Sentences with phrase «of preclinical research»

Melatonin has roles in cancer prevention, strengthening your immune system, and may even slow down cellular aging; in fact, it has been the subject of preclinical research on over 100 different disease applications.1 It's your body's «Superhero of the Night,» and light is his number one nemesis.

Laboratory of Preclinical Research of a Higher Standard.

Thus, to support and enhance our collaborations with industry partners dedicated to improving the lives of children with nervous system disorders, the Translational Neuroscience Center (TNC) at Boston Children's Hospital has recruited Robin Kleiman, PhD, as the head of preclinical research.

Abstract Co-head Cancer and Neurosciences axis Northwest canceropole, Cancer and cognition platform; ICCTF member (editing of preclinical research guidelines).

The current study is built on more than 20 years of preclinical research on memory codes led by Sam Deadwyler, Ph.D., professor of physiology and pharmacology at Wake Forest Baptist, along with Hampson, Berger and Song.

Around half of all preclinical research in the United States is not reproducible (SN: 1/24/15, p. 20).

Dr. Michael Kilgard, associate director of the Texas Biomedical Device Center (TxBDC) and Margaret Forde Jonsson Professor of Neuroscience in the School of Behavioral and Brain Sciences, led the research team with Dr. Seth Hays, the TxBDC director of preclinical research and assistant professor of bioengineering in the Erik Jonsson School of Engineering and Computer Science, and postdoctoral researcher Eric Meyers PhD» 17.

«Improving the design, conduct, and reporting of preclinical research is of the utmost priority if we are to move ahead, with all due haste, in the development of novel treatments across a range of diseases.»

• Changes may be afoot for biomedical scientists as a result of efforts at the National Institutes of Health (NIH) to improve the reproducibility of preclinical research.

Targacept needs to succeed in only two of its phase III trials to gain approval, says Merouane Bencherif, head of preclinical research at the company.

Not exact matches

Looking at sixty - seven recent drug discovery projects based on preclinical cancer biology research, they found that in more than 75 percent of cases the published data did not match up with their in - house attempts to replicate.

Preclinical and clinical research demonstrates that repeated substance exposure leads to molecular and functional neuroplastic brain changes that powerfully contribute to the vicious cycle of use.

Through a rigorous pharmaceutical approach, Gnosis carries out a seamless flow of operations, from product concept to research and development, preclinical and clinical studies, regulatory filing and Intellectual properties, manufacturing and distribution standing alongside customers.

«In 2015 our research team showed that blocking a different protein in the NOD2 pathway could halt inflammation, and was able to halt the progression of multiple sclerosis in a preclinical model.

«It performed so well in the preclinical model, we determined that to boost its effects further was essentially impossible,» said Orme, also a co-founder of CSU's Mycobacteria Research Laboratories.

In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS ONE from the Perelman School of Medicine at the University of Pennsylvania.

This discovery is a result of research on the effects of ONA on a preclinical model of epithelial ovarian cancer (EOC) both in vivo and in vitro.

The researchers reprogrammed the cells to create induced pluripotent stem cells in an FDA - compliant facility at the Broad Stem Cell Research Center; the use of this facility is an important step in the process as preclinical research moves toward human clinicalResearch Center; the use of this facility is an important step in the process as preclinical research moves toward human clinicalresearch moves toward human clinical trials.

For example, Matt Krause, director of human resources at CV Therapeutics, says, «Our research programs include multiple, cutting - edge cardiovascular product candidates in various stages of clinical trials and preclinical programs, all of which rely heavily on the contributions from our many B.S. - and M.S. - level scientists.»

Next, the research team will examine specifically whether these liver cells obtained from human embryonic stem cells in a dish help repair injured livers in preclinical animal models of liver disease.

The attendees agreed on a common set of Principles and Guidelines in Reporting Preclinical Research (www.nih.gov/about/reporting-preclinical-research.htm) that list proposed journal policies and author reporting requirements to promote transparency and reproducibility.

An editorial in the same issue of the journal notes that drug - based treatments for liver cancer are limited and that the UT Southwestern study showed «truly remarkable results that should prompt further research under preclinical settings, given its potential to lead to a paradigm shift in treatment.»

