Sentences with phrase «of protein trafficking»

2004 — Natasha Raikhel — for her studies of protein trafficking and for developing the model plant Arabidopsis thaliana as the organism of choice for plant cell biology

Pathways and mechanisms of protein trafficking in polarized epithelia; Wilson and Menkes Diseases; copper ATPases

Selective imaging by correlated optical and electron microscopy of protein molecules of known ages will clarify fundamental processes of protein trafficking in situ.

Not exact matches

The meal options I came up with had to be: # 1 things that would be fairly easy to prepare (I wasn't about to take an extra hour on Sunday to make something elaborate), # 2 had to be foods I could easily manipulate the nutritional profile for (ensuring a balance of protein, carbs, and fat), # 3 the food had to store well in the fridge or freezer, # 4 they had to reheat well in either the toaster or microwave OR be eaten cold right from the fridge, and # 5 ideally, they needed to be things she could easily eat in the car on the way to school (remember, it takes us at least 20 minutes with no traffic to get to school so eating in the car gives us even MORE time to sleep lol).

There is significant opportunity in improving protein quality on - premise in terms of increasing traffic, brand equity, purchase intent and willingness to pay more per item, as well as reversing restaurant avoidance due to negative protein quality perceptions

The observation that loss - of - function mutations in DENND5A causes epileptic encephalopathy suggests that DENND5A protein controls membrane trafficking pathways critical for normal neuronal development and strengthens the argument that protein trafficking processes in cells are critical for normal neuronal development and function.

Protein trafficking from the endoplasmic reticulum (ER) to the Golgi apparatus involves specific uptake into coat protein complex II (COPII)-- coated vesicles of secretory and of vesicle targeting (v - SNARE) prProtein trafficking from the endoplasmic reticulum (ER) to the Golgi apparatus involves specific uptake into coat protein complex II (COPII)-- coated vesicles of secretory and of vesicle targeting (v - SNARE) prprotein complex II (COPII)-- coated vesicles of secretory and of vesicle targeting (v - SNARE) proteins.

Previous research conducted at Mount Sinai found that the trafficking of protein molecules between the nucleus (the cellular compartment containing the genetic information of the cell) and the cytoplasm is altered in neurodegenerative disease.

The new study revealed the Ebola VP40 protein assumes different structures to perform multiple roles in the virus's life cycle — membrane trafficking, virus assembly and control of replication.

Stella M. Hurtley Senior Editor Education: B.A., University of Cambridge; Ph.D., European Molecular Biology Laboratory, Heidelberg Areas of responsibility: Cell biology, cellular microbiology, membrane traffic, protein targeting, protein folding, organelle biogenesis, cytoskeleton, cell polarity, prion biology E-Mail: [email protected]

A protein that transports the simple chemical choline plays a major role in vesicle trafficking, ion homeostasis, and growth and development in plants, according to two new studies publishing 28 December in the open - access journal PLOS Biology, by Dai - Yin Chao of the Shanghai Institutes for Biological Sciences, China, and Sheng Luan of the University of California, Berkeley, USA, and co-workers.

CTL1 is also found in animal cells, Chao noted, and thus the study concluded that «characterizing CTL1 as a new regulator of protein sorting may enable researchers to understand not only ion homeostasis in plants but vesicle trafficking in general.»

Excitingly, these proteins are functionally enriched for membrane bending, vesicular biogenesis, and trafficking activities, suggesting that eukaryotes evolved from an archaeal host that contained some key components that governed the emergence of eukaryotic cellular complexity after endosymbiosis.

Pores, composed of many different proteins, the nucleoporins, cross the nuclear envelope and monitor the heavy traffic of the molecules, which takes place between the nucleus and the cytoplasm of the cell.

Additionally, Bardet - Biedl syndrome is a metabolic disease in which trafficking of proteins within the cilium is blocked.

That might seem like a run - of - the - mill molecular traffic violation, but it results in an entirely different protein than the one encoded by DNA — a clear violation of the central dogma.

Then, the research group examined the molecular mechanism behind the impaired synaptic functions and behaviors in ARHGAP33 KO mice and found that ARHGAP33 is localized to the Golgi apparatus to regulate intracellular protein trafficking of the Tropomyosin receptor kinase B (TrkB) receptor, a neurotrophin receptor, to synaptic sites.

The group» finding that the impaired intracellular protein trafficking leads to neuropsychiatric disorders - related abnormal higher brain functions has high impact on the fields of psychiatry, basic medical sciences, and pharmaceutical sciences.

In a paper published in the Journal of Neuroscience, the OIST Cell Signal Unit, led by Professor Tadashi Yamamoto, reported that mice lacking an intracellular trafficking protein called LMTK3, are hyperactive.

The research group showed that a molecule, ARHGAP33 regulates synaptic functions and behaviors via intracellular protein trafficking and that the lack of ARHGAP33 causes neuropsychiatric disorder - related impaired higher brain functions.

A research group led by Osaka University and the University of Tokyo found that the intracellular protein trafficking is important for higher brain functions such as learning and memory.

Some motor neuron diseases are also associated with disruption of motor protein traffic.

The trafficking of proteins between the ER and Golgi must be tightly modulated to maintain the health of the cell and prevent diseases like cancer from taking hold.

