Similar approaches are applied to the neuropathology
of schizophrenia and autism.
«Aberrant synapse formation is important in the pathogenesis
of schizophrenia and autism,» says Osaka University Professor Toshihide Yamashita, one of the authors of the study.
Not exact matches
Childhood
schizophrenia is rare
and can be difficult to tell apart from other developmental disorders
of childhood, such as
autism.
According to Dr. Keith Wolford, author
of the Devil in the Milk, there is a correlation in the consumption
of A1 cow proteins
and the incidence
of type 1 diabetes, autoimmune disease, heart disease,
autism,
and schizophrenia.
But what
of suggestions that A2 milk provides levels
of protection from
autism in children, as well as
schizophrenia, diabetes
and heart disease?
Back then, it was hypothesised that the A1 beta - casein protein found in the milk
of some cows was a risk factor for diabetes, heart disease
and possibly also
schizophrenia and autism.
A2 Corp claimed the beta casein A1 found in most cows» milk sold in New Zealand had been linked with the development
of coronary heart disease, childhood diabetes
and also implicated in
autism and schizophrenia.
There are also some controlled trials associating wheat gluten with various disorders
of the brain, including
schizophrenia,
autism and cerebellar ataxia (45, 46, 47).
Studies suggest that diet
and stress modify sperm epigenetically
and increase an offspring's risk
of heart disease,
autism and schizophrenia.
The effect
of paternal age on
autism,
schizophrenia,
and ADHD may be greater than previously thought
The Muotri lab uses induced pluripotent stem cells from patients with
autism and schizophrenia to look for biomarkers
of these conditions.
«The interaction between the two types
of neurons could also help explain the presence
of seizures in patients with
schizophrenia, dementia
and some forms
of autism.»
Altered patterns
of variability were observed in the brain's default network with
schizophrenia,
autism and Attention Deficit Hyperactivity Disorder (ADHD) patients.
In the heady postwar years, hundreds
of promising studies were conducted in the United States, Canada,
and Europe on the use
of LSD
and other psychedelics, like peyote, to treat such psychiatric maladies as
schizophrenia,
autism, drug addiction, alcoholism,
and chronic depression.
Studies have identified an association between maternal infection
and inflammation
and preterm birth, in addition to the development
of cerebral palsy
and neuropsychiatric conditions such as
schizophrenia and autism.
The researchers identified for the first time master genes that they believe control hundreds
of other genes which are linked to Alzheimer's disease, Parkinson's disease, post-traumatic stress disorder, stroke, attention deficit hyperactivity disorder,
autism, depression,
schizophrenia and other disorders.
Working with this hypothesis, the researchers conducted a statistical analysis
of the CX3CR1 gene in over 7000
schizophrenia and autism patients
and healthy subjects, finding one mutant candidate, a single amino acid switch from alanine to threonine, as a candidate marker for prediction.
Its use was later extended to the study
of diseases like Alzheimer's,
schizophrenia,
autism,
and stroke.
Risks for
autism and schizophrenia rise for kids
of older fathers,
and a new genetic study suggests why
Researchers hope that figuring out handedness will help them better understand brain organization
and the causes
of conditions such as dyslexia, stuttering,
autism and schizophrenia.
Lipkin
and Hornig have worked together for 21 years trying to tease out the impact
of infection
and immunity on brain disorders such as
autism and schizophrenia,
and more recently CFS / ME.
The immune system's reach within the CNS is extensive, probably contributing to the initiation
and pathogenesis
of neurodegenerative diseases, neurodevelopmental disorders such as
autism,
and mental health disorders such as
schizophrenia.
Further research showed that fetal mice bred to lack these molecules — like animals lacking MHCI,
and like humans with
autism or
schizophrenia — undergo inadequate synaptic pruning in some parts
of their brains.
The results
of this study not only advance science's understanding
of the links between genes, the brain
and behavior, but may lead to new insight into such disorders as
autism, Down syndrome
and schizophrenia.
At Caltech, developmental neurobiologist Paul Patterson found he could induce the core symptoms
of autism and schizophrenia in mice by giving their mothers the flu during pregnancy, or by arousing their immune systems in utero with an injection
of foreign RNA.
The largest
of its kind, the study examined genetic data in 100,000 individuals including 40,000 people with a diagnosis
of schizophrenia and also found that some
of the genes identified as increasing risk for
schizophrenia have previously been associated with other neurodevelopmental disorders, including intellectual disability
and autism spectrum disorders.
