The more copies
of the pigment gene a coral has, the brighter its range of potential colors.
Genetic transmission of deafness in dogs with the recessive alleles
of this pigment gene, such as the Dalmatian (which is homozygous for sw), is less clear.
Not exact matches
While we both made use
of the dominant
gene for hair and eye
pigment, in us somewhere was the recessive
genes for blonde and blue.
Three
of the darker - skin
gene variants appear to have evolved from variants linked with less
pigment.
Luckily, along came Armstead and his colleagues, who were working to precisely locate the sequence
of a
gene called staygreen (sgr) in the meadow grass Festuca pratensis, some variants
of which remain green in drought and other unfavorable conditions because they are unable to break down a green
pigment.
This
gene, which controls the amount
of melanin
pigment produced, accounts for about 74 percent
of the total variation in people's eye color.
Of the darker - skin
gene variants, three appear to have evolved from less
pigmented variants.
The next step, he said, is to demonstrate the same results among those called protananamolous, who suffer from a less common form
of color blindness involving an overabundance
of red
pigment genes.
Humans have
genes that code for three different types
of visual
pigments, called opsins.
The
genes that affect hair colour also affect other cancer types, while other
pigment genes affect the chances
of having Crohn's and other forms
of bowel disease.
Researchers analyzed the genomes
of 16 related orange and white tigers in captivity, fully mapping those
of the three parent tigers to show that a mutation in one
pigment gene called SLC45A2 is at play — the very same
gene that drives lighter coloring in people
of European ancestry, chickens, and some mice.
The researchers are not yet sure how this happens; the mutated
gene may alter the production
of the
pigment, melanin, they report online today in Current Biology.
Researchers at the University
of California, Santa Barbara, and their colleagues inserted the
gene for this extra
pigment into the mouse X chromosome.
A small number
of known
genes, it is thought, account for nearly 50 percent
of pigment variation.
This
gene is involved in regulating production and storage
of melanin, the
pigment that determines hair, skin and eye color.
Many
of these
genes lie within the DNA segment that differs between carrion and hooded crows, suggesting that somehow the
pigment genes that give the two groups their unique appearance are also keeping the species separate.
Reasoning that the female version
of L - opsin might also do the trick for males, researchers from the University
of Washington used a harmless virus to carry the
pigment gene behind the monkeys» retinas.
«Evolutionary shifts from blue to red flowers in Penstemon predictably involves degeneration
of the same particular flower
pigment gene, suggesting there are limited genetic «options» for evolving red flowers in this group,» said Wessinger.
In these species, the
gene agouti controls the relative amount
of red and yellow
pigments in the skin, and melanocortin 1 receptor (Mc1r) does the same for black and brown.
Petal color for both flowers is heavily influenced by a
gene known as YUP, which permits or prevents the deposition
of yellow
pigments.
Now, researchers have discovered how the corals»
pigment genes control the range
of colors they can produce.
Using a slew
of molecular techniques, the team identified the color - stealing culprit in white grapes as a mobile fragment
of DNA, called a retrotransposon, which inserts itself into the
gene controlling
pigment production.
Previously, Shozo Kobayashi
of the National Institute
of Fruit Tree Science in Tsukuba, Japan, identified a specific
gene that controls the production
of this
pigment in black - skinned grapes.
About 10 %
of cases are due to a mutation in retinal
pigment epithelium 65 (RPE65), a
gene that codes for an enzyme that helps retinal cells make rhodopsin.
When activated by the relevant light colour, these
genes feed signals to other added
genes that then produce visible
pigment of an identical colour.
The
gene is involved in the production
of melanin, a
pigment that gives hair and skin their hues.
The flowers reminded Teeri, who has studied plant
pigments at the University
of Helsinki,
of blooms created in a landmark
gene - engineering experiment some 30 years earlier.
Through the systematic analysis
of ommochrome and porphyrin biosynthetic pathways, the authors identified several
genes required for producing planarian
pigment.
This could be due to incomplete
gene knockdown, the presence
of another body
pigment in analogy with the Drosophila eye, or accumulation
of colored intermediates in ommochrome biosynthesis (for instance, kynurenine imparts a yellow color to the eyes
of deep - sea fish; Thorpe et al., 1992).
The team discovered that visual
pigment genes have changed substantially during snake evolution, including many changes to the wavelengths
of light that the
pigments are sensitive to.
The team, which included Museum researchers Dr Bruno Simões and Filipa Sampaio, studied the
genes involved in producing these visual
pigments in 69 species
of snake.
Melanocytes respond by altering
gene transcription, and these changes in
gene expression profiles result in easily quantifiable phenotypes such as modified
pigment production (a hallmark
of melanocyte differentiation state) and changes in morphological cell properties.
