The first thing you notice about Diane Simeone, M.D., the Lazar J. Greenfield Professor of Surgery and director
of the Pancreatic Cancer Research Center, is her tireless passion for finding better ways to detect and treat pancreatic cancer.
Editor's note: This is part of a series of blogs that focus on members
of the Pancreatic Cancer Research Center.
The Lustgarten Foundation, the nation's largest private funder
of pancreatic cancer research, established the new Distinguished Scholars initiative to identify and fund the best minds in research today to engage in pancreatic cancer research.
The Lustgarten Foundation is America's largest private funder
of pancreatic cancer research.
«This is a watershed moment in the field
of pancreatic cancer research,» said Dr. Sharp.
Maggie Blanks, CEO
of the Pancreatic Cancer Research Fund, said: «Professor Magee's findings add further weight to a growing body of evidence which points to Hedgehog signalling as an important driver of pancreatic cancer.
Not exact matches
Helmy Eltoukhy, Co-founder and CEO, Guardant Health Dr. Sam Hanash, Director, Red and Charline McCombs Institute for the Early Detection and Treatment
of Cancer, MD Anderson
Cancer Center Dr. Anirban Maitra, Scientific Director, Sheikh Ahmed Center for
Pancreatic Cancer Research, MD Anderson
Cancer Center Moderator: Clifton Leaf, Fortune
Mogroside V has been found in
research to have the ability to inhibit tumor growth in
pancreatic cancer by interfering with the rapid dividing
of cancer cells, preventing angiogenesis (blood flow to the tumor), and even promoting
cancer cell death (10).
The senior, majoring in biology, who is
researching the potential
of using the spice turmeric to combat
pancreatic cancer, said it was «inspiring» that Biden was pushing for more
cancer research.
«This
research represents a big step forward in understanding why some tumors are more aggressive than others and being able to predict rationally which neoantigens will be the most effective at stimulating an immune response,» said Dr. Balachandran, a member of the David M. Rubenstein Center for Pancreatic Cancer Research at MSK, and corresponding author of the companion study in
research represents a big step forward in understanding why some tumors are more aggressive than others and being able to predict rationally which neoantigens will be the most effective at stimulating an immune response,» said Dr. Balachandran, a member
of the David M. Rubenstein Center for
Pancreatic Cancer Research at MSK, and corresponding author of the companion study in
Research at MSK, and corresponding author
of the companion study in Nature.
Tal Danino, a professor at the Data Science Institute, is conducting
research that could help scientists combat the most lethal
of cancers:
pancreatic cancer.
Professor Paolo Boffetta (MD), the Annals
of Oncology associate editor for epidemiology and Director
of the Institute
of Translational Epidemiology at the Icahn School
of Medicine at Mount Sinai in New York (USA), commented: «These results are extremely important in showing that reducing
cancer mortality can be achieved: priority should be given to
research in
cancers with unfavourable trends, such as
pancreatic cancer, and in reducing
cancer mortality disparities, both between countries (Central / Eastern versus Western Europe), and within countries, for example, between socioeconomic groups.
Adding two blood - borne proteins associated with
cancer cell migration increases the predictive ability of the current biomarker for pancreatic cancer to detect early stage disease, a research team from The University of Texas MD Anderson Cancer Center reports in the Journal of the National Cancer Inst
cancer cell migration increases the predictive ability
of the current biomarker for
pancreatic cancer to detect early stage disease, a research team from The University of Texas MD Anderson Cancer Center reports in the Journal of the National Cancer Inst
cancer to detect early stage disease, a
research team from The University
of Texas MD Anderson
Cancer Center reports in the Journal of the National Cancer Inst
Cancer Center reports in the Journal
of the National
Cancer Inst
Cancer Institute.
The panel will next be validated in a set
of samples from
pancreatic cancer patients who provided a
research blood sample prior to their diagnosis.
The development
of new treatments for
pancreatic cancer is set to be transformed by a network of clinical trials, aiming to find the right trial for the right patient, after a # 10 million investment from Cancer Resear
cancer is set to be transformed by a network
of clinical trials, aiming to find the right trial for the right patient, after a # 10 million investment from
Cancer Resear
Cancer Research UK.