The results fit with other evidence that
autism may be caused by overdevelopment
of specific brain regions
and schizophrenia by underdevelopment, says Crespi.
The model expands the research toolkit for investigations
of social behaviors
and psychiatric diseases like
autism and schizophrenia.
Deletions that remove some
of these enhancers have been linked to
schizophrenia,
autism, intellectual disability
and other disorders involving the brain, Carmona - Mora said.
Similarly, many problems related to attention — including attention - deficit hyperactivity disorder, drug addiction, some forms
of autism,
and schizophrenia — have been associated with a dopamine deficit.
Of the many disorders that can afflict the brain,
schizophrenia and autism are among the most inscrutable.
The same conflict that gives rise to
autism and schizophrenia may be at work in all
of us, nudging us one way or another on the spectrum from father - brain to mother - brain.
The findings suggest a new avenue
of exploration for understanding the origin
of disorders such as
autism and schizophrenia.
The root cause
of psychiatric illnesses such as bipolar disorder, major depressive disorder
schizophrenia,
autism and ADHD is not fully understood.
Several neurological disorders, including
autism and schizophrenia, are thought to be driven in part by the failure
of myelin to properly surround axons during development.
They contend that upsets in the tug -
of - war between imprinted genes in the brain could help explain the origins
of some mental illnesses, including
autism and schizophrenia.
One
of the most striking contrasts between
autism and schizophrenia is how they affect the ability to understand others.
They contend that mental illness can be thought
of as occupying a spectrum, with
autism at one end
and schizophrenia, bipolar disorder
and depression at the other.
On one hand, a number
of recently identified genetic contributors to
schizophrenia and autism interact closely with the WNT system.
To grasp the implications, Stefánsson's team compared the whole - genome sequences
of 78 Icelandic people diagnosed with
autism or
schizophrenia with the sequences
of their fathers
and mothers.
In their new paper, Cheyette
and his team examined the gene DIXDC1 — a key piece
of the WNT signaling pathway that is active in tissues
of the brain
and interacts with DISC1, a gene implicated in
schizophrenia, depression, bipolar disorder,
and autism spectrum disorders.
Statistically significant hazard ratios for specific groups
of psychiatric disorders were found for
schizophrenia and psychoses (1.27, 1.16 - 1.38), affective disorders (1.32, 1.25 - 1.39), anxiety
and other neurotic disorders (1.37, 1.32 - 1.42), mental
and behavioural syndromes including eating disorders (1.13, 1.04 - 1.24), mental retardation (1.28, 1.17 - 1.40), mental development disorders including
autism spectrum disorders (1.22, 1.16 - 1.28),
and behavioural
and emotional disorders including attention deficit hyperactivity disorder (ADHD)(1.40, 1.34 - 1.46), when compared with rates in naturally conceived children.
Mutations seen in people with
autism,
schizophrenia,
and bipolar disorder cause loss
of synapses in mice
First, an analysis
of genomic data from 6,000 patients with
autism spectrum disorders, 1,000 patients with bipolar disorder,
and 2,500 patients with
schizophrenia by co-first author Pierre - Marie Martin, PhD, a postdoctoral researcher in Cheyette's lab, revealed that disruptive mutations in the main neuronal form
of DIXDC1 were present about 80 percent more often in psychiatric patients (0.9 percent had mutations) compared to healthy controls (0.5 percent had mutations).
The new findings, published 21 January in
Schizophrenia Research, support an alternate theory:
Autism and schizophrenia are independent outcomes
of the same genetic syndrome.
Two years later, the team received funding for a larger - scale investigation, evaluating a whole suite
of social skills in 54 individuals with
schizophrenia, 54 with
autism and average intelligence quotients (IQ)
and 56 typical adults.
Many
of the eight genes are active during brain development
and may play a role in neuropsychiatric disorders such as
autism and schizophrenia, Sanders says.
This idea
of finding shared neural processes presupposes that the same problems explain the social difficulties seen in people with
autism and those with
schizophrenia — an idea that Sasson
and Pinkham's work has brought into question.
According to that edition
of the DSM, there was no overlap:
Autism and schizophrenia could not co-occur.
By 1980, the «Diagnostic
and Statistical Manual
of Mental Disorders» (DSM) listed
autism and schizophrenia as distinct diagnoses.