The treatment could help people who have a fault in a
gene called RPE65, which causes problems in the retinal
pigment epithelium (RPE), a thin layer
of cells that support and nourish photoreceptors.
In the article, the researchers show that the white coat color in dogs is caused by mutations in the MITF
gene that is crucial for normal development
of pigment cells.
Potential projects include identifying common pathways that modify retinal degenerative disease from a large collection
of actively maintained mouse models; determining molecular networks implicated in pathological disruption
of the retinal
pigment epithelium; identifying molecular pathways that regulate postnatal ocular growth; and using mouse models to assess the pathogenic role
of gene variants that increase the risk
of age - related macular degeneration as identified by human genome - wide association studies.
Spectroscopy & Application
of Lasers, Zare / Moerner / +, 6 - 1 Nuclear Hormone Signaling, Chambon / Evans / Jensen, 6 - 1 Bioinorganic Chemistry, Gray / Lippard / Holm / — , 8 - 1 The Field (everything not listed), 10 - 1 Techniques in DNA Synthesis, Caruthers / Hood / +, 10 - 1 Electrochemistry / Electron Transfer, Bard / Hush / Gray / — , 19 - 1 Instrumentation / Techniques in Genomics, Venter / +, 19 - 1 Biological Membrane Vesicles, Rothman / Schekman / +, 19 - 1 Molecular Studies
of Gene Recognition, Ptashne, 19 - 1 Organic Electronics, Tang / +, 39 - 1 Polymer Science, Matyjaszewski / Langer / + / — 69 - 1 Solar Cells, Grätzel / +, 74 - 1 Mechanistic Enzymology, Walsh / Stubbe / Koshland / + / — , 74 - 1 Combinatorial Chemistry / DOS, Schreiber / +, 99 - 1
Pigments of Life, Battersby / +, 99 - 1 Development
of the Birth Control Pill, Djerassi, 99 - 1 Molecular Modeling and Assorted Applications, Karplus / Houk / Schleyer / Miller / + / — , 99 - 1 Applications
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These «deletions» shut down the
genes that normally kick off a cascade
of proteins, known as the anthocyanin pathway, which is supposed to produce red
pigment.
-- We have shown that the genetic change causing fibromelanosis is a complex rearrangement that leads to increased expression
of Endothelin 3, a
gene which is known for promoting the growth
of pigment cells, explains Ben Dorshorst the post-doctoral researcher responsible for the work.
Pigment genes could affect the chances
of having Crohn's or other bowel diseases.
The research published by GenoMEL has identified inherited
genes which increase melanoma risk which are
pigment genes (affecting skin colour and vulnerability to sunburn),
genes which are associated with having more moles (melanocytic naevi) and others associated with a part
of the genetic makeup
of the cell called the telomere.
A
gene called Alx3 blocks the differentiation
of pigment - producing cells in the skin
of the African striped mouse, thus generating the mouse's characteristic light - colored stripes, a new...
Recently, we demonstrated that anthocyanins, which are
pigments widespread in the plant kingdom, have the potency
of anti-obesity in mice and the enhancement adipocytokine secretion and adipocyte
gene expression in adipocytes.
Eating turmeric in a small quantity or taking it in a dietary supplement is believed to support healthier - looking skin, including for people with eczema, psoriasis, and acne.56) The curcuminoid
pigments in turmeric support
genes that enhance the body's synthesis
of antioxidants, protecting the skin and other organs from oxidative damage due to free radicals from environmental toxins or chronic stress.
Two
genes have been previously implicated in the loss
of pigment in Appaloosas.
The purpose
of this study is to 1) investigate the morphology
of the
pigment producing cells (melanocytes) and determine if any ultrastructural differences exist among varying appaloosa genotypes, and 2) examine previously associated
genes to determine the biological mechanism
of pigment loss.
Color is actually governed by several sets
of genes, some that produce the color itself, others that influence intensity, pattern, amount and distribution
of white markings, or distribution
of pigment on individual hairs.
«E», normal extension
of black, allows the A-series alleles to show through, and «e», recessive red / yellow, overrides whatever
gene is present at the A locus to produce a dog which shows only phaeomelanin
pigment in the coat.
This dog carries two copies
of KB which prevents expression
of the agouti
gene (A locus) and allows for solid eumelanin (black
pigment) production in
pigmented areas
of the dog.
The KB variant
of the CBD103
gene promotes eumelanin (black
pigment) synthesis by blocking agouti
gene expression at the A Locus which would otherwise inhibit MC1R production
of eumelanin.
The alternate ky variant
of the CBD103
gene disrupts the normal function
of the CBD103
gene allowing for agouti (A locus)
gene expression and the inhibition
of black
pigment synthesis.