«We found that intensive doses of statins carry the potential for clearing up the lipid debris that can lead to vision impairment in a subset
of patients with macular degeneration,» said Joan W. Miller, M.D., the Henry Willard Williams Professor and Chair of Ophthalmology at Harvard Medical School and Chief of Ophthalmology at Massachusetts Eye and Ear and Massachusetts General Hospital.
Any breakthrough in this area could be of immediate benefit to thousands
of patients with macular degeneration.
Not exact matches
The study included 18
patients, half
with age - related
macular degeneration and half
with Stargardt's
macular dystrophy, the leading causes
of blindness in adults and juveniles.
For example, a consortium
of research groups called the London Project to Cure Blindness aims to test RPE transplants from embryonic stem cells in
patients with macular degeneration this year.
Patients with age - related
macular degeneration who received seven or more eye injections
of the drug bevacizumab annually had a higher risk
of having glaucoma surgery, according to a study published online by JAMA Ophthalmology.
«We did a long series
of studies
with thousands
of patients and showed that this medication, Lucentis, actually reduced wet
macular degeneration,» Scheller recalls.
In July Genentech announced that the drug Lucentis stabilized or even improved vision in a yearlong clinical trial
of patients with so - called wet
macular degeneration, a form that involves overgrowth
of blood vessels.
«For example,
patients with Alzheimer's get protein deposits in the brain, and we can see similar deposits in the backs
of the eyes
of patients who have
macular degeneration,» said Friedlander.
Researchers only discovered this process in the late 1990s, but they've already begun dozens
of clinical trials to gauge whether infusing
patients with these small RNAs works against a range
of diseases, from lung infections to liver cancer to age - related
macular degeneration, a sight - stealing condition that mainly affects people over the age
of 50.
The 206
patients in the study shared a number
of characteristics, including stable, untreatable, age - related
macular degeneration in both eyes
with visual acuity no better than 20/80 but no worse than 20/800, along
with good peripheral vision.
Age - related
macular degeneration is extremely prevalent,
with as many as one in 10
patients over the age
of 65 affected to some degree.
Roughly 20 percent
of patients with age - related
macular degeneration suffer from abnormal blood vessel growth and vascular leakage, says Campochiaro, and so may be helped by this new therapy, if it proves to work in clinical trials.
It is important for all
patients (and family members
of patients)
with macular degeneration to know that although the disease can injure the central vision
of both eyes severely enough to render one «legally blind,» it is extremely uncommon to cause complete blindness in even a single eye.
Although exciting and promising, none
of these experimental treatments has yet been demonstrated to be
of significant benefit to
patients with typical late - onset
macular degeneration.
In 1997, the mainstays
of therapy for
patients with macular degeneration include daily monitoring
of the integrity
of their central vision (usually by viewing a simple printed grid) as well as periodic visits to their eye doctor.
In fact, although only 10 percent
of patients develop new blood vessels, this complication is responsible for most
of the legal blindness associated
with macular degeneration.
Researchers at Massachusetts Eye and Ear / Harvard Medical School and the University
of Crete have conducted a phase I / II clinical trial investigating the efficacy
of statins (cholesterol - lowering medications) for the treatment
of patients with the dry form
of age - related
macular degeneration (AMD)-- the leading cause
of blindness in the developed world.
The researchers detected RPE cells in the eye
of the
patient with Stargardt disease but not in the
patient with age - related
macular degeneration.
Takahashi's team transplanted retina cells made from the
patient's skin cells into the
patient's eye
with the goal
of treating
macular degeneration.
A case review recently published in The New England Journal
of Medicine describes how three elderly
patients with macular degeneration were blinded after they were treated at a Florida clinic (FL, USA).
«This is the first human trial
of this novel stem cell - based implant, which is designed to replace a single - cell layer that degenerates in
patients with dry age - related
macular degeneration,» says lead author and surgeon for the study Dr. Amir H. Kashani, assistant professor
of clinical ophthalmology at the Keck School
of Medicine
of USC.
As a retinal physician, Dr. Handa (co-principal investigator on this project) has witnessed the detrimental impact
of vision loss on
patients with age - related
macular degeneration (AMD).
A pilot study assessing the safety and feasibility
of the transplantation
of autologous iPSC - derived retinal pigment epithelium (RPE) cell sheets in
patients with exudative (wet - type) age - related
macular degeneration was launched in Japan in August 2013.
They were financed by Advanced Cell Technology, a biotech company
with laboratories in Marlborough, Massachusetts, that recently won approval from the U.S. Food and Drug Administration to test the treatment in 24
patients suffering from either dry advanced
macular degeneration, or a juvenile form
of the disease known as Stargardt's.
• Emory University Hospital Department
of Radiology — The utilization
of CT imaging in
patients who present to the emergency department with acute abdominal pain, 2005 — 2007 • Emory University Hospital Department of Radiology — CTA for the pre-operative evaluation of living related liver donors, 2001 — 2001 • Emory University Hospital Department of Geriatrics — Transferring behavior research into nursing home practice (this study is prospective and is being funded by the National Institute on Aging), 2000 — 2002 • CTA for the Pre-Operative Evaluation of Living Related Liver Donors: A Comparison of Multi-Detector CT and Digital Subtraction Angiography, Radiological Society of North America, 2001 • Characteristics of Age - Related Macular Degeneration Patients with Low Vision Receiving Visual Rehabilitation, American Academy of Ophthalmology and the Journal of Rehabilitation Research and Developme
patients who present to the emergency department
with acute abdominal pain, 2005 — 2007 • Emory University Hospital Department
of Radiology — CTA for the pre-operative evaluation
of living related liver donors, 2001 — 2001 • Emory University Hospital Department
of Geriatrics — Transferring behavior research into nursing home practice (this study is prospective and is being funded by the National Institute on Aging), 2000 — 2002 • CTA for the Pre-Operative Evaluation
of Living Related Liver Donors: A Comparison
of Multi-Detector CT and Digital Subtraction Angiography, Radiological Society
of North America, 2001 • Characteristics
of Age - Related
Macular Degeneration Patients with Low Vision Receiving Visual Rehabilitation, American Academy of Ophthalmology and the Journal of Rehabilitation Research and Developme
Patients with Low Vision Receiving Visual Rehabilitation, American Academy
of Ophthalmology and the Journal
of Rehabilitation Research and Development, 1998