Sentences with phrase «of shifts over time»

This subject is complex, and the analyses even more complex, as it not only involves the direct science involved but the concept of variation, probabilities, and ranges (and types) of shifts over time.

Again, it's still early in the life cycle of both tablets and e-readers, and so we're going to see a lot of shifts over time as more groups find utility in these products.

Not exact matches

«As the economic tides change, the Bay Area, with its entrenched tech workforce, is the perfect place to take the pulse of worker expectations and how they are shifting over time,» Woo CEO Liran Kotzer told the Business Times.

By giving employees the ability to adapt over small day to day shifts in to - do lists, noise, and environmental needs, it also gives them a greater sense of autonomy when it's time to address larger concerns, like project ownership.

The nameplates of such titles as Time (b. 1923), Esquire (b. 1933), and Vogue (b. 1892) have been tweaked over the years to clarify their original purpose, even as the articles and artwork behind them shifted, at times dramatically.

It is also likely to shift over time, as affluence grows and technology evolves, and as companies like Coke and Starbucks and a thousand anonymous start - ups find new ways to make environmental protection efficient, in the broadest, most ethically - significant sense of the word.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

«There has been a shift over time in the role of the advisors and also in the fees paid to advisors,» Weir said.

In addition, we are also likely, over time, to see a shift towards the financing of personal loans, car loans and credit cards through securitised issues.

These bobbles do not rise to the level of statistical significance, of course, but over time small upward shifts can build into something meaningful.

As the chart below shows, exposure and weighting to any one type of security can and will shift over time in order to help you get the income you need.

Conversely, when the inclinations of investors shift from risk - aversion to speculation in an undervalued market, extraordinary returns can unfold over a very short period of time.

While risk does shift over time — technology stocks are less volatile than they were back in the late 1990s — most of the time the riskiness of an asset tends to move slowly.

And we track millions of their receipts — following the same consumers over time — so you can understand shifting tastes and trends.

Additionally, the classification of a sustainable investment strategy has shifted over time (think «sin stocks» versus ESG factors), making measurement and comparisons somewhat complicated.

Present indications are that overall growth of the economy is likely to remain strong, with the mix between domestic and external sources of growth shifting to a more sustainable position over time.

He started his career with Gold Fields at the St Helena Gold Mine as a graduate trainee and progressed via various operational roles from being an underground shift boss to become Vice President and Head of Operations at Kloof Gold Mine in January 1999 at which time Kloof produced over 1,000,000 ounces of gold per annum.

But there's a lot of research out there, and I think even Robert Shiller himself concedes that over time there could be some shift on what should be the equilibrium CAPE.

Household power — over children, spending, and daily decisions of all types — generally shifted to wives over time (and some women were happier overall as a result).

Even the employer share of increased premiums will mostly be shifted over time to employees via lower monetary compensation, as indicated by empirical studies.

Over this time, the business shifted more heavily towards Food products, which as noted above, made up 52 % of revenue in 2016.

In an effort to align manager's interests with shareholders, CEO compensation has shifted over time from cash salary and bonus to a mix with stock and options with vesting schedules where stock and options are now 55.6 % of the compensation1, with Earnings per Share (EPS) as one of the targets for vesting stock or options.

And over time as I myself have grown over the past five years, the blog has also kind of shifted so while that ruthless prioritization is still a major theme, I now also talk a lot about how that same concept applies to the way the way that you spend your time and energy.

«Roe v. Wade certainly did engage the pro-life movement by being so symbolic of an issue, but I don't think the level of opposition to abortion has really shifted that much over time,» Dimock said.

It is necessary to remember that such a paradigm shift does not occur overnight - paradigm shifts generally occur over a long period of time, with pockets of thought frequently unaffected by the new for a long period, and often with movement taking place back and forth between paradigms until the new paradigm becomes «settled» and existing social systems are reintegrated.

But a serious analysis of survey data over time provides little evidence that this fall's election cycle substantially shifted public opinion in favor of legal abortion.

Behind the tale's winsome glitter or lurid glare, there was always the outline of a sacred or demonic drama, however the sympathies of the poets may have shifted one way or another over time.

All the attention got McHargue interested in the idea of deconstruction — how beliefs can shift over time.

It stresses that «all peoples comprise a single community» and that from ancient times «there has existed among diverse peoples a certain perception of that hidden power which hovers over the course of things».21 Reference is made to the contemplation of the divine mystery in Hinduism and to Buddhism's acknowledgment of the «radical insufficiency of this shifting world».

