Such studies will aid diagnosis and treatment
of rhabdomyosarcoma.
«A better understanding of the machinery
of rhabdomyosarcoma could enable entirely new treatment approaches.
About 350 new cases
of rhabdomyosarcoma are identified each year in the U.S., making it the most common soft tissue tumor in children.
About 60 percent
of rhabdomyosarcoma patients have tumors of the embryonal subtype, and about 25 percent have the alveolar subtype.
This analysis suggests that a rare subset of tumor cells harbor different genetic alterations and that those cells serve as the seeds for the recurrence
of rhabdomyosarcoma.»
Not exact matches
We had just gotten through a successful tax season when the unthinkable happened: The youngest
of our three children, 4 - year - old Nicholas, was diagnosed with
rhabdomyosarcoma, a cancer
of the connective tissue.
«Studies like the current one involving
rhabdomyosarcoma are giving us a close - up look at the way cancer evolves in response to treatment,» said study co-author Richard K. Wilson, Ph.D., director
of The Genome Institute at Washington University School
of Medicine in St. Louis, where scientists have extensive expertise analyzing tumor recurrence using whole - genome sequencing.
Drugs that enhance a process called oxidative stress were found to kill
rhabdomyosarcoma tumor cells growing in the laboratory and possibly bolstered the effectiveness
of chemotherapy against this aggressive tumor
of muscle and other soft tissue.
«Overall, survival for patients with recurrent
rhabdomyosarcoma is just 17 percent, and until now nothing was known about how tumors evolve in response to therapy,» said corresponding author Michael Dyer, Ph.D., a member
of the St. Jude Department
of Developmental Neurobiology and a Howard Hughes Medical Institute Investigator.
His experiments revealed the cells that became
rhabdomyosarcoma were not muscle cells, but were immature cells that would mature into cells lining the inner surface
of blood vessels.
The unexpected discovery that
rhabdomyosarcoma is not really a muscle cancer may offer broader lessons for researchers seeking the cellular origin
of cancers.
All seven institutions used IGRT for treatment
of ependymoma (cancer
of the tissue
of the brain or spinal cord), abdominal and pelvic sarcoma, and
rhabdomyosarcoma (cancer
of the muscles attached to the bones).
Pax3: Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar
rhabdomyosarcoma cell
of origin.
At the Solid Tumor Oncology Program, part
of C.S. Mott Children's Hospital at the University
of Michigan, we provide comprehensive, multidisciplinary care for children with
rhabdomyosarcoma.
At the Children's Oncology Group, we work on the design and implementation
of studies regarding Ewing's sarcoma, osteosarcoma,
rhabdomyosarcoma, and other soft tissue sarcomas.
A
rhabdomyosarcoma can occur in many places in the body, most commonly around the structures
of the head and neck, within the urogenital tract, and in the arms or legs.
In 2001, doctors diagnosed then - four - year - old Jimmy Mohan with
rhabdomyosarcoma, an aggressive form
of childhood cancer.
«The way we manage children with
rhabdomyosarcoma today is based on what he did through all those years
of tireless work in the Pediatric Oncology Group.
Research led by Mark Hatley, MD, PhD,
of St. Jude Oncology, has shown that certain embryonal
rhabdomyosarcoma tumors arise from early endothelial cells instead.
Dr. Jason Yustein's research laboratory is utilizing tissue - specific expression
of an oncogenic p53 mutant to form novel, applicable transgenic mouse models
of metastatic osteosarcoma and
rhabdomyosarcoma, both conditions that have particularly poor patient outcmes.
DATE: April 2 TIME: 3:35 p.m. LOCATION: Room 144, Level 1, Washington Convention Center TITLE: Non-myogenic origin
of embryonal
rhabdomyosarcoma ABSTRACT: 1036
In addition to research on
rhabdomyosarcoma, the Ignatius laboratory has also generated new syngeneic zebrafish models
of aggressive Malignant Nerve Sheath Tumors and hemangiosarcomas for which there are no effective treatments.
In vivo imaging
of tumor - propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal
rhabdomyosarcoma.
As noted in Part I
of this article, γ - tocopherol is preferentially metabolized into γ - CEHC, and the latter compound has been observed to exert much stronger anti-proliferative activity than α - CEHC in prostate cancer cells and
rhabdomyosarcoma cells.
In another case a 4 - month old dog was affected with embryonal
rhabdomyosarcoma of the trachea.
There are various types
of bladder tumors like squamous cell carcinoma (arise in the epithelial cells), adenocarcinoma (arise in the glandular epithelium), undifferentiated carcinoma,
rhabdomyosarcoma (tumor
of the striated muscle - form
of fibers combined into parallel fibers like the skeletal and the cardiac muscles), fibroma (tumors made
of fibrous or connective tissue.
But the average age
of embryonal
rhabdomyosarcoma is 8.2 years.