Professor Andrew Biankin, a
Cancer Research UK pancreatic cancer expert at the University of Glasgow, said: «PRECISION Panc aims to transform how we treat pancreatic cancer by matching the right treatment to the right pa
Cancer Research UK
pancreatic cancer expert at the University of Glasgow, said: «PRECISION Panc aims to transform how we treat pancreatic cancer by matching the right treatment to the right pa
cancer expert at the University
of Glasgow, said: «PRECISION Panc aims to transform how we treat
pancreatic cancer by matching the right treatment to the right pa
cancer by matching the right treatment to the right patient.
A newly identified biomarker panel could pave the way to earlier detection and better treatment for
pancreatic cancer, according to new
research from the Perelman School
of Medicine at University
of Pennsylvania.
«If we can define the boundaries
of molecular targets in saliva, then we can ask what the constituents in saliva are that can mark someone who has pre-diabetes or the early stages
of oral
cancer or
pancreatic cancer — and we can utilize this knowledge for personalized medicine,» said Dr. David Wong, a senior author
of the
research and UCLA's Felix and Mildred Yip Endowed Professor in Dentistry.
The current standard
of care for advanced
pancreatic cancer — a combination
of nab - paclitaxel and gemcitabine — was developed by TGen and the HonorHealth
Research Institute, and approved by the U.S. Food and Drug Administration in 2013.
The
research groups then examined the landscape
of the
pancreatic cancer epigenome using a combination
of stains on patient tissues, direct examination
of the proteins that wrap DNA and whole - genome sequencing
of the detected epigenetic changes to map precisely where they were located.
«
Pancreatic cancer cells are deadly because they program nearby immune cells to permit the tumors to survive and grow,» says study author George Miller, MD, head of the Cancer Immunology Program at Perlmutter and vice chair for research in the Department of Surgery at NYU La
cancer cells are deadly because they program nearby immune cells to permit the tumors to survive and grow,» says study author George Miller, MD, head
of the
Cancer Immunology Program at Perlmutter and vice chair for research in the Department of Surgery at NYU La
Cancer Immunology Program at Perlmutter and vice chair for
research in the Department
of Surgery at NYU Langone.
Maggie Blanks,
Pancreatic Cancer Research Fund's CEO, said: «It's because of these bleak facts that our funding strategy focuses on finding and developing alternative, effective treatments for patients as well as finding a way to diagnose pancreatic cancer at an ea
Pancreatic Cancer Research Fund's CEO, said: «It's because of these bleak facts that our funding strategy focuses on finding and developing alternative, effective treatments for patients as well as finding a way to diagnose pancreatic cancer at an early
Cancer Research Fund's CEO, said: «It's because
of these bleak facts that our funding strategy focuses on finding and developing alternative, effective treatments for patients as well as finding a way to diagnose
pancreatic cancer at an ea
pancreatic cancer at an early
cancer at an early stage.
The work, funded by national charity
Pancreatic Cancer Research Fund, uncovers new evidence that PAK4 plays a key role in enabling cancer cells to grow and to spread from the pancreas into other areas of the body, a process called metas
Cancer Research Fund, uncovers new evidence that PAK4 plays a key role in enabling
cancer cells to grow and to spread from the pancreas into other areas of the body, a process called metas
cancer cells to grow and to spread from the pancreas into other areas
of the body, a process called metastasis.
«As someone who
researches pancreatic cancer, I think this discovery is significant because it defines mechanisms that lead to this cancer in ways that we didn't know about before,» says Firpo, who's also a member of the Pancreas Cancer Research Program and Experimental Therapeutics Program at the University of Utah's Huntsman Cancer Inst
cancer, I think this discovery is significant because it defines mechanisms that lead to this
cancer in ways that we didn't know about before,» says Firpo, who's also a member of the Pancreas Cancer Research Program and Experimental Therapeutics Program at the University of Utah's Huntsman Cancer Inst
cancer in ways that we didn't know about before,» says Firpo, who's also a member
of the Pancreas
Cancer Research Program and Experimental Therapeutics Program at the University of Utah's Huntsman Cancer Inst
Cancer Research Program and Experimental Therapeutics Program at the University
of Utah's Huntsman
Cancer Inst
Cancer Institute.