Securing stability of the injection moulding process has been a challenge to the industry, especially as the parameters of the injection machine can shift over time.

When rolls are being changed, say, once every 20 minutes, as may be the case with pre-applied zipper film, that time adds up — over an hour and a half of production time lost in a single 8 - hour shift on a single line,» says Chris Graff, vice-president of sales and marketing at the Massachusetts - based Butler Automatic Inc. «That's an hour and a half's worth of packages not being made, shipped and sold from that line during each shift.»

players like Ozil always present the fans with a bit of a conundrum, especially when times are tough... if you look around the sporting world every once in awhile there emerges a player with incredible skill, like Ozil, Matt Sundin or even Jay Cutler, who have a different way about themselves... their movement seemed almost too lackadaisical, so much so that it seemed to suggest indifference or even disinterest on the part of the player... their posture always appears somewhat mopey and they generally have an unflattering «sour puss» expression on their face... for some their above average skills are enough to keep them squarely in the mix, as their respective teams try desperately to find a way to get the best out of them visa vie player acquisitions or the reworking of tactics... when things go according to planned the fans usually find a way to accept their unique disposition, whereas when things go awry they become easy targets for fans and pundits alike... in the case of Ozil and Sundin, their successes on the international stage and / or with their former teams led many to conclude that if we surrounded such talented individuals with players that have those skills that would most likely bring the best of these players success would surely follow... unfortunately both the Maple Leafs and our club chose to adopt half - measures, as each were being run by corporations who valued profitability over providing the best possible product on the field... for them, they cared more about shirt sales and season tickets than doing whatever was necessary... this isn't, by any stretch, an attempt to absolve Ozil of any responsibility for his failures on the pitch... there is no doubt oftentimes his efforts were underwhelming, to say the least, but this club has been inept when it comes to providing this prolific passer with the kind of players necessary for him to flourish... with our poor man's version of Benzema up front, the headless chickens in Walcott, the younger Ox and Welbeck occupying wide positions far too often and the fact that Carzola, who provided Ozil with great service and more freedom to roam, was never truly replaced, the only real skilled outlet on the pitch was Sanchez... remember to be considered a world - class set - up man goals need to be scored and for much of his time here he has been surrounded by some incredibly inept finishers... in the end, I'm not sure how long he will be in North London, recent sentiments and his present contract situation seem to suggest that he will depart at season's end, but how tragic would it be if once again we didn't put our best foot forward and failed to make those moves that could have brought championship football back to our once beloved club... so when you think about this uniquely skilled player don't be so quick to shift all the blame on his shoulders because he will not be the first or the last highly skilled player to find disappointment at the Emirates if we don't rid the club of those individuals that are truly to blame for our current woes

like I've said before, Wenger is simply stating that Sanchez is staying so that he can regain some leverage when it comes time to make a deal and to shift the focus back squarely on Sanchez... this is 101 tactics in PR management... the very fact that he even mentioned RVP's name speaks to the utterance arrogance of a man that believes he answers to no one... before you harshly judge Sanchez think carefully about what the ultimate intentions of both parties involved... Sanchez wants to win trophies and get paid generously for his efforts, whereas the club wants to pull the wool over our eyes once again so that we blame the player for wanting the very things we told him we wanted when we brought him in... how many times do we have to go down this road before we realize the only common factor in each of these scenarios is the club itself... trust me, if we showed any ambition Sanchez's contract demands would be much different... just like in other major sports players will take a «home town» discount if they see those in charge making a truly honest attempt to fight for the highest honours in their respective fields... that being said, if they see a team trying to make disparaging remarks about them in the press and not following through on their promises, they will likely try to make them pay a premium for their services or seek greener pastures... btw if anyone simply looks at the score versus Bayern today and thinks that even for a second that this was a deserved victory, just watch the game and judge for yourself... actually save yourself the anguish and just know that if it weren't for Cech and Martinez this could have been a repeat of our Champions League flopping or worse

Wenger himself admitted that he had been pondering over shifting to a back - three for quite some time now and it looks like the signing of Kolasinac has been made with the new system in mind, considering that the Bosnian is a quick and powerful full - back who can also play as a centre - half and as a holding midfielder.

