Not exact matches
The binding
of a BRAF mutation to the ER stress gatekeeper GRP78 is a new and unexpected molecular interaction driving resistance, and establishes a new
signaling axis that has multiple drug targets, Dr. Amaravadi said.
«This study defines a
signaling axis that is essential for head and neck cancer progression, and our findings show that this
axis may be disrupted at three key steps,» says principal investigator Quintin Pan, PhD, associate professor
of otolaryngology at the OSUCCC — James.
The strength
of the
signal also varied over hours, weeks and months, because
of the water vapor plumes rotating in and out
of Herschel's views as the object spun on its
axis.
Whereas most chiroptical effects result from a response
of bound electrons, photoionization can produce much stronger chiral
signals that manifest as asymmetries in the angular distribution
of the photoelectrons along the light - propagation
axis.
But now mission controllers must «focus on new classes
of science,» the most exciting
of which is using Spirit's radio
signal to track the motion
of Mars both in its orbit and in its spin on its
axis.
The result
of this collision was what is known as the Variscan orogeny, the raising
of a mountain range along the North - South
axis, which left the rocks with a secondary magnetic
signal, adapted to the new magnetic field
of the Earth.
Inhibition
of cell migration and invasion
of enzalutamide - resistant prostate cancer cells was effected by niclosamide through its effects on the androgen receptor (AR)- STAT3
signaling axis [40].
Diverse
signaling pathways through the SDF - 1 / CXCR4 chemokine
axis in prostate cancer cell lines leads to altered patterns
of cytokine secretion and angiogenesis.
Central hypothalamic insulin
signaling interfered with negative feedback to the hypothalamus - pituitary - adrenal (HPA)
axis in stressed male mice (151), which potentially explains high comorbidity rates
of mental and metabolic disorders (see section V.P).
The co-incidence
of these 2 pathologies occurs also in humans suggesting a common pathological mechanism moving across the gut - joint
axis, with TNF
signals acting on specific cell types directing pathogenesis at two different locations.
Prof. George P Chrousos is internationally recognized for his research on the glucocorticoid
signaling system
of the cell, on the diseases
of the hypothalamic - pituitary - adrenal
axis, and on the physiological and molecular mechanisms
of stress.
A complex set
of interactions between morphogens and their corresponding
signalling pathways contributes to organizing limb growth along the dorsal - ventral, anterior - posterior and proximal - distal
axes.
Joint NOD2 / RIPK2
signaling regulates IL - 17
axis and contributes to the development
of experimental arthritis
Ongoing projects aim to define the involvement
of these two
signalling axes in cancer and to investigate whether the endocytic function
of Numb is relevant to its tumour suppressor function.
For instance, the role
of LIF - gp130 - Stat3
axis in promoting ES cell proliferation is particularly well - defined [1], [3], and BMP - induced differentiation
signals are inhibited by a Nanog - Smad1 protein complex [4]; crosstalk between these pathways has also been reported [5].
Interaction between the human host and its's microbiome is mediated via several
axes of communication including the immune system,
signalling and direct metabolic cross-talk that physiologically connect the gut with the brain, muscle and liver.
In liver, FGF21 inhibits the GH
signaling pathway... Thus, FGF21 - mediated repression
of the GH / IGF -1
axis provides a mechanism for blocking growth and conserving energy under starvation conditions.
The HPA
axis is composed
of the two regulatory control centers in the brain: the hypothalamus and pituitary gland, which secrete stimulatory neurotransmitters that
signal the adrenal glands to produce cortisol, the body's main anti-stress hormone.
The Hypothalamic - Pituitary - Adrenal (HPA)
axis is a feedback loop by which
signals from the brain trigger the release
of hormones, such as cortisol, needed to respond to stress.
The HPA
axis relies on a series
of hormonal
signals to keep the sympathetic nervous system — the «gas pedal» — pressed down.
The term «microbiota - gut - brain
axis» is used to describe the complex bidirectional
signaling that occurs between the GI tract and the nervous system, and emphasizes the newly recognized role
of intestinal microbes in these interactions.
The first thing that seers itself into your line
of vision are the 12 panel paintings by Rochelle Feinstein which began in 2008 to mark American - led invasions
of the Middle East and the halftone dots forming the outline
of globes that seem to be turning on a wobbly
axis embody the various definitions
of the word «hotspots» as a Wi - Fi
signal location, a jumping night spot, central hotbed
of activity, etc..
An emerging body
of literature24, 25 shows that a subgroup
of chronically aggressive children exhibit marked difficulty processing social cues that
signal the need to inhibit aggressive impulses.26 These findings have been attributed to reduced responding in specific neural architecture associated with stress responses and HPA
axis regulation.