The current crop
of seasonal flu vaccines, which contain H1N1, H3N2 and B flulike strains, are egg - based.
The Oneida County Health Department announced today that the demand for seasonal flu vaccine has been much higher than anticipated and that their supply
of seasonal flu vaccine was exhausted on October 9th.
The Health Department emphasizes that there is no shortage
of seasonal flu vaccine in Oneida County.
Novavax says that during Phase IIa
of seasonal flu vaccine testing, which began in May, it was able in the majority of people tested to surpass the FDA's requirements for producing enough antibodies to protect the body from the H3N2, H1N1 and B viruses — all of which were common enough a year ago to be used to develop flu vaccines for the 2008 to 2009 flu season.
Not exact matches
Apart from the nippy weather, many
of us start to notice change is in the air when the local chemist has started advertising
flu vaccines to prevent
seasonal influenza and more throats become scratchy and noses sniffly on our morning commute.
After its latest battle with H1N1, a U.S. Centers for Disease Control and Prevention committee recommended in February that everyone six months and older get the annual
vaccine, a step that should improve immunity against future pandemics as well as
seasonal cycles
of the
flu.
Widespread vaccination — which is why U.S. health officials are debating a nationwide swine
flu vaccination program that would mandate the creation
of 600 million immunizations, more than five times the 115 million
vaccines administered each year to battle the
seasonal flu.
The
vaccine's effectiveness suggests there must be pre-existing cell - mediated immunity, possibly because
of similarities between the surface proteins on swine
flu and the
seasonal H1N1
flu that emerged in 1977.
The company plans in October to conduct a separate test specifically to study the
seasonal flu vaccine's effectiveness among 480 elderly participants (a demographic often encouraged to get
seasonal flu shots), and Phase III efficacy trials across a larger set
of demographics are scheduled to begin early next year.
As the northern hemisphere braces itself for the
flu season, and for the first time the US recommends
flu vaccination for everyone over 6 months
of age, Australia has confirmed that its main
seasonal flu vaccine, Fluvax, caused convulsions in 99 children, all
of whom recovered.
With no head in place to hoard the immune response, the
vaccine might coax the body to make enough stem - focused antibodies to protect against
flu, the researchers hoped, regardless
of the
seasonal mutations occurring at the top.
Despite the limitations
of the
seasonal influenza
vaccine, people should still get their annual
flu shot, say the authors.
They were randomized to receive one
of three
vaccines: the quadrivalent
flu vaccine that contained two A
flu strains and both lineages
of the B strains; the licensed trivalent intradermal
vaccine for the 2012 - 2013
flu season; or an alternate trivalent intradermal
vaccine that contained two A strains and the B strain that was not in the licensed
seasonal flu vaccine.
The responses
of those given the quadrivalent
vaccine were the same as those
of volunteers who received the
vaccine with two strains
of A and the strain
of B that matched the B strain in the 2012 - 2013
seasonal flu trivalent
vaccine.
In addition to growth problems with the virus, Hall noted that one
vaccine maker is still making
seasonal flu vaccine and has yet to switch over to production
of the novel H1N1 product.
Although the world's attention is focused on the novel H1N1 virus causing the swine
flu pandemic, H3N2, a
seasonal strain
of influenza, has popped up in many East Asian countries — and some variants in circulation may outfox the
seasonal vaccine in use.
Currently,
seasonal flu vaccines are designed to induce high levels
of protective antibodies against hemagglutinin (HA), a protein found on the surface
of the influenza virus that enables the virus to enter a human cell and initiate infection.
If there is such sustained transmission, versus imported cases from people who traveled to areas where the virus is circulating, several decisions would need to be made, Hartl said, including whether to switch production from the
vaccine for
seasonal flu to the one for pandemic
flu, and whether to ramp up production
of antivirals.
«None
of them find any increase or decrease in the risk
of H1N1 disease associated with the
seasonal flu vaccine exposure,» she said.
The researchers then exposed some
of these strains to antibodies provoked by the current H3
seasonal -
flu vaccines.
Bruce Gellin, director
of the National
Vaccine Program Office, added that he has «high expectations» that the shots will work without adjuvants, as
seasonal flu vaccines do.
Researchers around the world, including at the University
of Rochester Medical Center (URMC), are pursuing a «universal»
flu vaccine, one that would protect against most or all
seasonal and pandemic strains
of the
flu virus.
Last week, the World Health organization reported that
vaccine companies have obtained yields
of the pandemic
vaccine that are 50 % to 75 % lower than those for
seasonal flu vaccine.
While this year's
vaccine is a much better match to the circulating
seasonal strains
of influenza, the shifty nature
of the virus and the need to pick the viruses used to make global
vaccine stocks well before the onset
of the
flu season can make
vaccine strain selection a shot in the dark.
Hensley and his team reported this egg - induced mutation, which was present in the 2016 — 17 U.S.
seasonal flu vaccine, decreases the ability
of certain antibodies to attach to and destroy the
flu virus — by a whopping three orders
of magnitude.
The finding is exciting «because it suggests that the
seasonal flu vaccine boosts antibody responses and may provide some measure
of protection against a new pandemic strain that could emerge from the avian population,» said senior study author Paul G. Thomas, PhD, an Associate Member in the Department
of Immunology at St. Jude.
Seasonal flu vaccines may protect individuals not only against the strains
of flu they contain but also against many additional types, according to a study published this week in mBio ®, the online open - access journal
of the American Society for Microbiology.
«
Seasonal flu vaccines boost immunity to many types
of flu viruses, research suggests.»
Each year, the U.S. Food and Drug Administration, in collaboration with the Centers for Disease Control and Prevention and the World Health Organization, decides which strains
of influenza virus to include in the
seasonal flu vaccine.