Sentences with phrase «of phosphatidylinositol»

Research in the Emerling Lab is focused on phosphoinositide signaling, in particular the role of the phosphatidylinositol -5-phosphate 4 - kinases (PI5P4Ks) in cancer metabolism.

Association of phosphatidylinositol 3 - kinase with a specific sequence of the T cell receptor zeta chain is dependent on T cell activation.

Western blot analyses with phospho - specific antibodies suggested that stretching induces phosphorylation of ERK of the MAP kinase pathway, but did not induce phosphorylation of phosphatidylinositol 3 - kinase.

Interactome mapping of the phosphatidylinositol 3 - kinase - mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor - 1 as a new glycogen synthase kinase - 3 interactor

AKT is a downstream effector of phosphatidylinositol 3 - kinase (PI3K) and a critical mediator of mammalian target of rapamycin (mTOR) activity (6).

Roles of phosphatidylinositol 3 - kinase and osteopontin in steatosis and aminotransferase release by hepatocytes treated with methionine - choline - deficient medium.

Interestingly, PDGF - BB overexpression by modified hDPSCs enhanced the recruitment of hDPSCs both in vitro and in vivo via the activation of the phosphatidylinositol 3 kinase (PI3K) / Akt signaling pathway and, in combination with secreted vascular endothelial growth factor (VEGF), enhanced in vitro angiogenesis.

In turn it induces the cleavage of phosphatidylinositol - 4, 5 - diphosphate (PIP2) to the production of two second messengers, inositol 1,4,5 - triphosphate (IP3) and diacyl glycerol (DAG)[41].

Inhibitors (LY294002, wortmannin, and deguelin) of phosphatidylinositol 3 - kinases (PI3K) and AKT, but not inhibitors of MEK1 / 2, JNK, and p38 - MAPK abolished the ActD - induced p53 expression in diverse cell types.