Sentences with phrase «of signaling proteins»

First, dietary phosphorus can influence the production of bone by helping with phosphorylation — a chemical process by which phosphorus is linked to an amino acid — of signaling proteins that stimulate bone growth.

Phosphorylation of signaling proteins was investigated using the following phospho - specific antibodies from Cell Signaling Technology: anti-pY1034 / 1035 JAK1 (# 3331S), anti-pY1007 / 1008 JAK2 (# 3771S), anti-pY705 STAT3 (# 9131S), anti-pY694 STAT5 (# 9351S) and anti-p44 / 42 MAPK (# 9101L).

«It has been an organizing principle for the field that these mutations trigger cancer by interfering with the on - off switch of these signaling proteins, but our study adds a big wrinkle: these mutations can also keep the enzyme on when the switch is turned off,» Shokat said.

«One exciting thing about this finding is that the GDP - bound form of these signaling proteins is typically much easier to target with a drug,» Shokat said.

This revealed networks of signaling proteins that are partitioned into the PD and / or the CB compartments.

Using cell culture assays and genetically modified mice, we identified a number of signaling proteins that participate in muscle plasticity.

Second, NK cells churn out many different forms of signaling proteins, which can promote or suppress inflammation by aiding in recruitment and activation of other immune cells.

In the course of seeking new treatments for brucellosis, scientists discovered that Brucella contains a class of signaling proteins called LOVs.

The ROBO family of signaling proteins — best known for their role in guiding the growth of developing neurons — regulates the cytoskeleton, and may therefore help cells sense and respond to such changes in their environment.

«It's long been my hunch that the earliest events in left - right asymmetry involve a shunting [of signaling proteins such as ZIC3] to one side or the other, and it's certainly appealing to invoke dyneins and the cytoskeleton to help with that,» says Casey.

To confirm this synergistic effect, the team measured serum levels of signaling proteins in tumor - bearing mice receiving OX40 agonist antibodies alone or in combination with GSK2636771.

When attractant or repellant chemicals attach themselves to receptor sites on the surface membrane of a bacterium, it triggers a process within the cell that leads to the modification of the signal protein, CheY (pronounced «Key - Y»), enabling it to bind to the switch and change the bacteria's direction of movement.

These studies showed that inhibiting the activity of the signaling protein MEK was essential for these tumors to grow.

As seen through a microscope, the leg bone of a normal mouse (left) makes considerably less new bone than a mouse that produces high levels of a signaling protein, WNT7B, that stimulates new bone growth (shown in pink on the right).

In mice containing transplanted human cells carrying about 310 GAA repeats, the prosthesis restored expression of a signaling protein to nearly normal.

FOP is caused by overactivation of a signaling protein involved in embryo development, BMP.

Not exact matches

Immunotherapy differs from more traditional cancer treatments, such as surgery (cutting malignant cells out of the body), chemotherapy and radiation (poisoning the deadly mutants), and even the newer, more precise molecular drugs that attempt to jam the protein signals that tell tumor cells to keep dividing and conquering.

Farnfield MM, Breen L, Carey KA, Garnham A, Cameron - Smith D. Activation of motor signaling in young and old human skeletal muscle in response to combined resistance exercise and whey protein ingestion.

That's because TRPV1 receptors — proteins on nerve endings that detect heat — are activated by capsaicin, and erroneously interpret capsaicin as a signal of extreme heat, Live Science reported previously.

A study conducted by the Harvard School of Public Health, highlighted that women who ate 16 or more strawberries per week, were 14 % less likely to have elevated levels of C - reactive protein, a blood biomarker that signals the presence of inflammation in the body.

«This new study shows a dramatic switching on of the insulin receptor and its downstream signals during the breast's transition to a biofactory that manufactures massive amounts of proteins, fats and carbohydrates for nourishing the newborn baby,» says Dr. Nommsen - Rivers.

Once there, the protein acts on the osteoblasts and inhibits Wnt activity, which is a cellular signalling pathway that is involved in the formation of the skeleton and in certain disorders, such as osteoporosis, arthritis and myeloma.

But to coax them down a specific path in the lab requires recreating the precise sequence and timing of environmental cues in the womb — the signals from proteins and hormones that tell cells what kind of tissue to become.

Chronic pain may be due to an overabundance of a protein, which amplifies the pain signal to the brain.

Taking a closer look, the team found that the onset of sepsis disrupts the normal activity of specific interferons, signaling proteins used for communication between immune system cells.

Further study revealed that these so - called immune proteins are actually present on the surface of certain nerve cells, but that they functioned differently in the brain than they did in the rest of the body; rather than scouting for germs, they influenced signals sent between neurons.

