Sentences with phrase «of prior therapies»

The median age of the patients is 61 and all are heavily pretreated — the median number of prior therapies was 6.3.

The median number of prior therapies for these patients was three; all the patients had been treated previously with at least one other EGFR TKI therapy, and most patients receiving chemotherapy as well.

Not exact matches

Prior to Human Longevity, Collins was the CEO and general manager of GE Healthcare's cell therapy division for three years.

Prior to being elected, Selina had a home - based family therapy practice, was the Director of Development for SHARE Family and Community Services and was a Counselling Instructor and Program Developer at the University of British Columbia's Life and Learning Centre and Vancouver Community College.

Appropriate care for the previous generation involves, among other things, what family therapist Murray Bowen has called «differentiation of the self from the family of origin» (see Family Therapy and Clinical Practice [Aronson, 19781) Those who work professionally with families have found that people experiencing marital or other family pain frequently have an unfinished agenda with the prior generation.

Dwyane Wade told the Associated Press that his left knee, injured in a collision with Spurs guard Manu Ginobili a game prior, required a draining of fluid and nearly eight hours of therapy heading into Game 7 of the NBA Finals.

Prior to becoming involved in politics, Charlotte was the CEO of Big White Wall, a socially responsible business spearheading the provision of mental health therapies online.

«For patients who have not responded to prior therapies, this drug now provides a very real chance to shrink their tumors and the hope of a lasting response to treatment.»

Beginning in 2009, they used functional magnetic resonance imaging (fMRI) to scan the brains of patients prior to treatment for depression; they then followed the patients through the course of therapy, generally for four weeks.

Dr. Glen Weiss, M.D., M.B.A., is the first author of the study abstract: Phase Ib / II Study of Pembrolizumab plus Chemotherapy in Advanced Cancer: Results of lung cancer patients receiving (at least) 1 prior line of therapy.

In past imaging studies, my colleagues and I noticed that cervical tumors that took up a lot of glucose prior to radiation treatment tended to be more resistant to radiation therapy than other tumors.

Prior studies have looked at the usefulness of laboratory monitoring during isotretinoin therapy.

«Considering that no prior research has conclusively demonstrated benefit of corticosteroid therapy for any manifestation of Lyme disease, including neurologic, rheumatologic or cardiac manifestations, we urge strong caution in prescribing corticosteroids in cases where facial paralysis is clearly the result of acute Lyme disease until better evidence is available,» said Dr. Jowett.

The ability to identify those patients unlikely to respond to first - line biologic anti-TNF therapies prior to their treatment would allow these patients to be prescribed alternative therapies, providing faster relief of symptoms and reducing the risk of future complications.

More than a third had received at least six prior lines of therapy without lasting success.

Hormone therapy was associated with a net decrease of 0.3 — 0.4 QALYs in men with a prior history of heart attack.

Specifically, long term follow up of a randomized clinical trial that compared ADT and radiation therapy (RT) to RT alone finds that men with significant comorbidity; most commonly prior heart attack, who received ADT died earlier, due to a fatal heart attack, compared to men who did not receive ADT.

Results of a comprehensive cost - effectiveness analysis suggest that patients who have RA and no contraindications to triple therapy should use it prior to a biologic as the next regimen.

In its first clinical trial, a breakthrough antibody therapy produced at least partial remissions in a third of patients with multiple myeloma who had exhausted multiple prior treatments, investigators at Dana - Farber Cancer Institute and other organizations report today online in the New England Journal of Medicine.

The new study involved 72 patients, all of whom had received at least two prior lines of therapy and whose disease had relapsed and no longer responded to treatment.

The ICD Registry identifies an opportunity for the use of medical therapy for patients with prior myocardial infarction or left ventricular systolic dysfunction; nearly 25 percent of ICD patients did not receive optimal medical therapy with ACE inhibitors and / or beta blockers at discharge.

The effect of the GS - DProSw molecule can be «switched off» by ultraviolet light prior to therapy.

Prior to this these interfaces were thought of as potential assistive technologies, not as therapies.

Lock, who has conducted several prior studies of the therapy that teaches parents to help their children eat normally again, said he thinks this approach works by interrupting the patient's behaviors that are supporting erroneous thinking patterns.

The manufacturer did not submit any studies for pretreated patients in which the comparator therapies were notably adapted to the results of the prior treatment.

The way forward for fracture prevention involves not only the development of better therapies to prevent fracture and easier delivery systems but also improved adoption of existing osteoporosis therapies for patients with prior fractures and minimization of adverse effects, particularly those associated with long - term use.»