«To better understand safety issues, we are making efforts to employ more modern investigational, molecular approaches to safety assessment — and increase our safety testing work force by about 10 percent,» says Phil Bentley, vice president and global head of preclinical safety at Novartis Institutes for BioMedical Research in New York City.

His research efforts are divided between preclinical models, the development, performance, and monitoring of cancer immunotherapy trials and the training of the next generation of translational investigators.

Research in recent years has covered both preclinical basic research and the transfer of the results generated from studies of mouse models to clinically applicable techniques for treating female infeResearch in recent years has covered both preclinical basic research and the transfer of the results generated from studies of mouse models to clinically applicable techniques for treating female inferesearch and the transfer of the results generated from studies of mouse models to clinically applicable techniques for treating female infertility.

Small - animal imaging has become an important research tool for preclinical studies of infectious diseases, according to senior author Thomas M. Bocan, Ph.D., of the U.S. Army Medical Research Institute of Infectious Diseases (USresearch tool for preclinical studies of infectious diseases, according to senior author Thomas M. Bocan, Ph.D., of the U.S. Army Medical Research Institute of Infectious Diseases (USResearch Institute of Infectious Diseases (USAMRIID).

In a paper published in Advanced Functional Materials, the research team reports on the new material's key properties, many of which can be finely tuned, and on the results of using the material in preclinical models of wound healing.

Recently published in the journal eLife and featured in a poster session at this year's American Association for Cancer Research (AACR) annual meeting, preclinical experiments show for the first time that PLK1 promotes the migration of prostate cancer cells by setting in motion a process that induces what is known as the epithelial - to - mesenchymal transition (EMT).

The Walter Reed Army Institute of Research (WRAIR) and collaborators at the Beth Israel Deaconess Medical Center and Harvard Medical School have completed a promising preclinical study of two Zika vaccine candidates that suggests that an effective human vaccine will be achievable.

Translational research, which applies findings to a health care setting, accounted for 33.3 per cent of this spend, compared with 1997 - 2010 when funding was almost entirely preclinical.

Scientists at the University of California at San Diego currently are studying MW108 in preclinical cancer immunology research.

«The pace of preclinical and early clinical development for Zika vaccines is unprecedented,» said Barouch, corresponding author and director of the Center for Virology and Vaccine Research at BIDMC.

According to the authors of the study, in future researches it will be necessary to know about the action mechanism of the new products - highly selective and with low cell toxicity on in vitro tests - and broaden preclinical studies with laboratory animal models.

Since eye and vision research can be conducted noninvasively, advancement of trials from the preclinical to the clinical phase could be relatively fast.

«We are at a point in our research where we have validated the efficacy of this combination treatment approach in preclinical animal models, and we now need to define its safety through toxicology and pharmacology studies,» says Fisher, Thelma Newmeyer Corman Endowed Chair in Cancer Research and co-leader of the Cancer Molecular Genetics research program at VCU Massey, chairman of VCU School of Medicine's Department of Human and Molecular Genetics and director of the VCU Institute of Molecular Mresearch where we have validated the efficacy of this combination treatment approach in preclinical animal models, and we now need to define its safety through toxicology and pharmacology studies,» says Fisher, Thelma Newmeyer Corman Endowed Chair in Cancer Research and co-leader of the Cancer Molecular Genetics research program at VCU Massey, chairman of VCU School of Medicine's Department of Human and Molecular Genetics and director of the VCU Institute of Molecular MResearch and co-leader of the Cancer Molecular Genetics research program at VCU Massey, chairman of VCU School of Medicine's Department of Human and Molecular Genetics and director of the VCU Institute of Molecular Mresearch program at VCU Massey, chairman of VCU School of Medicine's Department of Human and Molecular Genetics and director of the VCU Institute of Molecular Medicine.

Until now, those programs were managed by the National Human Genome Research Institute (NHGRI) under the direction of Christopher Austin; he will serve as director of the NCATS preclinical division.

Patrick McConville, Ph.D., is chief operating officer, chief scientific officer, and a co-founder of Molecular Imaging Inc., the only contract research organization (CRO) dedicated to in vivo preclinical imaging.

«One of the biggest barriers in the field of adrenocortical carcinoma research has been lack of a preclinical model.

The aim of the project is two-fold: to provide evidence about reproducibility in preclinical cancer research, and to identify the factors that influence reproducibility more generally.

