Sentences with phrase «of single brain cells»

Rose and neuroscience doctoral student Rishi Alluri used a novel combination of recording electrical activity of single brain cells and blocking neurotransmitter chemicals that carry nerve signals from one nerve cell or neuron to the next.

Not exact matches

We can not stay where we are at present, either physically or psychically; but looking far ahead we may descry an ultimate state in which, organically associated with one another (more closely than the cells of a single brain) we shall form m our entirety a single system, ultra-complex and, in consequence, ultra-centrated....

Blakemore argues that a single gene mutation could in fact have been the cause of this increase - for in fact only one extra cell - division step would cause a doubling of brain size.

Scientists have discovered why a single mutated protein can lead to serious mental retardation in men with a common genetic disorder called fragile - X syndrome: The healthy protein is essential for establishing during childhood the adult pattern of connections between nerve cells in the brain.

A study analyzing brain tumor genomics on a single - cell level has found evidence that cancer stem cells fuel the growth of oligodendrogliomas, a slow - growing but incurable form of brain cancer.

The team asked the patients to categorize a variety of images as fast as possible while their electrodes recorded the firing of nearly 1,500 single brain cells across the group in real time.

These insights about brain waves coincide with a shift in neuroscience away from a view that reduces the brain down to the behavior of single nerve cells, or neurons.

The findings, published online this week by the Proceedings of the National Academy of Sciences, provide the strongest evidence to date in support of the notion that sex chromosomes acting on single cells play a role in differences between male and female brains.

He thought creating a light - sensitive brain was probably impossible, but then an idea floated up: What about tapping the power of light - sensitive microbes, single - celled creatures that drift in water, turning toward or away from the sun to regulate energy intake?

The findings, published Sept. 20 in the Journal of Virology published by the American Society for Microbiology, were publicly revealed almost simultaneously with those from China - based scientists who found a change of a single amino acid made the virus more dangerous to developing brain cells.

A team of multidisciplinary researchers with expertise spanning biotechnology, information technology, and medicine have used a combination of several «omics technologies to map proteins down to the single cell level, showing both proteins restricted to certain tissues — such as the brain, heart, or liver — and those present in all tissues.

Glioblastoma is the most lethal form of primary brain tumor and leads to death in patients by invading the brain tissue in a process that allows single cells to move through normal brain tissue, which makes complete surgical removal of the tumor impossible.

When the scientists recently gave mice a single dose of cocaine and looked for signs of autophagy in their brain cells, they detected autophagy - associated proteins and changes in vacuoles in adults and in mouse pups whose mothers had received cocaine while pregnant.

«In the past it was deemed technically impossible to follow single cell stem cells in the brain over time given the deep localization of the hippocampus in the brain,» said Jessberger.

By interfacing brain cells onto graphene, researchers at the University of Illinois at Chicago have shown they can differentiate a single hyperactive cancerous cell from a normal cell, pointing the way to developing a simple, noninvasive tool for early cancer diagnosis.

In a famous set of experiments in human subjects in 2005, neuroscientist Rodrigo Quian Quiroga found that pictures of actor Jennifer Aniston activated a single brain cell in the hippocampus region — the so - called Jennifer Aniston neuron.

But postpartum depression can't be pinned to any single substance or brain malfunction — it doesn't reside in one tidy nest of brain cells, or any one chemical process gone haywire.

At a symposium at The American Society of Human Genetics here last month, they reported zooming in on the genes expressed in a single brain cell, as well as panning out to understand how genes foster connections among far - flung brain regions.

However, the signals of individual brain cells can be noisy and imprecise — which means our brains can not rely solely on the activity of single neurons to make accurate decisions about our world.

The team used this change in the variability of the song to look at how the activity of single cells in different parts of the brain altered their activity depending on the social environment.

The scientists used the new indexing method on several human cell lines and from a mouse brain to reveal the methylome of 3,282 single cells.

Of course, bacteria are single - celled organisms and don't have brains, he said.

«Nature, meet nurture: Single - cell analysis reveals diverse landscape of genetic changes in the brain after a sensory experience.»

In healthy people, brain cells link together at a single frequency of electrical activity, like tuning in to a radio station, says Robert McCarley of the VA Boston Healthcare System and Harvard University.

In their new Science paper, the researchers analyzed gene expression in single cells across key developmental time points and from different regions of the brain.

Now researchers reporting in the Cell Press journal Neuron on July 18 show in a study conducted in rats that even a single exposure to nicotine temporarily changes how the brain's reward system responds to alcohol and increases the reinforcing properties of alcohol via stress hormones.

«We were able to develop this very novel method to go to a single neuron and manipulate how it computes» by using drugs to block neurotransmitters at the level of a single nerve cell in a frog brain, and then measuring what happens to that neuron in response to frog calls, Alluri says.

