The four flashing colors would reveal the base sequence
of each replica DNA, which would tell them the base sequence of the matching RNA from which it was derived.
They succeeded by selectively turning on just a fraction of those flashing dots at any given time, so they could distinguish single balls
of replica DNA flashing across the cellular landscape.
Daugharthy first devised an algorithm to locate the sequence
of the replica DNA with the known sequence of genes in the human genome.
Not exact matches
Now, scientists at Princeton have used «designer chromatin'templates — highly customized
replicas of cellular
DNA and histone proteins, the scaffolding proteins around which
DNA is wrapped — to reveal new details about Suv39h1's mechanism.
By analogy, the scientists sought to fix RNA in place in the cell, make a tiny ball with many matching
DNA replicas of each RNA, then adapt next - gen
DNA sequencing so it worked in fixed cells.