One of the main challenges in finding a treatment for the disease in the future is the research and development
of pharmacological therapies capable of activating the Crtc1 protein, with the aim of preventing, slowing down or reverting cognitive alterations in patients.
But Strange cautioned that developing a comprehensive knowledge of the biological processes that underlie both resilience and regeneration is essential to the success
of any pharmacological therapy.
Not exact matches
One woman commented that there was a lack
of information about non-
pharmacological pain relief, and complementary
therapies «were not encouraged» whereas
pharmacological pain relief was «pushed at classes».
Perinatal mood disorders are treatable, and a range
of pharmacological (medicines), psychological (talking
therapy) and social
therapies (support groups) have been validated as effective treatments for the range
of perinatal mood disorders.
The identification
of these opiate - induced changes offers the best hope for developing more effective
pharmacological targets and
therapies to prevent or reverse the effect
of opiate exposure and addiction.
Dr Reinders added: «We now want to understand the neurobiological underpinnings
of DID and whether psychological or
pharmacological therapies are more effective in treating the disorder.»
This could be important for the development
of new
pharmacological therapies.
This has implications for how we think about the underlying behavioral differences in autism and implications for how we develop both behavioral or
pharmacological therapies to improve the lives
of those with autism.»
The results, published in the current issue
of Human Molecular Genetics, open the door for pursuing gene editing in nonhuman primates as models for new
therapies, including
pharmacological, gene - and stem cell - based
therapies, said Keith Latham, MSU animal science professor and lead author
of the study.
In parallel to this cell
therapy application, keratynocytes and melanocytes derived from pluripotent stem cells will be used for pathological modelling
of genodermatoses allowing identification
of new disease - specific
pharmacological treatments
Besides their stem cell properties, CSCs have become a focus
of pharmacological studies due to their resistance to many cancer
therapies.
Dr. Elias and the OCAR primarily focus on understanding why ERP works (e.g., fear tolerance versus fear habituation; the roles
of guilt, willingness, and acceptance; patterns
of brain activation during exposure; functional connectivity among brain regions), tailoring treatment to the individual (e.g., elucidation
of predictors
of response and their underlying processes / mechanisms and neural correlates; rigorous diagnostic characterization
of obsessive compulsive related disorders), and evaluating innovative treatments and augmentation strategies (e.g., acceptance and commitment
therapy; optimization
of inhibitory learning;
pharmacological augmentation).
Project: Development
of Pharmacological Chaperone
Therapy for Inherited Primary and Juvenile Open Angle Glaucoma
Although some people with hoarding problems may respond well to
pharmacological strategies used in the treatment
of OCD — such as SSRIs (selective serotonin reuptake inhibitors)-- the most effective treatment, says Dr Jeffreys, is behavioural
therapy.
Reviews with a favourable conclusion about psychological
therapies (vs
pharmacological interventions) are at high risk for a spin in conclusions (OR = 8.31 (1.41 to 49.05)-RRB-, whereas favourable conclusions about effects
of pharmacological interventions showed no spin in our sample (OR = 1.00 (0.16 to 6.14).
Also the conclusion
of equal effects
of psychological
therapies and
pharmacological interventions does not face a risk
of spin (OR = 0.12 (0.01 to 1.08).
The reviews and meta - analyses addressed anxiety disorders (n = 42), depressive disorders (n = 48), and / or personality disorders (n = 13), and allowed conclusions about the following interventions: 59 reviews compared psychological
therapies with other forms
of psychological
therapies, and 36 compared psychological
therapies with
pharmacological interventions.
Pharmacological treatment as an adjunct to
therapy for a variety
of disorders: Depression, BiPolar, ADHD, Anxiety, Panic, Psychosis, Eating Disorders, OCD.
Patients often benefit from a combination
of therapy and medication, which synergistically enhance the response to both therapeutic and
pharmacological intervention.
However, when stratified by quality
of studies, the Cochrane review found no statistically significant evidence in methodologically robust RCTs that exercise was more effective than psychological or
pharmacological therapies.46 Nevertheless, we still found that depressive symptoms are associated with lower PA levels in individuals at high risk
of CVD, which highlights the importance
of screening and optimising conventional depression management48 to reduce depressive symptoms, which could help lower CVD risk.3 4
In fact, while the American Academy
of Pediatrics recommends behavior
therapy support as the first line
of treatment for preschool - age children with ADHD, limited availability
of clinicians, cost and challenges in transportation and child care — as well as reliance on
pharmacological drugs — mean few families access such
therapy for themselves and their children.
Therapists also use multimodal
therapy, which is a combination
of psychosocial and
pharmacological therapy.