Sentences with phrase «of pharmacological research»

These are the conclusions of the Risk and Prevention Study Collaborative Group, a collective of Italian researchers led by Maria Carla Roncaglioni (Mario Negri Institute of Pharmacological Research, Milan, Italy).

Vinkers, C. H.; van Bogaert, M. J.; Klanker, M.; Korte, S. M.; Oosting, R.; Hanania, T.; Hopkins, S. C.; Olivier, B.; Groenink, L. Translational aspects of pharmacological research into anxiety disorders: the stress - induced hyperthermia (SIH) paradigm.

Not exact matches

Says DiDonato: «We are very happy that our research was able to assist in the pharmacological characterization of RG3039 and contribute to dose selection and exposure estimates for the first studies with RG3039 in human subjects.

Roland Griffiths of Johns Hopkins, for example, who has been doing pharmacological research for more than three decades, never had a project scrutinized as thoroughly by his institution's review board and the FDA as his 2006 psilocybin study was.

New avenues of research could include the effects of reducing environmental stress, as well as whether pharmacological agents might be able to reverse the genetic alternations in vulnerable children before the disorder develops.

Jordi Mestres, coordinator of the IMIM and UPF research group on Systems Pharmacology at the Biomedical Informatics Program (GRIB) states «With this study we have contributed to complementing the detection of these quite unstable fragments, with information on the mechanism of action of the drug, based on three aspects: similarity to other medicines, prediction of their pharmacological profile, and interference with specific biological pathways.

«Our research shows that targeting cannabinoid receptors in the periphery with pharmacological inhibitors that do not reach the brain holds promise as a safe therapeutic approach for the treatment of overeating and diet - induced obesity,» said Nicholas V. DiPatrizio, an assistant professor of biomedical sciences in the School of Medicine, who led the research project.

This article clarifies the research conducted to identify the relationship between pharmacological treatments administered to the patient and the role of the mind in the overall patient health.

Pozzo - Miller reflects that this new research on LM22A - 4, combined with prior studies from the Katz lab, provides hope that at least some neurological and cognitive deficits in individuals with Rett could be improved by pharmacological treatment even after the onset of symptoms.

The team also features a post-doctoral fellow (Jeremy Miyauchi in Pharmacological Sciences), a researcher who recently received his PhD (William Berger in Chemistry), a graduate student Matthew Elmes, a research technician Liqun Wang, and undergraduate students Brian Ralph, Kwan - Knok Leung, and Joseph Sweeney, all from the Department of Biochemistry and Cell Biology.

On the other hand, the delay «could be a risk for many of us, who plan to apply for international grants that cover longer time projects,» adds Giuseppe Remuzzi, a kidney transplant researcher at the Mario Negri Institute for Pharmacological Research and president of the International Society of Nephrology.

It describes itself as «a peer reviewed journal aiming to communicate high quality research articles, short communications, and reviews in the field of natural products with desired pharmacological activities.»

«When we had the data, we were quite surprised by the amount,» says Roberto Fanelli, one of the study's authors and head of the Department of Environmental Health Sciences at the Mario Negri Institute for Pharmacological Research in Milan.

Advances in biomedical and pharmacological research have continued to benefit humanity by producing drugs that either alleviate symptoms of disease or provide a cure.

The TTUHSC El Paso research team now plans to test pharmacological compounds that can inhibit JNK3 in mice to identify drug compounds that will slow the progression of the disease and reduce the overall burden of this illness in patients.

«For translation to humans, it would be important to know if pharmacological enhancement — ideally of the specific GABA receptor — can alleviate the peripheral hypersensitivity to touch, especially in young children who may be in a critical period of vulnerability,» says Takao Hensch, a neuroscientist at Harvard University who was not involved in the research.

One of the main challenges in finding a treatment for the disease in the future is the research and development of pharmacological therapies capable of activating the Crtc1 protein, with the aim of preventing, slowing down or reverting cognitive alterations in patients.

Prof. Marine and his research team also identified a pharmacological way of restoring the expression of FES in human melanoma.

Our results establish planarians as an experimentally tractable animal model for research into the pathophysiology of acute porphyrias, and potentially for the identification of novel pharmacological interventions capable of alleviating porphyrin - mediated photosensitivity or decoupling dieting and fasting from disease pathogenesis.

The research is described in an article by Chorniy and Kitashima titled «Sex, Drugs, and ADHD: The Effects of ADHD pharmacological treatment on teens» risky behaviors» published online this month by the journal Labour Economics.

Cell lines provides solution for manufacture of therapeutic and diagnostic protein and for applications in drug screening, pharmacological research and toxicological studies

After receiving a master degree in Biotechnology at the University of Verona (Italy) in 1998, I joined the neuroscience centre of GlaxoSmithKline (GSK), a large research - based pharmaceutical company based in Verona (Italy) and Harlow (UK), where I pioneered the use of functional magnetic resonance imaging (MRI) to describe the neural substrates modulated by pharmacological agents, a line of research that I also pursued to obtain a PhD degree in biomedical imaging with the University of Verona.