If a biomolecule of interest were tagged with the GFP gene, Prasher thought, a fluorescent signal would show when and where in the organism that gene or the protein it created was being put to use.

The protein is an essential constituent of the visual cycle that converts light to electrical signals to the brain.

Within the framework of research projects of the German Center for Diabetes Research (DZD), scientists of the Research Unit Protein Science (PROT) and the Institute of Experimental Genetics (IEG) at Helmholtz Zentrum München (HMGU) have now investigated how drug treatment affects these signal carriers.

In an additional group of endometriosis samples biopsied from 15 women at the University of British Columbia, the scientists looked specifically for mutations in the KRAS gene, whose expression signals proteins that spur cell growth and replication.

Sasha De Henau, a researcher at the Biology Department of Ghent University in Belgium recently discovered a globin protein in the roundworm model Caenorhabditis elegans that is able to generate such free radical signals.

Using small - molecule inhibitors to eliminate the activity of the proteins produced by the bird - specific, median signaling zone in chicken embryos, the researchers were able to induce the ancestral molecular activity and the ancestral anatomy.

Gloria Coruzzi and her colleagues at New York University and the Chinese University of Hong Kong suspected that these toxins may also be part of plant signaling system, and so they set out to see if plants had proteins like glutamate receptors.

Ixekizumab is a monoclonal antibody - a cloned antibody - which neutralises the inflammatory effects of an interleukin (IL) a protein in the skin which carries signals to cells - known as (IL)-17 A.

And research spun out of neuroscientist Linda Watkins's group at the University of Colorado in Boulder is testing a new pain drug that may tame glia in the spinal cord by blocking a signaling protein on their surface.

Weissman's research in mice had revealed that cancer cells produce large quantities of CD47, a protein that signals immune cells to spare the cancer cells.

The exceptional cancer cells that escape the astrocytes do so by producing a protein called Serpin, which acts as a sort of antidote to the death signals fired at them by nearby astrocytes.

The vast majority of the thousands of potential membrane protein - signaling protein interactions they found had never before been identified.

«In the case of glycoprotein hormone receptors, the family of proteins that includes the thyroid receptor, upon binding of the extracellular hormone, the intramolecular activator (p10) induces structural changes of the receptor protein, triggering activation of the intracellular signaling cascade.»

The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast.

The researchers found that, in response to the maximum tolerated doses of several commonly used chemotherapy drugs, breast cancer - associated fibroblasts secrete large amounts of cell signaling proteins called ELR + chemokines.

Previous studies have shown that such vulnerability can lead to more frequent anxiety, and anxiety is known to activate a metabolic pathway responsible for the production of pro-inflammatory cytokines, signaling proteins that include interleukin - 6 (IL - 6).

In research that has implications for diabetes and other metabolic diseases, an international study based at UT Southwestern Medical Center found that the protein connexin 43 (Cx43) forms cell - to - cell communication channels on the surface of emerging beige fat cells that amplify the signals from those few nerve fibers.

The circuit Hasan's group has discovered consists of three types of nerve cells — one set senses and reports the lack of protein in food, a second set integrates this input with metabolic information and the third set controls the hormonal signals necessary to begin pupation.

King hypothesizes that proteins that the single - celled ancestors of animals used to interact with the extracellular environment — to capture bacterial prey by binding to their cell surface and to detect chemical signals — were later repurposed to enable cells to stick to and talk to each other.

They showed that ZIKV infection of cortical progenitors (stem cells for cortical neurons) controlling neurogenesis triggers a stress in the endoplasmic reticulum (where some of the cellular proteins and lipids are synthetized) in the embryonic brain, inducing signals in response to incorrect protein con - formation (referred to as «unfolded protein response»).

Twenty vials of his blood helped tell the story: Dangerously low blood platelets suggested an underlying imbalance, and signature proteins signaled some type of autoimmunity at the root.

University of Washington researchers have found that a calorie - restricted diet reduces the activity of a cell - signaling protein called TOR - 1 that may speed up cell aging.

By analyzing chemical changes of the IRS - 2 protein in immortalized cultures of human white blood cells, it determined that IRS - 2 appeared in two different forms — «on,» which allows the signal to pass through, and «off,» which stops the signal from activating the cells into M2 macrophages.

The research team, including Soumen Paul, Ph.D., associate professor, Arindam Paul, Ph.D., assistant professor, and Ossama Tawfik, professor, M.D., Ph. D., all in the Department of Pathology and Laboratory Medicine, and their colleagues, studied atypical protein kinase c lambda / iota signaling during the invasive progression of triple - negative breast cancer.