Sentences with phrase «of ribosomal»

Objectives: To investigate the context of the ribosomal RNA methyltransferase gene armA in carbapenem - resistant global clone 2 (GC2) Acinetobacter baumannii isolates from Singapore.

In addition, the monopolin complex maintains the integrity and silencing of ribosomal DNA (rDNA) repeats in the nucleolus.

BAZ2A is an essential component of the nucleolar remodeling complex (NoRC), which mediates recruitment of histone modifyine enzymes and DNA methylase involved in the silencing of ribosomal RNA transcription by RNA polymerase I. BAZ2B is believed to be involved in regulating nucleosome mobilization along linear DNA.

The silence of the ribosomal RNA genes (Cellular and Molecular Life Sciences 62: 2067 - 2079), The Silence of the Labs (Defence Horizons 2003), The Science of the Lambs (Nature 391).

Sweet T, Yen W, Khalili K, Amini S. Evidence for involvement of NFBP in processing of ribosomal RNA.

Evidence for involvement of NFBP in processing of ribosomal RNA.

Biological Function of Ribosomal Protein L10 on Cell Behavior in Human Epithelial Ovarian Cancer Jimin Shi, Lingyun Zhang, Daibing Zhou, Jinguo Zhang, Qunbo Lin, Wencai Guan, Jihong Zhang, Weimin Ren, Guoxiong Xu J. Cancer 2018; 9 (4): 745 - 756.

In the light of evidence suggesting that the oldest region of the ribosomal RNA tree lies on the branch leading into the bacterial kingdom, Aquifex provided grounds for the claim that it was the nearest living cousin of the universal ancestor.

Attempts to decode and translate such «nonstop - mRNAs» leads to a complete stalling of the ribosomal machinery, resulting in effectively blocking continued protein synthesis.

For three, he saw a loss of ribosomal DNA copies in the cancer cells relative to the normal cells.

First author Baoshan Xu, Ph.D., a former postdoctoral research associate in the Gerton Lab now starting his own lab at Sun Yat - sen University in China, worked with Hua Li, Ph.D., to use computational methods to count the number of copies of ribosomal DNA in normal and cancer cells of 162 patients from the eight projects.

«The fast tempo of the ribosomal RNA dance lets us detect very close relationships between different yeasts.»

Previous studies on budding yeast showed that whittling down the number of copies of ribosomal DNA created a genome that was very sensitive to DNA damage.

The cells somehow managed to be highly proliferative, made more ribosomal RNA, and synthesized more protein, all with fewer copies of ribosomal DNA.

The few studies that have included analysis of ribosomal DNA thus far have shown that the number of copies of the repetitive sequences expand and contract all the time.

This piece of DNA, called the 16S subunit of ribosomal RNA, does not change quickly over time, however, so it gives a very coarse timeline for the evolution of bacteria.

The study, published in Science and co-authored by University of Cambridge and King's College London, shows that the genetic variation of ribosomal DNA (rDNA) could be driving how the environment within the womb determines an offspring's attributes.

Lead researcher Professor Vardhman Rakyan from QMUL said: «The fact that genetic variation of ribosomal DNA seems to play such a major role suggests that many human genetics studies could be missing a key part of the puzzle.

Domain II of EF - P interacts with the ribosomal protein L1, which results in the largest movement of the L1 stalk that has been observed in the absence of ratcheting of the ribosomal subunits.

Not exact matches

There is no such «direct» evolution: animals, bacteria, and algae have a common ancestor from which they have diverged, as can be shown by aligning and comparing amino acid sequences of proteins and nucleotide sequences of homologous ribosomal RNA molecules that are found in both bacteria and vertebrates.

Crystal structures of the 30S ribosomal subunit in complex with messenger RNA and cognate transfer RNA in the A site, both in the presence and absence of the antibiotic paromomycin, have been solved at between 3.1 and 3.3 angstroms resolution.

Genes encoding ribosomal proteins, DNA replication and repair machinery, oxidative stress, and purine biosynthesis were differentially expressed in Wolbachia during the development of B. malayi female worms, suggesting a role of the bacteria in worm reproduction.

That was surprising, he explains, because «fibrillarin resides deep within the nucleolus of the host cell... [where it] methylates ribosomal RNA molecules, which then go on to form ribosomes,» but its full function may not be completely understood.