A group of researchers led by Professor KIKUCHI Kazuya at the Graduate School of Engineering, Osaka University, clarified the role of a N - glycan chain on glucose transporter type 4 (GLUT4) by developing a method for visualizing intracellular trafficking of proteins.

Protein - protein interactions contributing to the specificity of intracellular vesicular traffProtein - protein interactions contributing to the specificity of intracellular vesicular traffprotein interactions contributing to the specificity of intracellular vesicular trafficking.

They also provide new information on the biogenesis and trafficking of membrane transport proteins, which in time may improve the industrial productivity of yeast.

The trafficking protein Tmed2 / p24beta (1) is required for morphogenesis of the mouse embryo and placenta.

By addressing CaaX processing of Chs4 we try to increase our current understanding on maturation and trafficking of proteins involved in chitin biosynthesis, but also aim to shed light on the still enigmatic biological function of the post-prenylation steps of CaaX processing.

In the last few years, our group has shown that the ZAP70 kinase and its substrate LAT control the polarization of T cells toward the APC and that LAT trafficking to the IS depends on the SNARE protein VAMP7.

The symposium features presentations by Philippa Marrack and John Kappler talking on the T cell repertoire; William Paul on interleukin 4 as a prototypic immunoregulatory cytokine; Timothy Springer on lymphocyte trafficking; Pamela Bjorkman on structural studies of MHC and MHC - related proteins, and Jack Strominger on peptide presentation by class I and II MHC proteins; Thierry Boon on genes coding for tumor rejection antigens, including the first tumor antigen, MAGE - 1; and Philip Greenberg on the modification of T cells for adoptive therapy by retroviral - mediated gene insertion Since then, the symposia series has attracted leading immunologists in the cancer vaccine and antibody fields, providing them with a comprehensive view of the promises and challenges in the development of cancer immunotherapies.

These proteins are not only essential for the trafficking of the glutamate receptors, but also control the gating of the receptor channel.

Timothy Springer, with colleagues Michael L. Dustin and Charles A. Dinarello, identifies and characterizes adhesion molecules, a class of cell surface proteins that function in the interactions of immune cells with other cells, including antigen - specific recognition and cell trafficking: integrin LFA - 1 involved in cytoskeleton and signaling, and intracellular adhesion molecules (ICAMs), which are binding partners (ligands) for LFA - 1 and are increased in inflammatory and autoimmune disease.

Immunophilins are now known to function at the crossroads of protein folding and trafficking, and signal transduction.

Biallelic mutation of UNC50, encoding a protein involved in AChR trafficking, is responsible for arthrogryposis.

Her lab also discovered a hidden regulatory landscape on the surfaces of cellular proteins, which act as traffic cops for telomerase.

Remarkably, researchers pinpointed the protein tip as a type of traffic warden after they replaced it with a protein tip from salmonella's cousin, shigella, another highly contagious bacterium that causes severe diarrhea.

This trafficking requires the interaction of two families of synaptic proteins.

«Lila is a rigorous biophysical chemist, but unlike most chemists who avoid complexity and prefer reductionist type studies, Lila's whole career has been focused on applying chemistry and biophysical methods to the study of peptides and their role in biology as well as protein folding and trafficking in vivo,» says Jeffrey W. Kelly at The Scripps Research Institute.

Modulation of cellular protein trafficking by human immunodeficiency virus type 1 Nef: role of the acidic residue in the ExxxLL motif.

When aSyn was produced at low levels, it made its way to the cell membrane and appeared to regulate chemical trafficking and metabolism of compounds called lipids — what may be normal functions for this protein.

Anterograde trafficking of G protein - coupled receptors: function of the C - terminal F (X) 6LL motif in export from the endoplasmic reticulum.

Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex - dependent trafficking of Rabin8 to the centrosome.

Transmembrane protein OSTA - 1 shapes sensory cilia morphology via regulation of intracellular membrane trafficking in C. elegans.

The trafficking protein GABARAP binds to and enhances plasma membrane expression and function of the angiotensin II type 1 receptor.

Protease - activated Receptor - 4 Signaling and Trafficking Is Regulated by the Clathrin Adaptor Protein Complex - 2 Independent of β - Arrestins.

She moved to the USA and continued to work as a postdoctoral researcher at NICHD / NIH in the laboratory of Dr. Juan S. Bonifacino, where she addressed retrograde trafficking of transmembrane cargoes by retromer protein complexes.

NOP2 and NAF1 both interact with DKC1, and all three proteins are required for the stability, correct assembly and intranuclear trafficking of TERC, the RNA component of telomerase.

A number of downregulated pathways in the regular meditator group versus the other groups defined the meditation effect, including regulation of protein synthesis and trafficking, viral expression and viral infectious cycle.

To study the effects of LRO - related gene mutations, Dr. Huizing is performing fluorescent protein expression studies using patients» cells in order to examine defective intracellular trafficking.

Raised on the knee of science — her father taught her and her two brothers from a young age about geology, physics, and natural history — Alice Ting now stands firmly on her own two feet among the faculty at MIT's Chemistry Department, where her objective is to «simultaneously harness the power of genetics and the power of chemistry» using new technologies developed in her lab for imaging protein trafficking, protein - protein interactions, and enzymatic activity.