The team at the Institute of Radiation Biology led by Mike Atkinson and Natasa Anasasov have identified several more radiation regulated long non-coding RNA molecules, and are staring to unravel this exciting new aspect
of the radiation response.
Antagonists of growth hormone releasing hormone (GHRH) given before whole body radiation lead to modulation
of radiation response and organ - specific changes in the expression of angiogenesis.
Not exact matches
The model significantly improved prediction
of response to
radiation therapy over the use
of Gleason score and lymph - node status alone;
This is one
of the first research studies to highlight the importance
of the location
of the metastasis as well as the location
of the original primary tumor, in predicting
response to
radiation therapy.
Led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James), the retrospective study suggested that a pattern
of molecules called microRNA (miRNA) in tumor cells might predict patients»
response to
radiation therapy.
The key is the spore: a bacterial spore, or tough shell, forms in
response to harsh environmental conditions such as heat, cold,
radiation or the presence
of toxic substances such as gold.
A group
of researchers at Osaka University found that if DNA damage
response (DDR) does not work when DNA is damaged by
radiation, proteins which should be removed remain instead, and a loss
of genetic information can be incited, which, when repaired incorrectly, will lead to the tumor formation.
The method focuses the analysis on individual birds instead
of species averages, making it a much more sensitive way to analyze biochemical
responses to
radiation.
Preliminary results
of a study
of patients with prostate cancer show that MR tractography may be a reliable quantitative imaging biomarker to assess prostate cancer treatment
response to androgen deprivation and
radiation therapy, according to a team
of researchers at Brigham and Women's Hospital and Massachusetts General Hospital in Boston.
Last year he received some assistance when the National Institutes
of Health awarded Dartmouth $ 3.3 million per year over five years for create its own
radiation -
response research facility.
By assessing the levels
of radiation at the site and measuring the
radiation response in the tools, McPherron and his colleagues established that the tools were heated between 280,000 and 350,000 years ago.
Such an inverse dose -
response effect contradicts the LNT understanding
of radiation action, and is seen as the first mechanistic evidence to explain a non-linear effect.
«New cellular
response to
radiation exposure: Must we reconsider the risks
of low doses?.»
After adjusting for clinical factors in a multivariate model, a CNA in a CFS was determined to be a significant independent predictor
of decreased
response to
radiation therapy and higher incidence
of recurring cancer.
Researchers at the Helmholtz Zentrum München now report the discovery
of a very unexpected role for one such lncRNA, which they call PARTICLE, in regulating the
response of cells to ionizing
radiation.
This linear no - threshold (LNT) dose -
response relationship has been used to extrapolate the risks
of low doses
of radiation from epidemiological studies that were done following exposure to much higher doses
of radiation (e.g. survivors
of the atomic bombings).
Indeed, other investigators have reported previously (32) that the
radiation - toxicity syndrome is more severe in p21 - deficient mice than in wild - type mice, and it is associated to an enhanced apoptotic
response of the intestine in p21 - null mice.
In the zirconate, this spontaneous generation
of secondary defects in
response to the primary defect is part
of the self - healing process by which the
radiation energy is dissipated and volume expansion is avoided.
eBM models organ - level marrow toxicity
responses and protective effects
of radiation countermeasure drugs, whereas conventional bone marrow culture methods do not.
By combining local
radiation therapy and anti-cancer vaccines with checkpoint inhibitors, researchers from the University
of Chicago, working with mice, were able to increase the
response rate for these new immunotherapy...
June 13, 2016
Radiation and vaccination can magnify effects
of immunotherapy By combining local
radiation therapy and anti-cancer vaccines with checkpoint inhibitors, researchers from the University
of Chicago, working with mice, were able to increase the
response rate for these new immunotherapy agents.
Our case series
of combined immunotherapy and
radiation for mucosal melanoma
of the lower genital tract, which demonstrated complete radiographic
response in all patients treated, and a complete pathologic
response in one patient at the time
of surgery, suggests that further studies should be pursued in this area.
This EU - funded programme links groups working on the
response of stem cells to low doses
of ionising
radiation, such as found in medical imaging or nuclear accidents.
Thirty - nine percent
of the 31 tumors treated with 24 gray
of radiation met the criteria for tumor control — a complete or partial
response.
Research techniques — unique to the Kimmel Cancer Center — allow us to study the effects
of radiation therapy in ways never before possible and to image, quantify and measure tumor
responses in real time.
Therapeutic decision - making is based on the type
of tumor rather than its
response to a trial
of radiation.
Their brains aren't that different in terms
of response to
radiation.»
Gao K, Helbling EW, Häder DP, Hutchins DA
Responses of marine primary producers to interactions between ocean acidification, solar
radiation, and warming MEPS 470:167 - 189 Full text in pdf format
[
Response: The way the
radiation is written in the Uvic model — which is typical for energy balance models
of this sort — you can dial in whatever sensitivity parameter you want.
Those levels rose sharply during periods
of rapid brain development and in
response to
radiation, oxidation and other factors known to cause breaks in DNA.
At the American Society
of Clinical Oncology (ASCO) 2017 Annual Meeting, we presented monotherapy data
of nine patients who received G100 with
radiation (no pembrolizumab) that showed 100 % DCR rate, with 44 %
of the patients achieved a partial
response (PR) based on WHO criteria, which requires at least a 50 % tumor reduction to qualify as a PR.