The chemical mechanisms of RNA - catalyzed reactions are discussed with emphasis on the self - splicing ribosomal RNA precursor of Tetrahymena and the enzymatic activities of its intervening sequence RNA.

Ribosomes, the cellular factories that manufacture proteins, contain both RNA and protein, but exactly how all of the different ribosomal components contribute to protein synthesis is still not clear.

It spans both ribosomal subunits with its amino - terminal domain positioned adjacent to the aminoacyl acceptor stem and its carboxyl - terminal domain positioned next to the anticodon stem - loop of the P site — bound initiator tRNA.

The contacts between wild - type M1 RNA and its substrate are in a region that resembles part of the transfer RNA «E» (exit) site in 23S ribosomal RNA.

Splicing of the Tetrahymena ribosomal RNA precursor is mediated by the folded structure of the RNA molecule and therefore occurs in the absence of any protein in vitro.

Expression of the Escherichia coli tryptophanase operon depends on ribosome stalling during translation of the upstream TnaC leader peptide, a process for which interactions between the TnaC nascent chain and the ribosomal exit tunnel are critical.

Coupling of Tetrahymena ribosomal RNA splicing to beta - galactosidase expression in Escherichia coli

«Ataluren stimulates ribosomal selection of near - cognate tRNAs to promote nonsense suppression.»

Now, as Thomas Cech explains in his Perspective, atomic resolution of the structure of the large ribosomal subunit reveals that, as predicted by those convinced of a prebiotic RNA world, RNA is the catalytic component with proteins being the structural units that support and stabilize it (Ban et al., Nissen et al., Muth et al.).

We analyzed ∼ 78 million base pairs of unique DNA sequence and 2062 polymerase chain reaction — amplified 16S ribosomal DNA sequences obtained from the fecal DNAs of two healthy adults.

We examined 13,355 prokaryotic ribosomal RNA gene sequences from multiple colonic mucosal sites and feces of healthy subjects to improve our understanding of gut microbial diversity.

This set includes various ribosome builders, as well as other proteins that process and transcribe ribosomal RNA, a necessary step before the ribosomes can be assembled and pushed out of the nucleolus.

In vivo mutational analysis of this nucleotide indicates that it has an essential role in ribosomal function.

Biochemical and crystallographic evidence suggests that 23S ribosomal RNA (rRNA) is the catalyst of peptide bond formation.

Both substrate analogs are contacted exclusively by conserved ribosomal RNA (rRNA) residues from domain V of 23S rRNA; there are no protein side - chain atoms closer than about 18 angstroms to the peptide bond being synthesized.

Using the atomic structures of the large ribosomal subunit fromHaloarcula marismortui and its complexes with two substrate analogs, we establish that the ribosome is a ribozyme and address the catalytic properties of its all - RNA active site.

tiRNA is a type of small RNA that suppresses global protein synthesis, while rRNA or ribosomal RNA is a type of RNA molecule that enhances protein synthesis.

So the ribosomal fragments that we were finding explain a lot of things, explains among other things the observation that CCD seems to be caused by everything.

These studies only looked at a single copy part of individuals» genomes and never at ribosomal DNA.

After six to eight weeks, the microbial content of the mice's feces were analyzed by 16S ribosomal RNA gene sequencing, which showed that approximately 20 kinds of oral bacteria were present in these mice.

Of the 80 ribosomal proteins examined, 31 changed protein levels in at least one cell type, Barna said.

The intervening sequence RNA excised from the ribosomal RNA precursor of Tetrahymena forms linear and circular oligomers when exposed to a heating - cooling treatment in vitro.

The team then examined the ribosomal proteins found in each type of cell.

«We have ample evidence that hundreds of the oldest ribosomal proteins still start with a valine or a leucine code and do not have the codon for methionine in the DNA,» Duax said, referring to proteins found in basic cell components called ribosomes.

Even with the advent of DNA sequencing and genetic identification, this was generally done with one particular ribosomal gene.

Moreover, a funnel - shaped pore in the Sec61 oligomer aligned with the exit of a tunnel traversing the large ribosomal subunit, strongly suggesting that both structures function together in the translocation of proteins across the endoplasmic reticulum membrane.

He hopes to test samples of martian soil for ancient ribosomal RNA gene sequences that are conserved in all of Earth's known life forms.