Not exact matches
Researchers studying two generations
of a family affected by
pediatric acute lymphoblastic leukemia (ALL) have identified an inherited variation in the ETV6 gene that is associated with an increased risk
of developing the disease.
[3]-RRB- However, the presence
of the Philadelphia (Ph) chromosome is not sufficiently specific to diagnose CML, since it is also found in
acute lymphoblastic leukemia [4](aka ALL, 25 — 30 %
of adult cases and 2 — 10 %
of pediatric cases) and occasionally in
acute myelogenous
leukemia (AML).
The use
of minimal residual disease (MRD) provided a more objective measure
of induction failure in patients with
pediatric acute lymphoblastic leukemia (ALL) than did morphology, according to the results
of a study published recently in the Journal
of Clinical Oncology.
Whole genome and whole transcriptome sequencing
of 31
pediatric Asian patients with T - cell
acute lymphoblastic leukemia found that about 10 percent had the same alteration in a non-coding region
of DNA.
A phase I / II trial
of KTE - C19 (anti-CD19 CAR T cells) for
pediatric and adolescent subjects with relapsed / refractory B - precursor
acute lymphoblastic leukemia -LRB-
Changes in an epigenetic mechanism that turns expression
of genes on and off may be as important as genetic alterations in causing
pediatric acute lymphoblastic leukemia (ALL), according to a study led by scientists at St. Jude Children's Research Hospital and published in the June 10 online edition
of the Journal
of Clinical Investigation.