Sentences with phrase «of radiation response»

Antagonists of growth hormone releasing hormone (GHRH) given before whole body radiation lead to modulation of radiation response and organ - specific changes in the expression of angiogenesis.

The team at the Institute of Radiation Biology led by Mike Atkinson and Natasa Anasasov have identified several more radiation regulated long non-coding RNA molecules, and are staring to unravel this exciting new aspect of the radiation response.

Not exact matches

The model significantly improved prediction of response to radiation therapy over the use of Gleason score and lymph - node status alone;

This is one of the first research studies to highlight the importance of the location of the metastasis as well as the location of the original primary tumor, in predicting response to radiation therapy.

Led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James), the retrospective study suggested that a pattern of molecules called microRNA (miRNA) in tumor cells might predict patients» response to radiation therapy.

The key is the spore: a bacterial spore, or tough shell, forms in response to harsh environmental conditions such as heat, cold, radiation or the presence of toxic substances such as gold.

A group of researchers at Osaka University found that if DNA damage response (DDR) does not work when DNA is damaged by radiation, proteins which should be removed remain instead, and a loss of genetic information can be incited, which, when repaired incorrectly, will lead to the tumor formation.

The method focuses the analysis on individual birds instead of species averages, making it a much more sensitive way to analyze biochemical responses to radiation.

Preliminary results of a study of patients with prostate cancer show that MR tractography may be a reliable quantitative imaging biomarker to assess prostate cancer treatment response to androgen deprivation and radiation therapy, according to a team of researchers at Brigham and Women's Hospital and Massachusetts General Hospital in Boston.

Last year he received some assistance when the National Institutes of Health awarded Dartmouth $ 3.3 million per year over five years for create its own radiation - response research facility.

By assessing the levels of radiation at the site and measuring the radiation response in the tools, McPherron and his colleagues established that the tools were heated between 280,000 and 350,000 years ago.

Such an inverse dose - response effect contradicts the LNT understanding of radiation action, and is seen as the first mechanistic evidence to explain a non-linear effect.

«New cellular response to radiation exposure: Must we reconsider the risks of low doses?.»

After adjusting for clinical factors in a multivariate model, a CNA in a CFS was determined to be a significant independent predictor of decreased response to radiation therapy and higher incidence of recurring cancer.

Researchers at the Helmholtz Zentrum München now report the discovery of a very unexpected role for one such lncRNA, which they call PARTICLE, in regulating the response of cells to ionizing radiation.

This linear no - threshold (LNT) dose - response relationship has been used to extrapolate the risks of low doses of radiation from epidemiological studies that were done following exposure to much higher doses of radiation (e.g. survivors of the atomic bombings).

Indeed, other investigators have reported previously (32) that the radiation - toxicity syndrome is more severe in p21 - deficient mice than in wild - type mice, and it is associated to an enhanced apoptotic response of the intestine in p21 - null mice.

In the zirconate, this spontaneous generation of secondary defects in response to the primary defect is part of the self - healing process by which the radiation energy is dissipated and volume expansion is avoided.

eBM models organ - level marrow toxicity responses and protective effects of radiation countermeasure drugs, whereas conventional bone marrow culture methods do not.

By combining local radiation therapy and anti-cancer vaccines with checkpoint inhibitors, researchers from the University of Chicago, working with mice, were able to increase the response rate for these new immunotherapy...

June 13, 2016 Radiation and vaccination can magnify effects of immunotherapy By combining local radiation therapy and anti-cancer vaccines with checkpoint inhibitors, researchers from the University of Chicago, working with mice, were able to increase the response rate for these new immunotherapy agents.

Our case series of combined immunotherapy and radiation for mucosal melanoma of the lower genital tract, which demonstrated complete radiographic response in all patients treated, and a complete pathologic response in one patient at the time of surgery, suggests that further studies should be pursued in this area.

This EU - funded programme links groups working on the response of stem cells to low doses of ionising radiation, such as found in medical imaging or nuclear accidents.

Thirty - nine percent of the 31 tumors treated with 24 gray of radiation met the criteria for tumor control — a complete or partial response.

Research techniques — unique to the Kimmel Cancer Center — allow us to study the effects of radiation therapy in ways never before possible and to image, quantify and measure tumor responses in real time.

Therapeutic decision - making is based on the type of tumor rather than its response to a trial of radiation.

Their brains aren't that different in terms of response to radiation.»

Gao K, Helbling EW, Häder DP, Hutchins DA Responses of marine primary producers to interactions between ocean acidification, solar radiation, and warming MEPS 470:167 - 189 Full text in pdf format

[Response: The way the radiation is written in the Uvic model — which is typical for energy balance models of this sort — you can dial in whatever sensitivity parameter you want.

Those levels rose sharply during periods of rapid brain development and in response to radiation, oxidation and other factors known to cause breaks in DNA.

At the American Society of Clinical Oncology (ASCO) 2017 Annual Meeting, we presented monotherapy data of nine patients who received G100 with radiation (no pembrolizumab) that showed 100 % DCR rate, with 44 % of the patients achieved a partial response (PR) based on WHO criteria, which requires at least a 50 % tumor reduction to qualify as a PR.

