Sentences with phrase «of pyramidal cells»

A beta 42 first selectively accumulates in the perikaryon of pyramidal cells as discrete, granules that appear to be cathepsin D - positive, suggesting that they may represent lysosomes or lysosome - derived structures.

In addition, they hope to take the spatial recognition experiments to the next level using a new microscopy technology that could show simultaneous activity in both subclasses of pyramidal cells in a freely moving mouse.

To trace the paths of the pyramidal cells and see if subclasses of cells could be distinguished based on their downstream targets.

Not exact matches

A neuron called a pyramidal cell, for instance, has a bushy branch of dendrites (orange in 3 - D computer reconstruction, above) reaching up from its cell body (white circle).

There is nothing extraneous here in this painting of two pyramidal cells, a type of neuron found in the cerebellum and hippocampus.

The team, led by CSHL Professor Z. Josh Huang and including researcher Joshua Gordon, M.D., Ph.D., director of the National Institute of Mental Health, focused on dense crowds of excitatory cells called pyramidal neurons — several hundred of which can connect with a single chandelier cell.

Because each chandelier cell may control the firing of hundreds of pyramidal neurons, it has been suggested that they exert a kind of «veto» power over local excitatory messages.

A recent generation of studies of postmortem brain tissue from people with schizophrenia, particularly from the laboratory of Professor David Lewis and his colleagues at the University of Pittsburgh, have shed light on schizophrenia - related abnormalities in the interplay of the main excitatory neurons, pyramidal neurons, and a specific class of inhibitory nerve cells, called chandelier cells, in the prefrontal cortex.

Fast - spiking interneurons are part of a general class of neurons whose primary role is regulating the activity of the principal cells of the cerebral cortex, known as pyramidal cells.

Neuronal activity is correlated with an influx of calcium ions, which can be tracked with fluorescent dyes or proteins that bind to calcium, as in these pyramidal cells.

For their analyses, the scientists specifically colored the places of origin of axons of so - called pyramidal cells in the hippocampus.

It is a complex, highly organised, structure, whose function relies on vast networks containing two main groups of nerve cells, or neurons: pyramidal neurons and interneurons.

A significant reduction in the context - specific modulation of firing rate was observed in the CA3 pyramidal cells when the mutant mice were transferred from one context to another.

To see what was happening in the brains of these ankyrin - G mutant mice, the researchers analyzed the cell components in inhibitory synapses connecting with pyramidal neurons, finding that two proteins known as GAT1 and GAD67 — responsible for making the neurochemical GABA that dials back nerve impulses — were at much lower levels in the synapses on pyramidal neurons in ankyrin - G mutant mice than in normal mice.

They also found that the disruption of the connectivity of these cells during brain development causes alterations in brain oscillatory activity and disturbs the function of place cells, a type of pyramidal neuron that becomes active when an animal is located in a particular place in its environment.

Cembrowski shared some clues as to what's ahead for him and his colleagues: «We have identified suspect number one in terms of what's responsible for the electrophysiological differences between subiculum pyramidal cells and we hope to investigate that, perhaps using gene editing.»

Recently, researchers demonstrated that pyramidal cells may exhibit heterogeneity within the subiculum; in other words, subclasses of these cells may relay different signals to different areas of the brain.

A cross section of the hippocampus with some pyramidal cells depicted with the major incoming fibres (SC - schaffer collaterals, green), TA (temperoammonic pathway, blue), SH (septohippocampal pathway, black) Figure 3.

Altered patterning of dentate granule cell mossy fiber inputs onto CA3 pyramidal cells in limbic epilepsy.

«We found that, during periods of recurrent network activity, cortical pyramidal cells in vivo and in vitro receive strong barrages of both excitatory and inhibitory postsynaptic potentials, with the inhibitory potentials synchronously controlling the timing of action potentials.»

The inverse relationship between the amyloid plaque density and pyramidal cell density in the AD brain regions also supports this possibility, as does the close correlation between plaque size and the size of local pyramidal cells.

Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells.

CONCLUSIONS: Our findings suggest that excessive intracellular accumulation of A beta 42 - positive material in pyramidal cells can result in cell lysis, and that cell lysis is an important source of amyloid plaques and neuronal loss in AD brains.

Morphologic evidence for spatially clustered spines in apical dendrites of monkey neocortical pyramidal cells.

Action potentials in brain neuron (hippocampal pyramidal cell) before and after blockade of BK - type (potassium) channels.