those that shape intelligence.

Research from other scientists at Johns Hopkins, he says, had suggested that some tumors, particularly those that affect the nervous system, have mutations in the ATRX gene, which produces proteins that appear to maintain the length of telomeres, repetitive segments of DNA on the ends of chromosomes that typically shorten each time a cell divides.

In fish larvae without the EGFL7 gene, however, other genes compensate for the loss, so that the inhibitor hardly affects the growth of blood vessels (below).

The gene affects credit - card debt the way other genes have been found to play a role in breast cancer: a particular version of the gene increases risk, but many other genetic and environmental factors are important, too.

One of the «hits» was Lhx1, a member of a family of genes whose protein products affect development by controlling the activity of other genes.

Sometimes cells make the correct amount anyway; other times CNVs affect DNA regions that regulate the expression of still other genes, making the problem more complicated.

DNA methylation and other epigenetic alterations — chemical changes to DNA that can alter a gene's expression without affecting its protein - coding sequence — may underlie some of the lasting biochemical havoc, Ghanei says.

Also, unlike chemical manipulators that diffuse throughout a cell, light can be applied to specific genes without affecting other parts of the cell.

The researchers plan to investigate what percentage of individuals individuals with intellectual disability and autism may carry CC2D1A mutations and to determine whether other genes affect neurons in a similar fashion.

«We are hopeful that a systemic dose and delivery of gene therapy would broadly affect whole - body strength and function, and we are working on a host of projects for such systemic delivery in Pompe and other neuromuscular conditions,» said Barry Byrne, M.D., Ph.D., director of the Powell Gene Therapy Center, a professor of pediatrics in the UF College of Medicine, and a member of the UF Genetics Institgene therapy would broadly affect whole - body strength and function, and we are working on a host of projects for such systemic delivery in Pompe and other neuromuscular conditions,» said Barry Byrne, M.D., Ph.D., director of the Powell Gene Therapy Center, a professor of pediatrics in the UF College of Medicine, and a member of the UF Genetics InstitGene Therapy Center, a professor of pediatrics in the UF College of Medicine, and a member of the UF Genetics Institute.

«A couple of other genes are also evolving rapidly and we know nothing about them,» he says, adding that they may affect the behavior of hemagglutinin.

The gene in question is for a chemical transporter that fine - tunes transmission of serotonin, the neurotransmitter affected by the antidepressant Prozac and others of its ilk.

«This tells us that the NuRD complex is very influential — not only does it affect the activity of genes directly, it also controls other regulators of multiple genes,» Bonni said.

One of them had a deletion on chromosome 22 that affected, among other genes, SHANK3, which has been implicated in mental retardation.

A new study finds that academic achievement is influenced by genes affecting motivation, personality, confidence, and dozens of other traits, in addition to those that shape intelligence.

CSIC researcher adds: «We have confirmed that mutation is found in both copies of the gene, one inherited from the father and the other one inherited from the mother, in the four women affected by the disease, causing an absolute absence of STAG3 protein and meiotic cohesin complex in these women.

The regulation of the CAMP gene by vitamin D was discovered by Gombart, and researchers are still learning more about how it and other compounds affect immune function.

On the other hand, the gene Trypsin - 7 appears to affect the recognition potential, thus enabling — at least in part — the identification of the host colonies required for a raid,» adds Feldmeyer in summary.

The Arizona researchers studied whether cage conditions affect mice with one copy of a gene called fibulin - 4, a member of a family of genes believed to code for proteins that stabilize the connective tissue found between cells in arteries and other blood vessels.

Normally, FOXP2 coordinates the expression of other genes, but in affected members of the KE family, it was broken.

There are some data on how groups of genes are impacted by one chemical, and other genes are affected by different chemicals.

Clock genes are extremely influential, affecting the activity of most other genes in the body in one way or another.

Other medical sequencing projects will use DNA sequencing to: discover new genes that are involved in common diseases; identify the genes responsible for dozens of relatively rare, single - gene (autosomal Mendelian) diseases; sequence all of the genes on the X chromosome from affected individuals to identify those involved in sex - linked diseases; and survey the range of variants in genes known to contribute to certain common diseases.

Although TMAdV was found to be highly divergent from other adenoviruses, different isolates of TMAdV from 3 affected titi monkeys were remarkably conserved, sharing 100 % identity across the full - length hexon gene (data not shown).

The current work shows that changes in the genetic code of a particular gene can control epigenetic marks at different genes, implying that a gene's genetic code can affect whether other genes are turned on and off, which makes it important to understand the function of all genes involved, not just the one with the so - called misspelling.

Compared with the ancestral lineage, the East African cichlid genomes possess: an excess of gene duplications; alterations in regulatory, non-protein-coding elements in the genome; accelerated evolution of protein - coding elements, especially in genes for pigmentation; and other distinct features that affect gene expression, such as insertions of transposable elements and regulation by novel microRNAs.

In the associated paper, Vitkup, Iossifov and others use a novel form of analysis called NETBAG (network - based analysis of genetic associations) to identify «the large biological network of genes affected by rare de novo CNVs in autism.»

Since then, however, other researchers have observed the same gene fusion in a percentage of lung, esophageal, breast, head and neck, cervical, and bladder cancers, affecting tens of thousands of cancer patients overall.

July 13, 2016 New technique targets gene that causes neurodegenerative disease Neuroscientists at the University of Chicago studying a unique gene that expresses two proteins, one that is necessary for life and another, that when mutated causes a neurodegenerative disease called spinocerebellar ataxia type 6 (SCA6), have developed a technique to selectively block the disease - causing protein without affecting the other.

These results imply that mutations in the gene encoding RyR1 will not only affect skeletal muscles, but other tissues that express this calcium channel as well, thereby broadening the clinical spectrum of disorders due to RyR1 dysfunctions.

They also chose a gene target that might itself be problematic, given that it is part of a closely linked family of globin genes with highly related sequences, making it hard to target one without affecting the others.

Targeted gene therapy, which would affect smooth muscle cells but not skeletal muscle, holds promise for treatment of these and other disorders.

That is, the arrival of toads removes some genetic traits from the predator population (genes that make predators vulnerable to toads) but other traits (e.g., genes that tell the predator not to eat toads) are not affected.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.