Sentences with phrase «of preclinical work»

Your experience reminds me of preclinical work.

Not exact matches

Some retrospective studies and preclinical work have indicated that it might also lower a person's risk of cancer, though at least one clinical trial wasn't able to show that it had any protective effect on esophageal cancer.

The first move sets Takeda up to work on development of FIN - 524, a preclinical therapy that contains cultured bacteria strains and which could theoretically be used to treat gut diseases.

«Although this is preclinical work, the strategy warrants further investigation because it holds promise as a simple, economical way to overcome the major limitation of current flu vaccination strategies and may provide broad protection against seasonal and pandemic influenza,» added Elliott.

«What we discovered in our preclinical work is evidence of how groups of neurons coordinate and cooperate with each other in a very particular way that gives us deeper insight into how the brain is controlling the arm,» Shenoy said.

«Even though they're inactivating the virus, it's still there,» says Ross, whose laboratory worked with Novavax during its preclinical studies, when the start - up was in need of laboratory facilities.

«She had worked at Immunex's law department, was one of the co-discoverers of Enbrel and was listed on multiple original Immunex patents, and had been involved in preclinical work on compound discovery,» says Ruth Kunath, who managed Vulcan's biotech portfolio from 1992 to 2003 and hired Beckmann.

In the University of Toronto MD / PhD Program, the majority of students complete the preclinical courses of medical school (i.e., the first year and a half) and then pursues full - time graduate work, completes the PhD, and only then returns to medical school to complete the clinical component.

«To better understand safety issues, we are making efforts to employ more modern investigational, molecular approaches to safety assessment — and increase our safety testing work force by about 10 percent,» says Phil Bentley, vice president and global head of preclinical safety at Novartis Institutes for BioMedical Research in New York City.

The group plans to continue exploring the mechanics of SF3B1 while also pushing forward with the preclinical work needed to form the rational basis for targeting this gene in patients with advanced mucosal melanoma.

Overall, this work illustrates that better understanding the basic biology of the immune system in preclinical models may open up a window for the development of novel treatments for human autoimmune disease.

The study, which lays the foundation for future preclinical work, appears June 14 in Stem Cell Reports, a publication of the International Society for Stem Cell Researchers.

Russell Kern, chief scientific officer of the International Stem Cell Corporation in Carlsbad, California, which is providing the cells for and managing the Australian trial, says that in preclinical work, 97 % of them became dopamine - releasing cells.

If you had to pick an area of the brain that you can fix, the memory area is the most obvious because motor - task memory is really pretty well - worked out in preclinical models.

Hua's extensive work in Krainer's lab, in collaboration with Ionis, led to the identification and preclinical development of nusinersen, a snippet of modified RNA called an antisense oligonucleotide that intervenes in the splicing process to ensure that SMN2 expresses the full - length SMN protein.

Janssen GPH will also prioritise work with the International Partnership for Microbicides developing the investigational drug dapivirine for use as a monthly vaginal microbicidal ring designed to prevent sexual transmission of HIV and continue its pact with Drugs for Neglected Diseases initiative for the preclinical research of a reformulated form of flubendazole for lymphatic filariasis (elephantiasis) and onchocerciasis (river blindness), Janssen GPH is also developing a new, chewable formulation of Vermox (mebendazole) that will facilitate treatment of intestinal worms in younger children.

And there are a lot of treatments, or let's say potential treatments, that are working wonderfully in preclinical models that are ready to make the leap to human testing, and some of these have begun to make that transition to bridge from the laboratory to human - patient testing.

A major asset of the OMC platform is the tight integration of preclinical scientists with physicians, who work side by side to comparatively assess pathogenic, diagnostic and therapeutic issues raised in patients with the mouse model counterpart.

Faulty mitochondria contribute to a range of diseases and a research group working towards the use of mitochondrial donation techniques for women at risk of passing on those diseases to their children have described their preclinical work in the journal Nature.

The $ 1 million grant will be used for preclinical trial work with the goal of submitting an Investigational New Drug application to the FDA to begin clinical trials.

