Sentences with phrase «of photoreceptor function»

This Clinical Statement provides recommendations for patients with inherited retinal degenerations, which comprise a wide range of genetically and phenotypically heterogeneous diseases associated with progressive loss of photoreceptor function and visual loss.

Not exact matches

He suspects that transplanted cells are actually restoring the function of «dormant» photoreceptors.

The retinal pigment epithelium (RPE) is a single layer of cells that accomplishes multiple functions, such as providing survival molecules that prevent photoreceptors from dying.

Instead of catching light on film, digital cameras use an array of light - sensitive photodiodes that function much like the photoreceptors in an eye.

The six previously known fly rhodopsins account for the full function of photoreceptor cells in the fly's eyes, so although the fruit fly genome contained the sequence of a seventh rhodopsin, the role of Rh7 was unclear.

These included impaired function of retinal pigment epithelium and subsequent blindness due to photoreceptor atrophy and death.

Lack of protein - tyrosine sulfation disrupts photoreceptor outer segment morphogenesis, retinal function and retinal anatomy.

The RPE is a single layer of cells lining the back of the retina that is vital to the functioning of the retinal photoreceptor cells, and thus vision itself.

With age, our eyes accumulate waste in retinal pigment epithelium (RPE), which supports the life and function of photoreceptors (light sensitive cells in the eye); in advanced stages, RPE and photoreceptors die.

While preservation of the ONL is evidence for a neuroprotective role for hNPCctx and GDNF within the retina, maintenance of visual function at the level observed in this study suggests at least partial retention of photoreceptor structure necessary for visual processing, particularly that associated with cones.

One can imagine that loss of function of any of the gene products along this complex pathway could lead to severe consequences for the survival of the photoreceptor (PR) cells in the eye.

Of note, while vision rescue requires preservation of some functional photoreceptors, the mere presence of photoreceptor cells in the ONL of transplanted RCS rats does not assure function [61Of note, while vision rescue requires preservation of some functional photoreceptors, the mere presence of photoreceptor cells in the ONL of transplanted RCS rats does not assure function [61of some functional photoreceptors, the mere presence of photoreceptor cells in the ONL of transplanted RCS rats does not assure function [61of photoreceptor cells in the ONL of transplanted RCS rats does not assure function [61of transplanted RCS rats does not assure function [61].

It is likely that those cells would then support the function of the very important photoreceptor cells in the retina.

The retinal pigment epithelium (RPE) is a monolayer of cells, residing at the back of the eye between Bruch's membrane and the retina, which is essential for photoreceptor function and survival.

As a monolayer of cells critical to photoreceptor function and survival, the RPE is an ideally accessible target for cellular therapy.

DHA is well - regarded in improving the nerve impulses transmitted across the eye structure while beta carotene can help enhance the function of photoreceptors inside the eye.

Subretinal injections of adeno - associated virus vectors expressing RPE65 resulted in restoration of rod photoreceptor function and improved visual function, first in dogs [61, 62] and subsequently in humans [63 — 65].

A subsequent electroretinography study identified an initial reduction of the cone photoreceptor function which led to the condition being re-classified as a cone - rod dystrophy (CRD), rather than a rod - led PRA, and the disease was termed CORD1 for cone - rod degeneration 1 [36].

The gene product's precise role is not currently understood but it is thought to anchor regulatory complexes at the photoreceptor connecting cilium, which acts as a bridge between the inner and outer segments of photoreceptor cells [43] as well as having functions in disk morphogenesis [42] and in the structure of the ciliary axoneme [44].

Intriguingly, an identical homozygous mutation was identified in a human patient with recessive retinitis pigmentosa, the human equivalent of PRA, and established the novel retinal gene, PRCD, as an important gene for the maintenance of rod photoreceptor structure and function across species.

ERG abnormalities are evident by 5 — 6 weeks of age and cell degeneration is present by 4 months, suggesting the mutant protein has a toxic gain of function that severely compromises the early stage of development of the photoreceptors.

Whereas the genes implicated in early - onset diseases are those necessary for the correct development of photoreceptors the genes associated with later - onset forms of disease are those necessary for the long - term maintenance and function of these cells.

In general, PRAs are characterized by initial loss of rod photoreceptor function followed by that of the cones and for this reason night blindness is the first significant clinical sign for most dogs affected with PRA.

Evaluation of retinal function in 15 Swedish vallhund dogs (nine dogs at Stage 2, two dogs at Stage 3, and four normal control dogs) by electroretinography revealed a decrease of both rod and cone photoreceptor - mediated function in Stages 2 and 3 (Fig. 3).

Electroretinography revealed a gradual loss of both rod and cone photoreceptor - mediated function in Stages 2 and 3 of the disease.