«This study not only represents a longstanding collaboration between the University
of Utah and UCSF but also is a reflection
of the transition in
research from single investigators working on their own to highly collaborative studies with experts in many fields from different institutions,» says Mulvihill, who is also a
pancreatic cancer surgeon and an investigator with the University of Utah's Huntsman Cancer Inst
cancer surgeon and an investigator with the University
of Utah's Huntsman
Cancer Inst
Cancer Institute.
Because
of these limitations, most
pancreatic cancer research relies on genetically engineered mouse models
of the disease, which can take up to one year to generate.
When Andrew Biankin walked into the Garvan Institute
of Medical
Research in Sydney, Australia, in 1998 and said he wanted to study
pancreatic cancer, the head
of the department was unimpressed.
The
research team combined activated platelets primed for the clotting process with three groups
of cancer cells: • metastatic colon
cancer (cells that have spread outside the colon), • nonmetastatic colon
cancer (cells that grow only within the colon) and • nonmetastatic
pancreatic cancer cells.
«Researchers discover a potential new therapeutic strategy for
pancreatic cancer:
Researches have have isolated a subpopulation
of cancer - associated fibroblasts, which promote tumour growth.
Nearly 1 percent
of such adults will develop the disease within three years, says Lola Rahib, a scientist at the
Pancreatic Cancer Action Network, which supports the
research.
The
research team includes investigators from Mayo Clinic in Florida and Mayo Clinic SPORE in Pancreatic Cancer, one of three cancer centers in the U.S. to receive a Specialized Program of Research Excellence (SPORE) grant for pancreatic cancer from the National Cancer In
research team includes investigators from Mayo Clinic in Florida and Mayo Clinic SPORE in
Pancreatic Cancer, one of three cancer centers in the U.S. to receive a Specialized Program of Research Excellence (SPORE) grant for pancreatic cancer from the National Cancer
Pancreatic Cancer, one of three cancer centers in the U.S. to receive a Specialized Program of Research Excellence (SPORE) grant for pancreatic cancer from the National Cancer Inst
Cancer, one
of three
cancer centers in the U.S. to receive a Specialized Program of Research Excellence (SPORE) grant for pancreatic cancer from the National Cancer Inst
cancer centers in the U.S. to receive a Specialized Program
of Research Excellence (SPORE) grant for pancreatic cancer from the National Cancer In
Research Excellence (SPORE) grant for
pancreatic cancer from the National Cancer
pancreatic cancer from the National Cancer Inst
cancer from the National
Cancer Inst
Cancer Institute.
Longer term, they want to quickly diagnose additional
cancer types, including ovarian and
pancreatic cancers, which are fast - spreading and require early detection for a patient to survive, says Goda, who was recently appointed as a chemistry professor at the University
of Tokyo but will continue his
research with U.C.L.A..
This
research was supported by the National Institutes of Health, the US Department of Veterans Affairs, and Hirshberg Foundation for Pancreatic Cancer R
research was supported by the National Institutes
of Health, the US Department
of Veterans Affairs, and Hirshberg Foundation for
Pancreatic Cancer ResearchResearch.
The quest to improve survival
of children with a high - risk brain tumor has led St. Jude Children's
Research Hospital investigators to two drugs already used to treat adults with breast,
pancreatic, lung and other
cancers.
The study, funded by the
Pancreatic Cancer Research Fund, examined the role
of Hedgehog, whose usual job is to send signals to cells in embryos to divide and grow into the correct body parts.
Professor Eleanor Stride,
Cancer Research UK scientist at the University of Oxford, said: «We're especially excited about the potential this bubbly drink could have for hard to treat cancers like pancreatic cancer, where survival rates are low and better treatments are urgently n
Cancer Research UK scientist at the University
of Oxford, said: «We're especially excited about the potential this bubbly drink could have for hard to treat
cancers like
pancreatic cancer, where survival rates are low and better treatments are urgently n
cancer, where survival rates are low and better treatments are urgently needed.
Research from Rutgers
Cancer Institute of New Jersey shows that the «first in human» series of vaccine injections given directly into a pancreatic cancer tumor is not only well tolerated, but also suggests an «encouraging» period of stable di
Cancer Institute
of New Jersey shows that the «first in human» series
of vaccine injections given directly into a
pancreatic cancer tumor is not only well tolerated, but also suggests an «encouraging» period of stable di
cancer tumor is not only well tolerated, but also suggests an «encouraging» period
of stable disease.
