Autophagy plays a significant role in the maintenance
of plasma amino acid concentrations under starvation conditions.
Ellappan Babu, Yangzom Bhutia and Sabarish Ramachandran performed most of the experiments; Jaya Gnanaprakasam did the ELISA for cytokines; Puttur Prasad and Muthusamy Thangaraju were responsible for the design of the targeting vector used in the generation of the knockout mouse and also for the analysis
of plasma amino acids; Vadivel Ganapathy was responsible for the design of the study, interpretation of the data, and writing of the manuscript.
The paper «Glycemia and insulinemia in healthy subjects after lactose - equivalent meals of milk and other food proteins: the role
of plasma amino acids and incretins» sheds some light upon the mechanism of insulin secretion.
High levels
of these plasma amino acids predicted future diabetes, e.g., as found for single plasma amino acids, such as leucine, with an HR of 3.66 (95 % 1.61 — 8.29), and for combinations of the amino acids isoleucine, tyrosine, and phenylalanine, with an HR of 5.99 (2.34 — 15.34) comparing the highest versus lowest quartile (34).
This is in line with earlier experimental elevations
of plasma amino acids by infusion, which resulted in impaired insulin - stimulated glucose disposal and insulin - mediated suppression of (hepatic) glucose production (36,37).
Not exact matches
Effect
of Intake
of Different Dietary Protein Sources on
Plasma Amino Acid Profiles at Rest and After Exercise.
Plasma, erythrocyte human milk levels
of free
amino acids in lactating women administered aspartame or lactose.
Nutrients such as
amino acids (the building blocks
of proteins) and sugars and chemical signals such as hormones hitch a ride in the
plasma and are carried throughout the body.
Brain serotonin content is dependent on
plasma levels
of the essential
amino acid tryptophan.
We monitored the
plasma levels
of amino acids in wild - type and knockout mice and found no significant differences between the two genotypes (Table 1).
The review
of systemic
amino acid homeostasis will focus on organs and mechanisms that influence
plasma amino acid concentrations.
The
plasma amino acids were similar in wild - type and knockout mice and there were no major compensatory changes in the expression
of other
amino acid transporter mRNAs.
This will temporarily dilute blood
plasma concentrations
of leucine and other regulatory
amino acids, triggering autophagy to the point where the original equilibrium
of regulatory
amino acids is restored.
It is one
of the most abundant free
amino acids within
plasma and muscles and is required for rapid cell division.
Sugiyama K, Muramatsu K.J Significance
of the
amino acid composition
of dietary protein in the regulation
of plasma cholesterol.
Effect
of a test meal, without and with protein, on muscle and
plasma free
amino acids.
The rapid rise in
plasma amino acids may stimulate protein synthesis, but it also accelerates the rate
of amino acid breakdown and production
of urea.
Plasma amino acid patterns in hepatic encephalopathy
of differing etiology.
Korhonen M, Vanhatalo A, and Huhtanen P. Effect
of Protein Source on
Amino Acid Supply, Milk Production, and Metabolism
of Plasma Nutrients in Dairy Cows Fed Grass Silage.
Blomstrand, E., Hassmen, P., Ekblom, B., and Newsholme, E. A. Administration
of branched - chain
amino acids during sustained exercise — effects on performance and on
plasma concentration
of some
amino acids.
[11]- Sanchez A, Hubbard RW,
Plasma amino acids and the insulin / glucagon ratio as an explanation for the dietary protein modulation
of atherosclerosis, Med Hypothesis, 1991; 35:324 - 329.
Influence
of ingesting a solution
of branched - chain
amino acids on
plasma and muscle concentrations
of amino acids during prolonged submaximal exercise.
Blomstrand, E., Andersson, S., Hassmen, P., Ekblom, B., and Newsholme, E. A. Effect
of branched - chain
amino acid and carbohydrate supplementation on the exercise - induced change in
plasma and muscle concentration
of amino acids in human subjects.
Lastly casein protein has the slowest absorption rate but in doing so it elevates
plasma amino acid levels for the longest period
of time.
Thus, if you had eaten a meal with a considerable amount
of protein just an hour or two before working out, your
plasma amino acid levels (the levels in your blood) would be quite high come workout time.
Therefore should no additional carbohydrate be ingested during prolonged exercise, the task
of maintaining blood glucose levels rests firmly on the liver's glycogen stores and gluconeogenesis (the manufacturing
of glucose from
plasma amino acids).
Taurine is, says JN, the «most abundant free
amino acid in animal tissues [even though it] accounts for only 3 %
of the free
amino acid pool in
plasma, it accounts for 25 %, 50 %, 53 %, and 19 %, respectively,
of this pool in liver, kidney, muscle, and brain.»
These results concur with previous data indicating that only moderate insulin elevations (15 — 30 mU / L) are required to maximize net muscle protein balance in the presence
of elevated
plasma amino acids [96].
Recent data from animal models suggest that consumption
of BCAA's between meals can overcome the refractory response in protein synthesis that occurs when
plasma amino acids are elevated, yet protein synthesis is reduced [174].
Evidence
of the refractory phenomenon was shown by Bohé et al. [117], who elevated
plasma amino acid levels in humans and observed that MPS peaked at the 2 - hour mark, and rapidly declined thereafter despite continually elevated blood
amino acid levels.
These powerful emotions trigger adrenal hormone release — the physiological effects
of which include activation
of adipocyte lipase (resulting in mobilization
of free fatty
acids) and partial inhibition
of protein synthesis, i.e., the
plasma amino acids which are normally (readily) utilized by nonmalignant cells for protein synthesis are only partially used resulting in an increase in the availability
of amino acids to meet tumor cell metabolic needs.
(a) The oxidative catabolism
of free fatty
acids and
amino acids (via the Respiratory Chain and Citric
Acid Cycle) might be inhibited in hypoxic cancer cells via the judicious use of agents which inhibit their availability, i.e., partially inhibit hepatic fatty acid synthesis and keep plasma amino acid levels within the normal range, thus decreasing ATP product
Acid Cycle) might be inhibited in hypoxic cancer cells via the judicious use
of agents which inhibit their availability, i.e., partially inhibit hepatic fatty
acid synthesis and keep plasma amino acid levels within the normal range, thus decreasing ATP product
acid synthesis and keep
plasma amino acid levels within the normal range, thus decreasing ATP product
acid levels within the normal range, thus decreasing ATP production;
Keep
plasma amino acid levels within the range required to sustain general health [Normal cells will rapidly utilize the
amino acids liberated by the catabolism
of foods.
When cortisol is released, it causes a breakdown
of protein, carbohydrate, and fat and an increase in
plasma amino acids, specifically glutamine and the branched - chain
amino acids (BCAAs).
Plasma amino acid response after ingestion
of different whey protein fractions.
ΣIAA, sum
of measured
plasma indispensable
amino acid concentrations.