E. Intensify research on the major drivers of childhood cancers Improve our understanding of fusion oncoproteins in pediatric cancer and use new preclinical models to develop inhibitors that target them.

Explore our specialized research portfolio of unique solutions to clinical and preclinical research problems developed by experts at Wake Forest Baptist Medical Center.

PHILADELPHIA --(July 11, 2017)-- Researchers at The Wistar Institute, an international leader in biomedical research in the fields of cancer, immunology and infectious diseases, with collaborators at Indiana University Melvin and Bren Simon Cancer Center and Syndax Pharmaceuticals, Inc., (Nasdaq: SNDX) announce the results of a preclinical study demonstrating that entinostat, Syndax's oral, Class - I histone deacetylase inhibitor, enhances the antitumor effect of PD - 1 (programmed death receptor - 1) blockade through the inhibition of myeloid derived suppressor cells (MDSCs).

IDMIT is an infrastructure for preclinical research in infectious diseases and immunology which is certified ISO9001 and which includes 1) A large animal facility with capacity to host NHP in BSL2 and BSL3 containment, 2) State - of - the - art laboratories for cell biology, immunology, molecular biology, flow cytometry and mass cytometry (CyTof), cell - sorting and confocal microscopy in BSL3 containment; 3) A biological resources centre with high storage capacity; 4) Highly innovative technologies for in vivo imaging of large animals in BSL2 and BSL3 containment, including a two - photon microscope, a PET - CT facility, and several optic based technologies (fibered endo - microscopy, near infra - red imaging).

Members of the Philadelphia Research Consortium have made a pledge to the startup and biotech community to use a universal, sponsored research agreement with all potential partners interested in exploring preclinical discovery research with participating institutions in order to facilitate meaningful collaboResearch Consortium have made a pledge to the startup and biotech community to use a universal, sponsored research agreement with all potential partners interested in exploring preclinical discovery research with participating institutions in order to facilitate meaningful collaboresearch agreement with all potential partners interested in exploring preclinical discovery research with participating institutions in order to facilitate meaningful collaboresearch with participating institutions in order to facilitate meaningful collaborations.

Finally, the wide diffusion of some of these diagnostic techniques in the clinical practice, such as MR, US and CT, makes these tools a valuable translation bridge between preclinical research and clinical trials.

Janssen GPH will also prioritise work with the International Partnership for Microbicides developing the investigational drug dapivirine for use as a monthly vaginal microbicidal ring designed to prevent sexual transmission of HIV and continue its pact with Drugs for Neglected Diseases initiative for the preclinical research of a reformulated form of flubendazole for lymphatic filariasis (elephantiasis) and onchocerciasis (river blindness), Janssen GPH is also developing a new, chewable formulation of Vermox (mebendazole) that will facilitate treatment of intestinal worms in younger children.

Katherine W. Klinger, PhD, Senior Vice President for Genetics and Genomics at the Genzyme Corporation, and Assistant Clinical Professor in the Department of Pediatrics at the University of Connecticut School of Medicine suggested that for an orphan disease it may be necessary to use multiple animal models in the preclinical research stage, because one animal model may not fully recapitulate the human disease.

PNP Therapeutics, Inc. — a company based on a gene - therapy technology developed by scientists at Southern Research Institute and the University of Alabama at Birmingham (UAB)-- has found an approach that has abolished otherwise unmanageable human cancers in preclinical rodent studies.

Seres Therapeutics, Inc. (NASDAQ: MCRB) today announced that new preclinical data supporting the development of microbiome therapeutics for immuno - oncology (leveraging gut microbiota to impact tumor immunotherapy) 1 will be presented today by Sceneay et al in the late breaking poster session at the 2018 American Association for Cancer Research Annual Meeting (AACR) in Chicago.

Nanotheraputics for Antibiotic Resistent Emerging Bacterial pathogens (NAREB) European Research Infrastructures for Poverty Related Diseases (EURIPED) Biomarkers for enhanced vaccines immunosafety (BioVacSafe) European network of vaccine research and development TRANSVAC Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development (TBResearch Infrastructures for Poverty Related Diseases (EURIPED) Biomarkers for enhanced vaccines immunosafety (BioVacSafe) European network of vaccine research and development TRANSVAC Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development (TBresearch and development TRANSVAC Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development (TBVAC2020)