New research led by UC San Francisco scientists has revealed that mutations in a gene linked with brain development may dispose people to multiple forms
of psychiatric disease by changing the way brain cells communicate.
Not exact matches
A whopping 34 percent could «conceive
of» killing a patient as a way to end suffering caused
by «
psychiatric disease.»
Huntington's
disease is a brain disorder characterized
by the emergence
of decreased motor, cognitive, and
psychiatric abilities, most commonly appearing in the mid-30s and 40s.
Anxiety disorders, which are characterized
by an inability to control feelings
of fear and uncertainty, are the most prevalent group
of psychiatric diseases.
Scientific explanations for the rise
of CFS cases, a phenomenon dating to the mid-1980s, have mostly focused on viruses, but
psychiatric theories have abounded, too, driven primarily
by the Centers for
Disease Control and Prevention, which promoted the idea that CFS was «hysteria» or hypochondria.
Associations between parental
psychiatric disease and violent offending
by children were stronger for female than male children; suicide attempts
by children were comparable regardless
of sex.
And even if such a demand existed, there was no evidence that genetic counseling could help patients with
psychiatric disorders, which — like most
of the more common
diseases — are caused
by a complex interplay
of multiple genes and variants as well as environmental factors.
The new study — published October 18, 2016 in the journal Molecular Psychiatry — combined genetic analysis
of more than 9,000 human
psychiatric patients with brain imaging, electrophysiology, and pharmacological experiments in mutant mice to suggest that mutations in the gene DIXDC1 may act as a general risk factor for
psychiatric disease by interfering with the way the brain regulates connections between neurons.
New studies — prompted
by a renewed interest in potential applications
of psychedelic drugs for understanding the brain or even treating some
psychiatric diseases — suggest that far - reaching changes in brain connectivity contribute to the altered states
of consciousness and other effects
of an acid trip.
Risks for suicide attempts and violent offending
by children were elevated across virtually the entire spectrum
of parental
psychiatric disease.
Less than a decade ago, anti-NMDA receptor encephalitis was first identified, a
disease characterized
by inflammation
of the brain that causes acute
psychiatric symptoms including psychosis.
Parkinson's
disease affects approximately 7 - 10 million people worldwide and is characterised
by progressive loss
of motor function,
psychiatric symptoms and cognitive impairment.
The study is the result
of several years
of work
by the Schizophrenia Working Group
of the
Psychiatric Genomics Consortium (PGC, http://pgc.unc.edu), an international, multi-institutional collaboration founded in 2007 to conduct broad - scale analyses
of genetic data for
psychiatric disease.
«
By studying the genome, we are getting a better handle on the genetic variations that are making people vulnerable to
psychiatric disease,» said Tom Insel, director
of the National Institute
of Mental Health, which helped fund the study.
Exclusion criteria were insomnia caused
by disease or medication, sleep apnea, regular use
of hypnotic or psychotropic medication, current psychotherapy, presence
of major depression or other serious
psychiatric conditions, or confirmed cognitive impairment.
In Singapore, cancer is still seen as a terminal
disease with little hope
of recovery, and there is also a stigma against psychological counselling and
psychiatric support, facilitated
by the general stigma against mental illness amongt both patients and, paradoxically, healthcare professionals.67 Furthermore, a family - centred model
of decision - making tends to be predominant in Asian populations, 68 and in Singapore this is further encouraged
by public policy such as healthcare subsidies that are based on a calculation
of the immediate family's total income, rather than individual income.69 Beliefs or expectations
of the role that the family caregiver ought to play may thus exist and may influence the way individuals respond to the intervention.
Functional expectations
of caregivers are often huge with multiple responsibilities such as household chores, emotional support, providing transportation and symptom management.4 As cancer survivorship grows, from 50 % in the 70s, to 54 % between 1983 and 1985, to 65 % in 2009, the illness may become a chronic
disease, further stressing caregivers with a cumulative and unrelenting burden
of care and responsibility.5 Psychological morbidity or
psychiatric symptomatology among cancer caregivers is high.6, 7 Levels
of distress have also been shown to be higher than those reported
by patients themselves.8
Other studies have shown that the number
of psychiatric disorders a person has is related to life outcomes in young adulthood, 5 and that co-occurring mental disorders, to a small extent, influenced the consequences
of anxiety and depression.3, 4, 23 More general personal traits such as childhood temperament and intellectual abilities are other individual factors that may be
of importance, 26, 29 but the effects
of intellectual function and
psychiatric disease seem independent
of each other.25 Our results indicated an influence
of family factors, as indicated
by the attenuation
of OR in model 3.
Those whose symptoms were unexplained
by organic
disease were reinterviewed
by one
of us (MS) and a full history and
psychiatric diagnostic interview17 completed to determine eligibility for inclusion.