Besides the 2013 University of Washington study, a number of other recent studies have found education ineffective in improving self - reporting by athletes, adding to a growing body of evidence challenging the conventional wisdom that inadequate athlete concussion knowledge is the principal barrier to increased reporting, and suggesting that one of the best ways to combat underreporting by athletes of concussion symptoms may be to shift the focus of educational efforts towards helping coaches facilitate concussion reporting, the theory being that athletes will be more likely to report concussion symptoms if they no longer think that they will be punished by the coach for reporting, such as by losing playing time or their starting position, perceived by their teammates as letting them down, or viewed by their coach as «weak,» all of which have been documented in numerous studies over the past decade as reasons athletes are reluctant to report concussion symptoms.

In other words, we have to be able to sprint several times a game for short bursts (think 30 - 45 second shifts) and do it over the course of a long period of time (e.g. a 60 minute game).

Number and length of naps will shift over time, and bedtime will change.

Husbands whose wives make more money are 61 % less likely to say they're happy Wives who are primary breadwinners are also significantly less happy about their family lives than other women Men are 5 times more likely to cheat when they're financially dependent on their wives Divorce is 40 % more likely when a women makes over 60 % of the family's income Much of the discussion around this topic so far has focused on the broader business and economic consequences of this shift.

Over time, the growth of the baby inside you causes your center of gravity to shift forward.

Sucking on the nipple can, over time, cause the position of teeth to shift in the gums.

But, for the first week she was home we had her sleeping round the clock (she was slightly premature, so a very sleepy baby) in the pack and play in our living room, with one of us awake and keeping vigil over her at all times, taking shifts!

It's a series of predictions and musings more than a single argument, since he starts with the idea that digital tools tend, over time, to shift power away from large institutions and toward small groups and individual actors and goes on to think about how it will affect institutions across the board.

Individual biographies are important because they provide insights into people's understandings of themselves and «the state», help us to appreciate how these understandings shift over time and space, and enable us to explore the role that involvement in grassroots politics plays in those shifts.

Nicco's book is a series of predictions and musings more than a single argument, since he starts with the idea that digital tools tend, over time, to shift power away from large institutions and toward small groups and individual actors and goes on to think about how it will affect institutions across the board.

English does serve as a kind of de facto lingua franca in a number of international settings, but it is not, from what I have read, taught universally in South America, many African countries, or in parts of Asia, at least not at an early age for effective language acquisition (and I am unaware of any evidence that English is projected to take over in a reasonable period of time on its own; I have read that in Southeast Asia, for example, emphasis may even be shifting to Chinese).

The Democratic and Republican points of view tend to shift and change over time.

«A sharp, permanent increase in taxes on a small group of highly mobile taxpayers, who enjoy a great deal of discretion over the timing and nature of their income, will inevitably cause some of them to either shift income away from this jurisdiction, or earn less, or collect the income in forms that will not be taxed,» said E.J. McMahon on the fiscally conservative Manhattan Institute.

We need to make sure that we are in control over the things that affects us.Anytime there is flood and people loose their life, most of the blame goes to sitting presidents.I am not saying that the central government does not have responsibility to ensure that enabling environment is created.They have a great work to do but as citizens what is our quota?When you move around Accra, sometimes i becomes angry within myself because i am in doubt as to whether our sanitation laws exit.People because of the tax they claim they pay waits for zoom lion workers to come and clean the choked gutters before our houses and shops either than that, it will remain like that.Is it modernity or civilization that has turned us to forget our traditional values or duties of ensuring that our environments is clean?Everybody in our Ghanaian setting knows the responsibility of men and women in making sure that our environments are clean not waiting for flood to occur and we start blaming sitting presidents.To the media, though your responsibility is to keep governments on it toes, you equally have a mandate in educating the public of what we are expected to do as citizens in other to ensure that our dear nation is a better ecosystem for all of us to live.The attention of the media should be shifted from making politicians popular to making us aware as citizens of our responsibilities.I sometimes get confused to hear journalists calling opponents to comment on issues concerning the sitting governments and the only thing that comes to my mind is what do the journalist want to hear from the political opponents?Nothing.They will end up criticizing without giving an alternative.The media should rather resort in questioning people directly to where the problems are coming from.Let us build our institutions.When it comes to energy issues.Citifm will call Hon.KT Hammond who was a deputy minister living who he worked under (His boss at that time) and I always become confused because what can we expect from him?nothing.

If he's accused of stealing money every time he worked day shifts simultaneously for the city and state over those three years, the total amount he made from the state would be $ 32,550, according to the records.

Over time, however, the emphasis shifted away from preparing future scientists and strongly toward performing federally funded grant research using the labor of trainees.