Scientists seeking to understand the neural mechanisms underlying social cognition and emotion have drawn on a variety of methods, including studies of patients with neurological damage and single - cell recording of brain activity in nonhuman animals.

The new study combined two methods: So - called «patch recording» of tiny voltages in single frog brain cells and how the voltages change in response to sounds of different lengths, and the administration of drugs that block neurotransmitters — a way to learn how brain cells respond to sound with and without the normal neurotransmitters.

But these imaging data are represented in completely different formats, and there's no way to switch between the two: once scientists zoom in to the level of single cells, they can not pan out again to see those cells in the context of the whole brain.

Korenberg's team is developing a 3D coordinate system to align various types of neuroimaging data in the macaque brain, from whole - brain MRI connectivity to single - cell confocal data and, for some areas, subcellular resolution with electron microscopy.

Caltech biologists work to reveal nature's mechanisms — how tens of thousands of components act in concert in cells, how organisms grow from single cells, how the brain maintains its consciousness, emotions, and superb computational capabilities, and what happens when any of those processes goes awry.

I think many people, including leading physiologists, thought that it was just not going to be possible to show correlates of activity at the single cell level in brain areas that were so far away from the periphery.

For example, the BRAIN Initiative supports a series of projects that are characterizing mammalian brain cell types using single - cell genomic analBRAIN Initiative supports a series of projects that are characterizing mammalian brain cell types using single - cell genomic analbrain cell types using single - cell genomic analysis.

In contrast to mouse vRGs, which produce 10 to 100 daughter cells during brain development, a single human oRG can produce thousands of daughter neurons, as well as glial cells — non-neuronal brain cells increasingly recognized as being responsible for a broad array of maintenance functions in the brain.

Ultimately, the combination of this new method of focusing on gene activity in single cells with other single - cell techniques involving microscopic imaging is likely to reveal the origins of developmental disorders of the brain, he added.

On the plane, I read a couple of applications centered on nanoscience, where tiny tubes are etched into silicon wafers to get substances into the brain or outside of the brain, or even to have better access to single cells and to get substances in and out of cells.

Their image, showing six different computational visualizations of a cell membrane for a single brain cell, was featured as the cover story in a special issue of Biophysical Journal, that focuses on brain biophysics and is published by the Biophysical Society.

The pharmacokinetic properties of J147 after a single dose of 20 mg / kg in mice show brain levels of about 600 nM at 2 h, over 10-fold above its EC50 in some cell culture neuroprotection assays [7], with a brain to blood ratio of approximately 0.5.

The goal of this work is to characterize the role of dendrites in learning and memory processes so as to formulate a unifying theory regarding their contribution in memory formation across brain regions and abstraction levels.This will be achieved via the development of computational models that start at the single cell level and expand to the microcircuit and the network level, while varying in their degree of biophysical detail.

Albertin is interested in the way octopuses develop from single cells to fully - fledged hatchlings, and fellow study author Yan Wang, also of the University of Chicago, told The Post she'd be studying how the octopus brain controls complex behavior, especially in relation to mating and reproduction.

Towards this goal, we build abstract mathematical as well as detailed biophysical models of neural cells and circuits across multiple brain regions (hippocampus, amygdala, PFC) and abstraction levels (single neurons, microcircuits, neuronal networks).

We are using a new technique, called single cell RNA sequencing, to isolate thousands of single neurons from human brain tissue, study all the genes that are expressed in each individual cell, and make cell - to - cell comparisons between normal, early stage and late stage AD.

Mice with a single insult temporarily lose 10 - 15 percent of the neuronal connections in their brains, but no inflammation or cell death resulted.

Production of a Quality Control Pipeline for Single Nuclei RNA - seq and Its Application in the Analysis of Cell Type Diversity of Post-Mortem Human Brain Neocortex

I was lucky to join the lab of Dr. Christine Holt at the University of California, San Diego in 1993, to continue my research training, trying to understand at a single cell level how the retinal cells of the eye connect with brain.

Three recent experimental studies focused on low consumption / exposure.949596 In one study, 29 smokers each consumed a single cigarette, immediately after which they had a significant decrease in blood vessel output power and significant increase in blood vessel ageing level and remaining blood volume 25 minutes later, as markers of atherosclerosis.94 In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.96

Microinjection of membrane - impermeable molecules into single neural stem cells in brain tissue.

Researchers at the Howard Hughes Medical Institute's Janelia Research Campus have uncovered unexpected diversity within a single, canonical cell type of the mammalian brain.

SAN FRANCISCO, CA — June 7, 2012 — Scientists at the Gladstone Institutes have for the first time transformed skin cells — with a single genetic factor — into cells that develop on their own into an interconnected, functional network of brain cells.