Sentences with phrase «of plaque deposition»

WALTHAM ™ research has demonstrated that the QLF technique is sensitive, repeatable and reproducible in the assessment of plaque deposition in dogs [Wallis et al., 2016] and cats [Marshall - Jones et al., 2017].

Yong Ming Li and Dennis W. Dickson, «Enhanced binding of advanced glycation endproducts (AGE) by the ApoE4 isoform links the mechanism of plaque deposition in Alzheimer's disease,» Neuroscience Letters (1997), Volume 226, Issue 3, 155 - 158; doi: 10.1016 / S0304 - 3940 (97) 00266 - 8.

Not exact matches

Though the UPR usually promotes healthy endoplasmic reticulum function, sustained UPR activation sometimes results in diseases such as atherosclerosis, the deposition of fatty plaques on artery walls, among other conditions.

High levels of «good» cholesterol and low levels of «bad» cholesterol are correlated with lower levels of the amyloid plaque deposition in the brain that is a hallmark of Alzheimer's disease, in a pattern that mirrors the relationship between good and bad cholesterol in cardiovascular disease, UC Davis researchers have found.

In a group of animals in which tiny implanted windows allowed direct imaging of brain tissue, the progression of A-beta plaque deposition was fastest in animals receiving APOE4 and slowest, sometimes even appearing to regress, in mice injected with APOE2.

«This study has allowed us to sort out, in mice, which effects of the different types of APOE were most important to variation in amyloid plaque deposition,» says Eloise Hudry, PhD, of MGH - MIND, lead author of the Science Translational Medicine report.

The main hypothesis on the cause of Alzheimer's involves amyloid deposition, the buildup of plaques in the brain that impair neurological function; most biomedical efforts to tackle the disease have focused on this issue.

It is the condition where the arteries that supply blood to the heart muscle (coronary arteries) become narrowed due to a deposition of fatty material (plaque) in the walls of the arteries.

This is the proposal that deposition of amyloid - beta, a major protein ingredient of the plaques that accumulate in the brains of Alzheimerâ $ ™ s patients, is a central event in the pathology of the disease.

Dendritic Spine Density, Morphology, and Fibrillar Actin Content Surrounding Amyloid -[beta] Plaques in a Mouse Model of Amyloid -[beta] Deposition.

The early intraneuronal pathology was accompanied by a significant elevation of soluble Aβ42 peptides that paralleled the presence and progression of early cognitive deficits, several months prior to amyloid plaque deposition.

Alzheimer's disease (AD) is characterized by deposition of amyloid - β (Aβ) plaques and neurofibrillary tangles in the brain, accompanied by synaptic dysfunction and neurodegeneration.

However, it is widely accepted that before the overt deposition of amyloid plaques and neurofibrillary tangles, the accumulation of amyloid - β (Aβ) peptides is one of the first steps in the series of pathogenic changes that lead to neurodegeneration and dementia [5, 6].

This technique allowed the detection of C - terminally truncated peptides, including Aβ38, Aβ39, Aβ40 and Aβ42 species, as early as 3 months of age; a time point which precedes amyloid plaque deposition by several months (4 — 6 months).

Given the lack of definitive AD biomarkers in humans, transgenic animal models of the amyloid pathology continue to be valuable tools to examine molecular changes preceding the deposition of amyloid plaques and associated pathology (i.e. late inflammation, neuritic dystrophy, etc.).

These results support the amyloid cascade of tau phosphorylation in AD regarding phosphorylation of tau dependent on beta - amyloid deposition in neuritic plaques, but not of tau in neurofibrillary tangles and threads.

Immunizing transgenic PDAPP mice, which overexpress mutant APP and develop beta - amyloid deposition resembling plaques in Alzheimer's disease (AD), results in a decrease of amyloid burden when compared with non-treated transgenic animals.

BACKGROUND: AD is characterized by cerebral deposition of beta - amyloid plaques with amyloid beta - peptide (Abeta) 42 as the major peptide constituent, along with neurofibrillary tangles and neuronal loss.

Alzheimer's disease results from the deposition of amyloid plaques in the brain.

High Vitamin C supplementation reduces amyloid plaque deposition (cause of AD), blood brain barrier disruptions and mitochondrial dysfunction in the brains.

Their high fiber content also plays an important role in fighting deposition of plaque, mostly associated with development of arteriosclerosis.

Other studies have shown that dogs affected by this syndrome show deposition of amyloid (a protein) in their brains in patterns very similar to the amyloid plaques found in the brains of human Alzheimer's patients.

Other studies have shown that dogs affected by this syndrome show deposition of a protein called amyloid in their brains in patterns similar to the amyloid plaques found in the brains of humans with Alzheimer's disease.

The Veterinary Oral Health Council (VOHC) awards a Seal of Acceptance for products that successfully meet pre-set criteria for effectiveness in controlling plaque and / or calculus deposition in dogs and cats.

The Veterinary Oral Health Council (VOHC ¬ Æ) awards its Seal of Acceptance to products that successfully meet pre-set criteria for effectiveness in controlling plaque and tartar deposition in dogs and cats.

If you would like information on products that will help control deposition of dental plaque and tartar on the teeth of your pet, click Veterinary Oral Health Council.

If plaque is left undisturbed it can become hardened due to deposition of substances such as calcium in the plaque layer.

The teeth will be polished to discourage deposition of new plaque.

Maxi / Guard Oral Cleansing Wipes work effectively to cleanse the oral cavity of pets while controlling halitosis and reducing the deposition of plaque.

OraZn helps reduce the deposition of plaque, gingival inflammation and offensive mouth odors.

work effectively to cleanse the oral cavity of pets while controlling halitosis and reducing the deposition of plaque.