1994 - 1997 Trainee, Mario Negri Institute for Pharmacological Research, Bergamo, Italy, in leave of absence to Ospedale San Raffaele, Milano, Italy.

The research, published in the Journal of Bone and Mineral Research, is an important step toward an effective pharmacological treatment for MHE, a rare genetic condition that affects about 1 in 50,000 people woresearch, published in the Journal of Bone and Mineral Research, is an important step toward an effective pharmacological treatment for MHE, a rare genetic condition that affects about 1 in 50,000 people woResearch, is an important step toward an effective pharmacological treatment for MHE, a rare genetic condition that affects about 1 in 50,000 people worldwide.

American Federation for Aging Research Fellow at the Albert Einstein College of Medicine in New York; USA From: Salt Lake City, USA Prize Category: Translational Medicine Essay: A Novel Target for Pharmacological Intervention in an Untreatable Human Disease

S1P is a signaling lipid mediator, which is generated inside the cells by sphingosine kinases, exported out of the cells, then bind and signal through five S1P specific G - protein coupled receptors (S1PR1 - 5), coined «inside - out signaling» (Takabe K et al, Pharmacological Reviews 2008, Takabe K et al, Journal of Lipid Research 2014).

A particularly distinctive aspect of my research has been the study of brain functional connectivity and its pharmacological modulation, an area that my group has pioneered.

Research Coordinator of the Negri Bergamo Laboratories of the Mario Negri Institute for Pharmacological Research.

The goal of this research is to employ a variety of techniques, including electroencephalography (EEG), event - related potentials, functional magnetic resonance imaging (fMRI), positron emission tomography (PET), molecular genetics, as well as stress and pharmacological manipulations, to advance the understanding of anhedonia.

Every issue of Trends in Pharmacological Sciences contains succinct articles on the most exciting recent developments in pharmacology and toxicology research: topics covered in the journal range from molecular to behavioural pharmacology, and from current techniques to theoretical pharmacology.

Speaking at the British Pharmacological Society's Winter Meeting in Brighton on 18 December, Christine Mummery, Professor of Developmental Biology at Leiden University Medical Centre in The Netherlands, predicts that what is currently a small and sparsely funded research area will boom in coming years.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

Despite more than half a century of intensive research, however, insulin - degrading enzyme has remained «an especially elusive pharmacological target,» biochemist Malcolm Leissring of the Scripps Research Institute and neurobiologist Dennis Selkoe of Harvard Medical School wrote in a commentary that accompanies the Nature research, however, insulin - degrading enzyme has remained «an especially elusive pharmacological target,» biochemist Malcolm Leissring of the Scripps Research Institute and neurobiologist Dennis Selkoe of Harvard Medical School wrote in a commentary that accompanies the Nature Research Institute and neurobiologist Dennis Selkoe of Harvard Medical School wrote in a commentary that accompanies the Nature article.

J.P.S. was a recipient of an NIH Research Training in Pharmacological Sciences predoctoral training grant and UCLA dissertation year fellowship.

Is isn't that its just a mouthful to say, it may also have a laundry list of pharmacological benefits including: an powerful antioxidant, anti-cancer, anti-diabetic, and an anti-inflammatory agent (according numerous research studies).

Cooking these greens reduces the bioavailability of isothiocyanates by destroying the enzyme needed to produce them from other substances in collard greens, according to an article published in «Pharmacological Research» in March 2007.

From 2001 - 2010 he was an Assistant Professor of Oncology at Cornell, where his research efforts were focused on clinical and translational projects involving cancer control and pharmacological validation of new agents.

It has been extensively researched in Europe through chemical analysis, study of pharmacological properties and clinical experimentation.

About Blog The Journal of Neuropsychology publishes original contributions to scientific knowledge in neuropsychology including clinical and research studies with neurological, psychiatric and psychological patient populations in all age groups, behavioural or pharmacological treatment regimes, cognitive experimentation and neuroimaging.

Bisson also suggested the future for PTSD treatment research must include well - designed trials and an exploration of combination treatments — particularly involving both psychotherapy and pharmacological agents.

Dr. Salisbury discusses research in which in utero exposure to maternal depression (with and without pharmacological treatment) was found to have some apparent influence on infants» postnatal behavioral outcomes at one month following birth, reinforcing the importance of focusing on remission of maternal depression symptoms during pregnancy.

Her research interests focus on studying the neural correlates of PTSD using neuroimaging (functional magnetic resonance imaging) and treatment outcome research examining various pharmacological and psychotherapeutic methods.