Our group is specifically working on improvement of islet isolation and transplantation protocols in clinical practice and the development of novel therapeutic options in the field of beta cell replacement with a clear translational «bench to bedside» approach by linking experimental research with preclinical and clinical work:

But while substantial data (including AFFiRiS» [15] and Prothena's [20,22] preclinical work) give good reason to think that early clearance of AS neuropathology will decelerate the rate of SN DA neuronal loss, astrocytosis, and possibly accumulation of senescent glial cells in PD, there is no reason to think that doing so will prevent these phenomena entirely, if for no other reason than because many other factors also contribute to their occurrence.

«The preclinical work being done by the McDonald lab has been extremely informative in helping us understand that Pexa - Vec is working like a vaccine to sensitize the immune system to attack cancer,» said James Burke, CMO of SillaJen Biotherapeutics.

Jörg has a proven ability of managing small companies, directing preclinical drug research and discovery, external collaborations and working in multinational environments in the biotech and pharmaceutical industry.

Our researcher received a proof - of - concept grant from the Washington Life Sciences Discovery Fund, and worked with Washington State University and Malignext to conduct preclinical trials that produced results that will be helpful in future preclinical and clinical trials.

«We are excited to support the preclinical and clinical development work with the PEC - Direct product candidate, given its potential to help the type 1 diabetes patients with the most urgent medical need, those at high risk of life - threatening acute complications.

His work has led to the development of two potential malaria vaccines, one of which is in clinical trials in the US and the other in preclinical development.

BACKGROUND Despite widely reported clinical and preclinical studies of rapid antidepressant actions of glutamate N - methyl - D - aspartate (NMDA) receptor antagonists, there has been very little work

The lab is currently a part of a multi-institutional group working on developing a prophylactic HIV vaccine under a five year Integrated Preclinical / Clinical AIDS Vaccine Development Program grant from the National Institutes of Allergy and Infectious Disease (NIAID).

This preclinical work led to the development of a novel anti-androgen ARN - 509, a small - molecule inhibitor discovered in collaboration with UCLA chemist Michael Jung, which targets the increased levels of androgen receptor found in hormone - refractory disease.

Now, three papers published concurrently in Science have shown CRISPR can treat a genetic disease in a postnatal mouse model, an important proof of concept for future preclinical and clinical work.

Dr. Lui has seven years of experience working in preclinical drug development and target validation in academia and industry.

New UC developments will contribute to the three categories of research CIRM hopes to establish: basic stem cell research and discovery, preclinical and clinical research, and preclinical development; centers of excellence which will work with any duel combination of stem cell discovery, clinical research and preclinical development; and special programs which will work with specialized research programs.

The Delaney Collaboratory to Cure HIV - 1 Infection by Combination Immunotherapy (BEAT - HIV Collaboratory) is a consortium of more than 30 top HIV researchers from leading academic research institutions working with government, nonprofit organizations, and industry partners to test combinations of several novel immunotherapies under new preclinical research and clinical trials.

Thank you for sending your work entitled «Mechanism and Preclinical Prevention of Increased Breast Cancer Risk Caused by Pregnancy» for consideration at eLife.

The past century has unveiled a plethora of preclinical data that has suggested the potential of a ketogenic diet as an aid in cancer treatment.7, 8 The benefits of a ketogenic diet, and dietary manipulation in general, may be a potent adjunct to current cancer treatments by synergistically working with chemotherapy and radiation therapy to starve cancer cells, leaving them more susceptible to damage from these treatments.7 - 10

AGTC plans to use the net proceeds of the offering to fund preclinical investigation and Phase 1/2 trials of potential product candidates for treatment of wet AMD; to expand its manufacturing capabilities and create a pilot manufacturing group; to in - license, acquire or invest in complementary gene therapy, technologies, products or assets; and for working capital and other general corporate purposes.

About Blog Helps you in every step of your research: publication of your work, preclinical development, preparation of regulatory documents.

Work experiences listed on sample resumes of Planning Managers include skills like providing recommendations regarding market potential for new targets including, but not limited to, indication prioritization and fast - to - market strategies, and providing commercial analysis in order to gain partnering opportunities for preclinical stage compounds.