According to a new «proof
of principle» study published in Aug. 27 issue
of Cancer Prevention Research, Moffitt Cancer Center researchers hope to improve pancreatic cancer survival rates by identifying markers in the blood that can pinpoint patients with premalignant pancreatic lesions called intraductal papillary mucinous neoplasms (I
Cancer Prevention
Research, Moffitt
Cancer Center researchers hope to improve pancreatic cancer survival rates by identifying markers in the blood that can pinpoint patients with premalignant pancreatic lesions called intraductal papillary mucinous neoplasms (I
Cancer Center researchers hope to improve
pancreatic cancer survival rates by identifying markers in the blood that can pinpoint patients with premalignant pancreatic lesions called intraductal papillary mucinous neoplasms (I
cancer survival rates by identifying markers in the blood that can pinpoint patients with premalignant
pancreatic lesions called intraductal papillary mucinous neoplasms (IPMNs).
For patients with locally advanced
pancreatic cancer, the combination
of chemotherapy and stereotactic ablative radiation (SABR) may be a promising treatment option, ultimately allowing them to undergo surgery that may not otherwise be an option, according to
research presented today at the American Society for Radiation Oncology's (ASTRO's) 56th Annual Meeting.
«Based on this
research, we are now conducting a first - in - human study combining the PARP inhibitor with radiation and chemotherapy in patients with locally advanced
pancreatic cancer, with an ultimate goal
of improving survival rates and treatment outcomes,» said Tuli.
«Considering that Florida ranks second in the number
of pancreatic cancer deaths that occur each year and the fact that
pancreatic cancer is projected to surpass breast, prostate, and colorectal
cancer and become the second leading cause
of cancer deaths by 2030, we are thrilled that our state is committed to investing in
pancreatic cancer research now,» said Permuth - Wey.
This new partnership, called the Florida Pancreas Collaborative, represents the first state - wide multi-
cancer center collaboration dedicated to conducting
research on IPMNs with the ultimate goal
of promoting the prevention and early detection
of pancreatic cancer.
«To move the needle forward toward prolonged survival and better treatment outcomes, our
research team created a combined investigational regimen for patients with locally advanced
pancreatic cancer,» said Richard Tuli, MD, PhD, a radiation oncologist in the Department of Radiation Oncology and a member of the Samuel Oschin Comprehensive Cancer Inst
cancer,» said Richard Tuli, MD, PhD, a radiation oncologist in the Department
of Radiation Oncology and a member
of the Samuel Oschin Comprehensive
Cancer Inst
Cancer Institute.
Jeanne Ruesch received the Margaret L. Hodges Leadership Award at the 31st annual Lombardi Gala for her advocacy on behalf
of research into
pancreatic cancer and other
cancers of the GI tract.
Cancer cells are on the move in the bloodstream in the very early stage of pancreatic cancer, and can be detected before cancer is diagnosed, according to research by the University of Michigan Health S
Cancer cells are on the move in the bloodstream in the very early stage
of pancreatic cancer, and can be detected before cancer is diagnosed, according to research by the University of Michigan Health S
cancer, and can be detected before
cancer is diagnosed, according to research by the University of Michigan Health S
cancer is diagnosed, according to
research by the University
of Michigan Health System.
In the longer online version
of the article you quote a
Cancer Research UK official singling out pancreatic cancer as a co
Cancer Research UK official singling out
pancreatic cancer as a co
cancer as a concern.
Together, these leading
cancer research organizations will attract new collaborators; improve diagnosis
of pancreatic cancer using big data; find new treatments for
pancreatic cancer; and support the next generation
of pancreatic cancer investigators.
This
research was supported by grants from the National Institutes
of Health (CA038548, CA140599, CA179991, CA180682), and by the AACR
Pancreatic Cancer Action Network, Vanderbilt GI SPORE and Vanderbilt - Ingram
Cancer Center.
Building on the successful outcomes
of their multi-year history, these leading
cancer research organizations will inspire new collaborators; improve diagnosis
of pancreatic cancer using big data; develop new treatments for
pancreatic cancer; and support the next generation
of pancreatic cancer investigators.
The first request for applications (RFA) will seek projects focusing on pre-clinical development
research to increase the number
of innovative and effective therapies to treat
pancreatic cancer.