A major clue to understanding schizophrenia came with the development
of phencyclidine (PCP) in 1956.
Not exact matches
The American Academy
of Pediatrics advises against the use
of marijuana during pregnancy and while breastfeeding: «Street drugs such as PCP (
phencyclidine), cocaine, and cannabis can be detected in human milk, and their use by breastfeeding mothers is
of concern, particularly with regard to the infant's long - term neurobehavioral development and thus are contraindicated.»
To demonstrate the chip's efficacy in modeling disease, the team doped different regions
of the brain with the drug
Phencyclidine hydrochloride — commonly known as PCP — which simulates schizophrenia.
Gozzi, A. *, Herdon, H., Schwarz, A., Bertani, S., Crestan, V., Turrini, G., Bifone, A. Pharmacological stimulation
of NMDA receptors via co-agonist site suppresses fMRI response to
phencyclidine in the rat (2008) Psychopharmacology, 201 (2), pp. 273 - 284.
Gozzi, A. *, Large, C.H., Schwarz, A., Bertani, S., Crestan, V., Bifone, A. Differential effects
of antipsychotic and glutamatergic agents on the phMRI response to
phencyclidine (2008) Neuropsychopharmacology, 33 (7), pp. 1690 - 1703.
Phencyclidine - Induced Decrease
of Synaptic Connectivity via Inhibition
of BDNF Secretion in Cultured Cortical Neurons % U http://cercor.oxfordjournals.org/content/early/2012/03/30/cercor.bhs074.short.
Title: Activation
of thalamocortical networks by the NMDA receptor antagonist
phencyclidine.
Title: Clozapine Reverses
Phencyclidine - Induced Desynchronization
of Prefrontal Cortex through a 5 - HT1A Receptor - Dependent Mechanism Author: L. Kargieman et al..
«Differential effects
of antipsychotic and glutamatergic agents on the phMRI response to
phencyclidine»
Evaluation
of cognitive and social functions in rats subchronically treated with
phencyclidine.
Objective: Exposure to
phencyclidine (PCP) has been used as an inducing condition in various animal models
of schizophrenia.
Dopamine supersensitivity occurs in schizophrenia and other psychoses, and after hippocampal lesions, antipsychotics, ethanol, amphetamine,
phencyclidine, gene knockouts
of Dbh (dopamine
Further investigation revealed that the researchers failed to report that the MSG was frequently vomited before it could be absorbed, that the monkeys were under anesthesia with a powerful glutamate receptor antagonist (
phencyclidine), and that the areas
of the brain shown in micrographs were areas
of the hypothalamus known to be unaffected by glutamate.
This is especially apparent when enemies such as bandits and mutants are able to tumble, flip, and jump at you like kung - fu gymnasts on
phencyclidine, and all you can do is wave the butt
of your gun at them and hope.
Drug tests monitor marijuana, cocaine, amphetamine, opiate, and
phencyclidine use and may only be performed by laboratories that are certified by the Department
of Health and Human Services.