Sentences with phrase «of scrapie»

PERNICIOUS PROTEINS This 1960 image of American sheep shows the animals rubbing against a fence rail — an early symptom of scrapie and how the disease got its name.

Not exact matches

The idea is that scrapie prions might somehow interfere with the infectivity of BSE prions.

Prion specialist Moira Bruce of the Institute for Animal Health's Neuropathogenesis Unit in Edinburgh says that sheep experimentally infected with BSE become ill about as fast as sheep naturally infected with scrapie.

With the scale of the nvCJD threat to public health still unclear, scientists have been busy investigating the relationship between the strains of prions blamed for neurodegenerative illnesses, including the presumed connection between BSE and scrapie.

Degenerative brain diseases like mad cow disease (officially known as bovine spongiform encephalopathy, or BSE), scrapie in sheep, and vCJD in humans are thought to be caused by prions, misfolded versions of a normal cellular protein called PrPC.

Presumably, nucleophilic residues within a scrapie agent protein undergo carbethoxylation on reaction with diethyl pyrocarbonate, and subsequent addition of hydroxylamine displaces these carbethoxy groups.

In the US, consumer rights groups won a ban on the purchase of meat from scrapie flocks because no one could rule out absolutely the possibility of transmission to humans.

Several fatal neurological diseases — including Creutzfeldt - Jakob disease (CJD) in humans and scrapie in sheep — are marked by the accumulation of protein deposits in the brain.

She wonders if the animals actually contracted scrapie, another prion disease, because of lab contamination.

According to Richard Kimberlin, of the AFRC / MRC Neuropathogenesis Unit in Edinburgh: «The similarities are enough to make us think that it's in the scrapie family, but without evidence of transmission it's impossible to say anything more certain».

This turned out to be a normal protein in the cells of organisms throughout the animal kingdom — but in brains infected with scrapie and related diseases it turns up in both a normal, soluble form and an abnormal, insoluble form which accumulates in deposits that eventually kill the cells.

Scientists studying the commonest of the diseases in the group, scrapie in sheep, concluded decades ago that no virus or bacterium could be involved because infectious material appeared to contain no DNA.

The researchers then exposed these transgenic mice to prion isolates collected from sick animals, including classical and atypical strains of Bovine Spongiform Encephalopathy (i.e., mad cow disease), sheep Scrapie, and deer Chronic Wasting Disease.

In their study, the NIAID scientists injected infectious scrapie prion protein into the brains of mice.

But while the source of mad cow disease is fairly well established, no one knows how scrapie infects sheep.

It cause animal brains to turn into a spongy mess in scrapie, a disease of sheep, and in bovine spongiform encephalopathy (BSE or «mad cow disease»), as well as in human prion diseases such as CJD.

While the origins of BSE remain obscure, one possibility is that the cattle developed the disease by being fed meat and bone meal contaminated with prions from the sheep with the disease, scrapie.

The transmission of different scrapie prions in these mice also led to the propagation of prions that appear identical to those causing sCJD in humans.

The new finding offers direct, physical evidence supporting protein - based inheritance, thus strengthening the «prion hypothesis» of the cause of neurodegenerative diseases in mammals, such as sheep scrapie, mad cow disease (or bovine spongiform encephalopathy) and the kuru disease of the Papua New Guinea tribes.

It's almost impossible to get your hands on brain here because of the mad cow / scrapie scare.

And while kuru is of course a singular condition, its cousins — including mad cow and scrapie — are the stuff of everyday Western life, and it was for this discovery that he was awarded the Nobel Prize in Physiology or Medicine in 1976.

Dr. Cezar started her career at APHIS serving as a Veterinary Medical Officer, a role under Veterinary Services, where she worked firsthand in surveillance of critical public health diseases such as Chronic Wasting Disease and Scrapie.

Resistance of cattle to scrapie by the oral route.