Sentences with phrase «of sialic»

[5] Varki A, Gagneux P. Multifarious roles of sialic acids in immunity.

One of the sialic acid - containing molecules gliadin binds to is called GM1 ganglioside.

The cellular localization of the polymers was confirmed by subcellular fractionation of the cells, followed by digestion with endoglycosidase H (Figure 2C and Supplemental Figure 3C), an enzyme that removes N - linked glycans still in the high mannose ER form but does not affect oligosaccharide chains after the addition of sialic acid in the Golgi apparatus.

Without adequate supplies of sialic acid, progressive muscle degeneration (or myopathy) sets in.

Oral administration of the sialic acid precursor N - acetyl - mannosamine (ManNAc) partially rescues the kidney defect, allowing the mutant mice to survive.

Her research focuses on disorders of sialic acid metabolism and of lysosome - related organelles.

Since the attachment of sialic acid to an Fc group requires the presence of another glycan called galactose, the team created two enzymes termed B4Fc and ST6Fc, which induce the attachment of galactose and sialic acid respectively.

The positive effect of sialic acid Neu5Gc on the respiratory system was confirmed using a mouse - model: The Neu5Gc molecules consumed with food improved the pulmonary function of the mice, therefore reducing asthma symptoms.

«We discovered that Neu1, a protein nicknamed after «neuraminidase 1,» turns the absorption of sugar «on» or «off» in body cells, by regulating the amount of sialic acid on the surface of cells,» Dr. Pshezhetsky explains.

Not exact matches

These modules recognise a specific sugar molecule, sialic acid, which caps the end of mucin glycan chains.

They can absorb sialic acid through contact with animals or by eating food of animal origin and integrate it into their glycoproteins.

If we can remove sialic acid residues from the cell surface, this will force the insulin receptor do its job of absorbing blood sugar properly.

Some of these sugars, called sialic acids, help tumors hide from the immune system.

Wilson's laboratory used X-ray crystallography to determine the atomic structures of the H7N9 hemagglutinin protein bound to these sialic acid receptor molecules.

In previous work, Anthony's group and others have found that the anti-inflammatory effect of high - dose IVIG can be attributed to a minor fraction of antibodies to which a glycan called sialic acid has been attached to their Fc region.

The treatment consists of providing N - acetylmannosamine, which forms sialic acid in the body.

[MR: This is because lack of Neu1 means that it's not available to strip sialic acids from LAMP - 1, and oversialylated LAMP - 1 leads to loss of its inhibitory function over lyso exocytosis, apparently leading to a nonspecific puking out of its contents into the ECF].

Sialic acid synthesis is tightly regulated; defects in this pathway cause a variety of disorders, including hereditary inclusion body myopathy (HIBM), sialuria, infantile sialic acid storage disease (ISSD), and Salla diSialic acid synthesis is tightly regulated; defects in this pathway cause a variety of disorders, including hereditary inclusion body myopathy (HIBM), sialuria, infantile sialic acid storage disease (ISSD), and Salla disialic acid storage disease (ISSD), and Salla disease.

Neu5Gc is the glycolyl capped sialic acid that is found on the cell surfaces of all mammals except humans, who lost the gene for the enzyme to oxidize the acetyl version.

Human milk oligosaccharides (HMO) are a mixture of indigestible oligosaccharides composed of glucose, galactose, fucose, sialic acid and N - acetyl - glucosamine [1].

Presumably free sialic acid is made available to such pathogens by other, sialidase - expressing bacteria living in the same niche, or... by host sialidases that are activated in the course of inflammation.

To date, the published research on this topic has focused on the possibility of pathogens incorporating Neu5Ac, the primary human sialic acid, from human cells into their cell walls, and subsequently triggering autoimmunity against Neu5Ac.