Sentences with phrase «of scaffolding proteins»

Homer 1, an actin binding protein that is induced by BDNF [72], belongs to a family of scaffolding proteins that localize at the postsynaptic density (PSD)[73, 74] and is believed to play a critical role in signal transduction, synaptogenesis and receptor trafficking at synapses [75].

The other family is comprised of a family of scaffolding proteins that bind to the auxiliary subunits and thereby anchor the receptors at the synapse.

So, rather than the number of AMPA receptors themselves, the abundance of scaffolding proteins appears to determine synaptic strength, effectively allowing AMPA receptors to receive signals from glutamate.

PDZ interactions regulate rapid turnover of the scaffolding protein EBP50 in microvilli.

Not exact matches

The research team of Prof. Markus Rüegg at the Biozentrum, University of Basel, has now designed two proteins that stabilize the cell scaffolding link it to the muscle fiber and thereby restore muscle structure and function.

They stripped the vein of all the donor's cells using strong detergents, leaving just the underlying protein scaffold.

Now, scientists at Princeton have used «designer chromatin'templates — highly customized replicas of cellular DNA and histone proteins, the scaffolding proteins around which DNA is wrapped — to reveal new details about Suv39h1's mechanism.

When newly hatched majors were injected with molecules that increased the number of small chemical groups attached to their DNA's protein scaffolding, they behaved like minors.

«When the sperm enters the egg cell, the densely compacted male chromatin has to be entirely «unpacked» and restructured around protein scaffolds called histones,» explained Sabrina Ladstätter, first author of the study.

The egg's very structure, its scaffolding of proteins that guide the chromosomes during cell division, may also play a key role in turning on the necessary genes.

Claudio Vita and his colleagues at the protein engineering department of CEA, the French nuclear research agency in Gif - sur - Yvette, are using the toxins found in scorpion venom as a chemical scaffold to build novel proteins for use as drugs (Proceedings of the National Academy of Sciences, vol 92, p 6404).

The injection is made up of a mixture of VentriGelTM, a hydrogel derived from scaffolding protein that is extracted naturally from the heart.

A series of biochemical experiments found that the mechanical force disrupted proteins called integrins that help anchor cells to the scaffold of protein that surrounds them.

In an increasing number of biological signaling processes, scaffold proteins have been found to play a central role in physically assembling the relevant molecular components.

The role of these gels is to mimic the natural environment of the stem cells, which provides them with a protein - and sugar - rich scaffold called the «extracellular matrix,» upon which the stem cells build specific body tissues.

This Biotechnology and Biological Sciences Research Council (BBSRC) funded collaborative project between the University of Kent, University College London and the University of Bristol entitled Engineered synthetic scaffolds for organizing proteins within the bacterial cytoplasm is now published in the journal Nature Chemical Biology.

Whereas the team's model proved that the presence of more scaffolding proteins available at the far downstream end of the neuron (and into the synapse) to AMPA receptors increased during LTP, they found the opposite condition for LDP.

The latter is a so - called chaperone protein that helps guide the attachment of the protein H3.3 to compact looping fibers of DNA and its protein scaffolding, which are collectively called chromatin.

Engineered RNA modules were assembled into discrete, one - dimensional, and two - dimensional scaffolds with distinct protein - docking sites and used to control the spatial organization of a hydrogen - producing pathway.

Bressloff, along with mathematical biologist Berton Earnshaw, conceived of the dendritic spine — the mushroom shape at the downstream end of the neuron — as a two - compartment box: On the far downstream end, essentially in the synapse, scaffolding proteins suspend AMPA receptors so they can bind glutamate signals coming from the upstream neuron.

Beyond that, he continues, «at the timescale of hours, scaffolding proteins can be moved in and out, so again things would lose the memory, so you need something else, like changing the actual structure of the dendritic spine.»

With as many as a thousand tubes fitting into each cell, the tubular scaffold can be used to increase the bacteria's efficiency to make commodities and provide the foundation for a new era of cellular protein engineering.

Perineuronal nets (PNNs), as they are known today, are scaffolds of linked proteins and sugars that resemble cartilage.

Presented in the IOP Publishing journal Biofabrication, the realistic 3D model consists of a scaffold of fibrous proteins coated in cervical cancer cells.

The three - dimensional tumour model consists of a scaffold of fibrous proteins coated in cervical cancer cells.

Researchers at the Okinawa Institute of Science and Technology Graduate University (OIST) have mapped the points along the genome where a scaffolding protein crucial to maintaining the genome's structure binds.

Histones are proteins that serve as a scaffold for coiling up the DNA into the tight space of the nucleus.

Some examples of these nanoscale protein materials are scaffolds to anchor cellular activities, molecular motors to drive physiological events, and capsules for delivering viruses into host cells.

The EB family of proteins helps regulate this process and can act as a scaffold for other proteins involved in pushing the microtubule chain forward.

The team found that the Amyloid beta proteins entered the cells of the retina within 24 hours of exposure and then began to break the cell's scaffold structure.

Such biological systems arrange chromophores in a precise manner on rigid scaffolds composed of protein.

In the first, decel step — short for decellularisation — organs from dead donors are treated with detergents that strip off the soft tissue, leaving just the «scaffold» of the organ, built mainly from the inert protein collagen.

In 2009, Billy Hudson of Vanderbilt University in Nashville and colleagues first noted that protein scaffolds in fruit flies have these sulfilimine bonds, but the researchers didn't know if the bonds were common.

BOND OF LIFE A link between nitrogen and sulfur atoms (bond shown in green) helps hold together protein strands (yellow and white) that create a cellular scaffold essential for tissue and organ formation.

Each neuron contains hundreds of long, cylindrical protein structures, called microtubules, that serve as scaffolding.

In animal tissues and organs, cells lock into a scaffold of collagen proteins that allows the cells to stick together and coordinate activities, such as tissue repair.

One of the features that makes higher organisms unique is their cytoskeleton — a scaffolding of proteins that controls cell shape.

A light scaffold of sugars (gray and red, above) surrounds most human proteins.

The «parts list» in these processes is similar: Microtubules, semi-rigid tubes of protein, can serve within the cell as scaffolding, roadways, and a building material for machinery; some proteins serve as fasteners, binding and releasing other materials; and motor proteins use chemical energy to push and pull materials along microtubules, or move the microtubules themselves.

The majority of proteins found were identified as adaptor proteins, which serve as scaffolds within the Adherens Junction.

Enzymes consist of an active site - a metal where the reaction happens with connections to the rest of the protein - and a protein scaffold surrounding the active site.

Bones are made of a mineral and protein scaffold filled with bone cells.

To understand the role of the protein scaffold in enzymes, Shaw's team incorporated an enzyme - like OCS to these well - studied catalysts.

That PNNL research team, led by Dr. Wendy Shaw, predicted that many parts of the protein scaffold play critical roles in catalytic activity and efficiency instead of only the active site.

They speculate that the normal protein is recruited to the nucleus to provide a supporting scaffold for a construction crew of DNA repair proteins.

Perilipin is a scaffolding protein allowing co-evolution of interacting domains and divergence of non-docking sequences, thus the function can be conserved even with limited amino acid conservation across species.

Regulation of Postsynaptic Structure and Function by an A-Kinase Anchoring Protein — Membrane - Associated Guanylate Kinase Scaffolding Complex.

Near - atomic cryo - EM imaging of a small protein displayed on a designed scaffolding system, Proceedings of the National Academy of Sciences (2018).

Regulation of cell signaling dynamics by the protein kinase - scaffold Ste5.

Hyperosmotic Induction of Mitogen - Activated Protein Kinase Scaffolding.