The rabbit has provided an excellent model system to simulate the
response of human tissue to the
radiation produced by surgical lasers.
Overall, the five - year survival
of patients with a PNET or pineoblastoma is 50 percent to 60 percent, but it is clearly worse among infants or in patients with incomplete surgical removal and poor
response to
radiation therapy.
Alcohol can have a strong impact on the production
of oxidative stress, because it is not metabolized in the liver — leading to alcoholic liver disease.6, 7 The development
of oxidative stress is also related to smoking, which suppresses the immune
response and damages lung function.8 What may seem like a surprising factor is the use
of pharmaceutical drugs and
radiation.
Inflammation is usually characterized by redness on the affected area, and can be triggered by many things, including overexertion, immune
response to pathogens, injuries, and the effects
of chemicals or
radiation.
Still, there's no getting around the fact that vitamin D, produced by your skin in
response to UV
radiation is a primary health benefit
of sun exposure, as vitamin D influences an estimated 10 percent
of all the genes in your body.
This page outlines a map
of assessment through the unit, including skill based questions, short writing
responses and extended writing
responses including essays.The atmospheric system, including the natural greenhouse effect and energy balance (incoming shortwave
radiation and outgoing long wave
radiation) Changes in the global energy balance, and the role
of feedback loops, resulting from: Glossary - Student should make...
More importantly, this system has the very nice property that the global mean
of instantaneous forcing calculations (the difference in the
radiation fluxes at the tropopause when you change greenhouse gases or aerosols or whatever) are a very good predictor for the eventual global mean
response.
My contribution had its ups and downs — a low point was definitely when Judge Alsup declared «your chart sucks» in
response to a powerpoint slide (right) which showed an artist's impression
of the Nimbus 4 satellite at the expense
of a graph
of how the spectrum
of outgoing long wave
radiation changed in
response to rising greenhouse gases between 1970 and 1997.
Reliable data on decadal variability
of the Earth's
radiation budget are hard to come by, but to provide some reality check I based my setting
of the scaling factor between radiative forcing and the SOI / PDOI index on the tropical data
of Wielecki et al 2002 (as corrected in
response to Trenberth's criticism here.)
Earth's energy balance In
response to a positive radiative forcing F (see Appendix A), such as characterizes the present - day anthropogenic perturbation (Forsteret al., 2007), the planet must increase its net energy loss to space in order to re-establish energy balance (with net energy loss being the difference between the outgoing long - wave (LW)
radiation and net incoming shortwave (SW)
radiation at the top -
of - atmosphere (TOA)-RRB-.
But I think he may have missed sufficiently emphasizing this part in his
response: ``... top -
of - the - atmosphere
radiation balance to change positively...»
Adding CO2 does not (at least not before the climate
response, which is generally stratospheric cooling and surface and tropospheric warming for increasing greenhouse gases) decrease the
radiation to space in the central portion
of the band because at those wavelengths, CO2 is so opaque that much or most
radiation to space is coming from the stratosphere, and adding CO2 increases the heights from which
radiation is able to reach space, and the stratospheric temperatures generally increase with increasing height.
[
Response: All forcings are calculated by changing the boundary conditions (in this case the distribution
of glacial ice, and looking to see what the change in net
radiation is while keeping everything else constant.
[
Response: These feedbacks are indeed modelled because they depend not on the trace greenhouse gas amounts, but on the variation
of seasonal incoming solar
radiation and effects like snow cover, water vapour amounts, clouds and the diurnal cycle.
I think the central point is that
of the scale
of energy imbalance and the timescale for
response: our addition
of CO2 reduces outgoing thermal
radiation, so incoming energy from the sun is greater than outgoing energy to space.
[
Response: They are imposed directly as cyclic changes in the amount (and spectra)
of the incoming solar
radiation.
Refering to bands where optical thickness is constant over the interval
of each band, if the atmospheric LW absorption is limited to some band (that doesn't cover all LW
radiation), than increases in OLR in
response to surface warming will occur outside that band, so OLR will drop within the band — there will still be some portion
of stratospheric or near - TOA cooling that will be transient, but some will remain at full equilibrium.
The equilibrium
response to an addition
of RF at a level is an increase in net upward flux consisting
of LW
radiation (the Planck
response, PR) plus a convective flux
response CR; CR is approximately zero at and above the tropopause in the global time average.
Re 9 wili — I know
of a paper suggesting, as I recall, that enhanced «backradiation» (downward
radiation reaching the surface emitted by the air / clouds) contributed more to Arctic amplification specifically in the cold part
of the year (just to be clear, backradiation should generally increase with any warming (aside from greenhouse feedbacks) and more so with a warming due to an increase in the greenhouse effect (including feedbacks like water vapor and, if positive, clouds, though regional changes in water vapor and clouds can go against the global trend); otherwise it was always my understanding that the albedo feedback was key (while sea ice decreases so far have been more a summer phenomenon (when it would be warmer to begin with), the heat capacity
of the sea prevents much temperature
response, but there is a greater build up
of heat from the albedo feedback, and this is released in the cold part
of the year when ice forms later or would have formed or would have been thicker; the seasonal effect
of reduced winter snow cover decreasing at those latitudes which still recieve sunlight in the winter would not be so delayed).