The rabbit has provided an excellent model system to simulate the response of human tissue to the radiation produced by surgical lasers.

Overall, the five - year survival of patients with a PNET or pineoblastoma is 50 percent to 60 percent, but it is clearly worse among infants or in patients with incomplete surgical removal and poor response to radiation therapy.

Alcohol can have a strong impact on the production of oxidative stress, because it is not metabolized in the liver — leading to alcoholic liver disease.6, 7 The development of oxidative stress is also related to smoking, which suppresses the immune response and damages lung function.8 What may seem like a surprising factor is the use of pharmaceutical drugs and radiation.

Inflammation is usually characterized by redness on the affected area, and can be triggered by many things, including overexertion, immune response to pathogens, injuries, and the effects of chemicals or radiation.

Still, there's no getting around the fact that vitamin D, produced by your skin in response to UV radiation is a primary health benefit of sun exposure, as vitamin D influences an estimated 10 percent of all the genes in your body.

This page outlines a map of assessment through the unit, including skill based questions, short writing responses and extended writing responses including essays.The atmospheric system, including the natural greenhouse effect and energy balance (incoming shortwave radiation and outgoing long wave radiation) Changes in the global energy balance, and the role of feedback loops, resulting from: Glossary - Student should make...

More importantly, this system has the very nice property that the global mean of instantaneous forcing calculations (the difference in the radiation fluxes at the tropopause when you change greenhouse gases or aerosols or whatever) are a very good predictor for the eventual global mean response.

My contribution had its ups and downs — a low point was definitely when Judge Alsup declared «your chart sucks» in response to a powerpoint slide (right) which showed an artist's impression of the Nimbus 4 satellite at the expense of a graph of how the spectrum of outgoing long wave radiation changed in response to rising greenhouse gases between 1970 and 1997.

Reliable data on decadal variability of the Earth's radiation budget are hard to come by, but to provide some reality check I based my setting of the scaling factor between radiative forcing and the SOI / PDOI index on the tropical data of Wielecki et al 2002 (as corrected in response to Trenberth's criticism here.)

Earth's energy balance In response to a positive radiative forcing F (see Appendix A), such as characterizes the present - day anthropogenic perturbation (Forsteret al., 2007), the planet must increase its net energy loss to space in order to re-establish energy balance (with net energy loss being the difference between the outgoing long - wave (LW) radiation and net incoming shortwave (SW) radiation at the top - of - atmosphere (TOA)-RRB-.

But I think he may have missed sufficiently emphasizing this part in his response: ``... top - of - the - atmosphere radiation balance to change positively...»

Adding CO2 does not (at least not before the climate response, which is generally stratospheric cooling and surface and tropospheric warming for increasing greenhouse gases) decrease the radiation to space in the central portion of the band because at those wavelengths, CO2 is so opaque that much or most radiation to space is coming from the stratosphere, and adding CO2 increases the heights from which radiation is able to reach space, and the stratospheric temperatures generally increase with increasing height.

[Response: All forcings are calculated by changing the boundary conditions (in this case the distribution of glacial ice, and looking to see what the change in net radiation is while keeping everything else constant.

[Response: These feedbacks are indeed modelled because they depend not on the trace greenhouse gas amounts, but on the variation of seasonal incoming solar radiation and effects like snow cover, water vapour amounts, clouds and the diurnal cycle.

I think the central point is that of the scale of energy imbalance and the timescale for response: our addition of CO2 reduces outgoing thermal radiation, so incoming energy from the sun is greater than outgoing energy to space.

[Response: They are imposed directly as cyclic changes in the amount (and spectra) of the incoming solar radiation.

Refering to bands where optical thickness is constant over the interval of each band, if the atmospheric LW absorption is limited to some band (that doesn't cover all LW radiation), than increases in OLR in response to surface warming will occur outside that band, so OLR will drop within the band — there will still be some portion of stratospheric or near - TOA cooling that will be transient, but some will remain at full equilibrium.

The equilibrium response to an addition of RF at a level is an increase in net upward flux consisting of LW radiation (the Planck response, PR) plus a convective flux response CR; CR is approximately zero at and above the tropopause in the global time average.

Re 9 wili — I know of a paper suggesting, as I recall, that enhanced «backradiation» (downward radiation reaching the surface emitted by the air / clouds) contributed more to Arctic amplification specifically in the cold part of the year (just to be clear, backradiation should generally increase with any warming (aside from greenhouse feedbacks) and more so with a warming due to an increase in the greenhouse effect (including feedbacks like water vapor and, if positive, clouds, though regional changes in water vapor and clouds can go against the global trend); otherwise it was always my understanding that the albedo feedback was key (while sea ice decreases so far have been more a summer phenomenon (when it would be warmer to begin with), the heat capacity of the sea prevents much temperature response, but there is a greater build up of heat from the albedo feedback, and this is released in the cold part of the year when ice forms later or would have formed or would have been thicker; the seasonal effect of reduced winter snow cover decreasing at those latitudes which still recieve sunlight in the winter would not be so delayed).