Sentences with phrase «of phosphorylation sites»

We have identified tyrosine and serine / threonine phosphorylation sites of Eph receptors and ephrins using mass spectrometry and investigated the signaling role of these phosphorylation sites.

Characterization of phosphorylation sites in the cytoplasmic domain of the 300 kDa mannose -6-phosphate receptor

For his Ph.D, he characterized the evolutionary dynamics of phosphorylation sites for functional phospho - proteomics and to understand the evolution of phosphorylation - based cell signaling.

Not exact matches

In mice with a genetic deletion of DARPP - 32 or with point mutations in phosphorylation sites of DARPP - 32, the effects of D - amphetamine, LSD, and PCP on two behavioral parameters — sensorimotor gating and repetitive movements — were strongly attenuated.

«Now, we need to better understand how this works at the molecular level so we can perhaps design therapeutics to prevent phosphorylation of that site.»

The sequence similarity between MAD - 3 and pp40 includes a casein kinase II and consensus tyrosine phosphorylation site, as well as five repeats of a sequence found in the human erythrocyte protein ankyrin.

A key step in many signaling pathways is «phosphorylation,» the activation or deactivation of a protein by adding a phosphate group at certain sites on the protein.

In the past 27 years, we have found that this cycling sugar modification of proteins — called O - linked N - acetylglucosamine, or O - GlcNAc — is nearly as common as protein phosphorylation and often competes with it at the same or proximal sites on proteins to regulate nearly every cellular process in response to nutrients and stress.

Src - mediated caveolin - 1 phosphorylation affects the targeting of active Src to specific membrane sites.

Zhang, Y. and Wolf - Yadlin, A. and Ross, P. L. and Pappin, D. J. and Rush, J. and Lauffenburger, D. A. and White, F. M. (2005) Time - resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.

Specifically, they are interested in those genes that are involved in tyrosine phosphorylation — the attachment of a phosphate group (a phosphorous surrounded by oxygen atoms) to distinct sites in protein chains where there is a tyrosine residue.

Mutation of Hof1 PEST motif phosphorylation sites leads to retention of Hof1 at the bud neck and a decrease in the rate of myosin contraction.

They mapped the spatial relationship of 3,509 proteins and 225 distinct phosphorylation sites.

Johnson and Cole Labs uncover a new role for a tumor suppressor in DNA repair (11/15/16) Work from the Johnson lab previously showed that E2F1, a critical transcription factor target of the retinoblastoma (Rb) tumor suppressor protein, localizes to sites of both UV and IR induced DNA damage in a phosphorylation dependent manner.

For example, our past work showed that two conserved tyrosine phosphorylation sites in the juxtamembrane segment of the Eph receptors not only mediate association with binding partners but also regulate receptor kinase activity.

Despite evidence for divergence at several loci, certain 1a characteristics were preserved including the length of the alternative reading frame / F protein (ARF / F) gene, and a subtype 1a - specific phosphorylation site in NS5A (S349).

Previous studies have shown that the closely related Oct1 is dynamically phosphorylated [38], and site - directed mutagenesis of potential phosphorylation sites in Oct4 indicated a potential role for phosphorylation in regulating homodimer complex formation [18].

Mutation of a potential protein kinase A (PKA) phosphorylation site has dramatic consequences on Oct4 transactivation potential.

In the yeast cells, they showed that the more effectively they prevented full aggregation — by adding more sites mimicking phosphorylation — the more robustly colonies of the cells would grow.

As a first step towards identifying such post-translational modifications, we performed bioinformatic analysis of the Oct4 protein sequence and identified several potential phosphorylation sites.

Thus, phosphorylation at this site likely causes steric and electrostatic disruption of this specific Oct4 homodimer - DNA configuration (the PORE homodimer), but not of the MORE homodimer configuration or Oct4 heterodimer complexes.