The research team developed a new method called highly multiplexed single - nucleus sequencing (HM - SNS) to investigate CNA's clonal substructure and evolution in a cohort of 12 TNBC patients, whose tumors had been surgically removed prior to further therapy.

IGRT is the process of using frequent imaging, typically performed in the treatment room prior to radiation delivery, throughout a patient's course of radiation therapy treatment to improve localization of the target and normal structures, which allows for more precise and accurate radiation delivery.

Prof Soria will say: «Re-sensitisation to TKI can not account for the majority of these responses, since most patients had come off TKI as their immediate prior therapy.»

Prior to the WHI, the accepted view among physicians was that estrogen therapy reduced a woman's risk of developing cognitive impairment.

«The unusual genetic instability of GEA tumors enables them to evolve and diversify even prior to receiving therapy.

Importantly, without any prior knowledge from the analysis of tumor tissue, 76 % of «actionable» mutations (genetic changes that can be matched to an approved targeted therapy or one being tested in clinical trials) detected in tissue were also detected in blood.

In the early stages of dementia, recognising early life trauma may enable patients to access psychological therapy prior to significant cognitive decline.

«Given that education in transgender care was significantly associated with greater likelihood of prescribing hormone therapy and that prior research shows that additional medical instruction on transgender care contributes to greater competency, it will be vital to augment the training of military physicians to ensure skill and sensitivity in treating patients with GD,» the research letter concludes.

All patients who responded received only one prior line of chemotherapy therapy, suggesting that the drug may be an option earlier in the treatment course.

Patients who already practiced yoga on their own were not eligible for the study, nor were patients with a history of prior radiation therapy or those with metastatic disease.

Only ten of the 56 Trusts were able to report how many people received psychological therapy prior to ECT in compliance with government guidelines.

Although the patient's residual colonic microbiota, prior to therapy was deficient in members of the bacterial divisions - Firmicutes and Bacteriodetes, transplantation had a dramatic impact on the composition of the patient's gut microbiota.

A class of oral specialty drugs, tyrosine kinase inhibitors (TKIs), has revolutionized the treatment of CML, largely transforming it into a chronic condition and enabling many patients to have a near - normal lifespan, particularly when compared to a median survival of less than three years with prior therapies.

Multiple myeloma patients got some good news on November 16 — the immunotherapy daratumumab (Darzalex ®) was given approval by the FDA for the treatment of patients with multiple myeloma who have received at least three prior lines of therapy.

A Randomized Phase 2 Trial of Cediranib and Olaparib Compared to Bevacizumab in Patients with Recurrent Glioblastoma who have not received Prior VEGF Therapy

A Phase II Single - Arm Trial to Investigate Tepotinib in advanced (Stage IIIB / IV) Non-Small Cell Lung Cancer with MET Exon 14 (METex14) Skipping Alterations After Failure of at Least One Prior Active Therapy, Including a Platinum - Doublet - Containing Regimen

• Subject has received prior treatment with ASP2215 or other FLT3 inhibitors (with the exception of sorafenib and midostaurin used in first - line therapy regimen as part of induction, consolidation, and / or maintenance).

Previous history of myocardial infarction within 1 year prior to study entry, uncontrolled hypertension or uncontrolled arrhythmias • Pulmonary disease (e.g. COPD, asthma, etc) that is not controlled (moderate to severe symptoms) with current medication • Active, uncontrolled bacterial, viral, or fungal infections, requiring systemic therapy

The FDA approved Opdivo ® (nivolumab) for the treatment of patients with metastatic squamous non-small cell lung cancer (NSCLC) after prior therapy.

If not clinically feasible, discussion with Sponsor is required • The first dose of atezolizumab in the crossover arm should be within 42 days of last dose but no less than 21 days from the last dose prior to crossing over Exclusion Criteria: • Received any of the following prescribed medications or therapies in the past: 1.

The FDA has approved the CAR T - cell therapy axicabtagene ciloleucel (Yescarta) for the treatment of large B - cell lymphomas in adults who have failed or relapsed after two or more prior treatments.

All of the patients had received rituximab single - agent therapy previously for a median of six doses, 21 % had had prior rituximab maintenance therapy and 69 % had prior chemotherapy or chemoimmunotherapy.

Shah highlighted a study conducted at Memorial Sloan Kettering Cancer Center (MSKCC), which was a transplant vs no - transplant analysis of 19 patients with morphologic disease prior to CAR - T therapy.

«Although prior series have suggested that administering immune therapy to patients with autoimmune disease may be feasible, doing so conveys risk of disease exacerbation and requires careful monitoring.»