Sentences with phrase «of phospholipase»

[48] Mutations in GNAQ or GNA11 occur in the majority of uveal melanomas and drive oncogenesis via activation of the phospholipase C / protein kinase C (PKC), Rho / Rac, and Yes - associated protein pathways.

The drug worked in neurons incubating in a dish to prevent activation of phospholipase Cγ1 via TrkB.

The scientists confirmed that the drug was inhibiting activation of phospholipase Cγ1 in the mice.

Not exact matches

They suggest that keeping choline levels low outside endosomes promotes the activity of an enzyme, phospholipase D, that cleaves multiple lipids and, in so doing, has a direct effect on vesicle lipid composition and thus destination.

C. krusei, they found, has few copies of gene families associated with pathogenesis in C. albicans, including oligopeptide transporters, aspartyl proteases, and phospholipase B genes.

The cause of the subsequent seizures appeared to be phospholipase C (gamma) 1, an enzyme spurred into action by TrkB activation.

Then, when they infused it into the blood of the mice, pY816 reduced by half the amount of activated phospholipase Cγ1 in the brain.

Gatti, C., Cantelmi, M. G., Brunetti, M., Gaiti, A., Calderini, G., and Teolato, S. Effect of chronic treatment with phosphatidyl serine on phospholipase A1 and A2 activities in different brain areas of 4 month and 24 month old rats.

Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16.

More research will be needed to understand the significance of the relationship of FcRY and FcRn to their respective homologs: phospholipase receptors and MHC molecules.

In a paper appearing online today in the journal Nature, the team reports the results of biochemical assays which demonstrate that mZuc has no phospholipase activity and that it does in fact possess nuclease activity.

Phospholipase D facilitates efficient entry of influenza virus, allowing escape from innate immune inhibition.

Role of phosphorylation and basic residues in the catalytic domain of cytosolic phospholipase A2α in regulating interfacial kinetics and binding and cellular function.

Function, activity, and membrane targeting of cytosolic phospholipase A2ζ in mouse lung fibroblasts.

Identification of the Expressed Form of Human Cytosolic Phospholipase A2β (cPLA2β) cPLA2β3 IS A NOVEL VARIANT LOCALIZED TO MITOCHONDRIA AND EARLY ENDOSOMES.

TNF - α Inhibits Macrophage Clearance of Apoptotic Cells via Cytosolic Phospholipase A2 and Oxidant - Dependent Mechanisms.

Activation of cytosolic phospholipase A2α in resident peritoneal macrophages by Listeria monocytogenes involves listeriolysin O and TLR2.

Genetic ablation of calcium - independent phospholipase A2β causes hypercontractility and markedly attenuates endothelium - dependent relaxation to acetylcholine.

Targeting of Protein Kinase C - ϵ during Fcγ Receptor - dependent Phagocytosis Requires the ϵC1B Domain and Phospholipase C - γ1.

Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase, inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting

His Ph.D. thesis topic was the implication of prostanoids and phospholipases A2 in the biology of osteoclasts.

Activated heterotrimers have a wide array of effectors including adenylate cyclase (AC), phospholipase C - beta, PI 3 - kinases, GIRK channels and RhoA

Furthermore, anti-CD3 mAb induced phosphorylation of ERK, phospholipase C γ (PLC - γ), and SLP76, all were unaltered in Gasp - deficient DP thymocytes (Fig. 5F).

Plus, the increased Ca + + levels between the cells are related to the activation of the enzyme called «Phospholipase A2».

Tnf - a stimulates the production of Arachidonic Acid via Phospholipase A2 from our cellular lipid stores.

A study on Mercury's Link to Heart Disease Begins in Blood Vessel Walls in the International Journal of Toxicology in 2007 found that mercury's link to heart disease can be traced to activation of an enzyme, phospholipase D (PLD), which triggers a process leading to plaque buildup in blood vessel walls.

More widely present in unwanted inflammatory problems is overactivity of the enzyme phospholipase A2 (PLA2).

Some of these benefits appear to take place through the blocking of selectins and from inhibition of an enzyme called phospholipase A2.

«Inhibition of platelet phospholipase A2 activity by catuaba extract suggests anti-inflammatory properties.»

Potentially useful prognostic indicators that are pancreas specifi c include assay of trypsinogen activation peptide (TAP), trypsin complexed with inhibitors, and phospholipase A2.

One of the serine / threonine protein kinases (JGI ID: 432478) was upregulated nearly sevenfold in the future ocean condition treatment, whereas a phosphoinositide phospholipase C (JGI ID: 95985) increased expression sixfold (see electronic supplementary material, table S5).