Hand R *, Bortone D *, Mattar P, N'Guyen L, Heng JI - T, Guerrier S, Boutt E, Peters E, Barnes, AP, Parras C, Schuurmans C, Guillemot F and Polleux F. (2005) Phosphorylation of Neurogenin2 specifies the migration properties and the dendritic morphology
of pyramidal neurons in the neocortex.
Because each chandelier cell may control the firing of
hundreds of pyramidal neurons, it has been suggested that they exert a kind of «veto» power over local excitatory messages.
Chandelier cells tune the
activity of pyramidal neurons by releasing the inhibitory transmitter GABA through complex arrays of connections called cartridges.
They also found that the disruption of the connectivity of these cells during brain development causes alterations in brain oscillatory activity and disturbs the function of place cells, a
type of pyramidal neuron that becomes active when an animal is located in a particular place in its environment.
Finally, these astrocyte - derived neurons typically exhibited morphology
reminiscent of pyramidal neurons, displaying synaptic spines that were targeted by pre-synaptic terminals.
Animal studies have shown that direct glucocorticoid exposure results in a
loss of pyramidal neurons and dendritic branching in the hippocampus, meaning that the organic structure of this brain area was affected by this hormone, likely resulting in a decrease neuronal synapses that would facilitate integration.