Sentences with phrase «of single genes»

The recent Nobel Prize winner explains how the technology of studying the effects of single genes has revolutionized the study of mammalian biology of human medicine.

Such models aim to elucidate the contribution of single genes for protection against mutations, genomic instability, ageing and ageing related diseases such as cancer.

Gene targeting makes it possible to study the effects of single genes, including those that don't occur naturally in mice.

Conditional expression of hairpin constructs in Drosophila is a powerful method to disrupt the activity of single genes with a spatial and temporal resolution that is impossible, or exceedingly difficult, using classical genetic methods.

Instead of the simple manipulation of single genes, he wants to engineer many genes to work together, like transistors wired in a circuit.

The study, published in Nature Genetics, offers the possibility that targeting these processes, instead of single genes, may provide new opportunities for treatment of Wilms tumor.

«For species that have a very rapidly changing environment, this process of co-option of single genes may be fairly important.

With the data provided by the FLI researchers, scientists around the world may now set targeted mutations to investigate the relevance of single genes for aging, in order to better understand regulating mechanisms and, eventually, develop new approaches for therapy or prevention of aging - related diseases.

That is easy to explain by a feature that we now recognize as universal: the plasticity of expression of single genes.

Teasing out the effect of single genes in deafness is difficult.

Here's why: In the late 90s, technology emerged enabling researchers to rapidly sequence RNA and DNA — giving them the ability to isolate and record the activity of single genes.

An article in New Scientist (12 May 2012) explored the fact that a double mutation of a single gene seems to have taken place about 2.5 million years ago, beginning the separation of homo from Australopithecus.

They asked the question, What controls the activity of a single gene, turning it on or off?

In yeast, for example, they've found that increasing the activity of a single gene, called Sir2, can significantly extend life span.

In 1993 she proved that turning down the expression of a single gene, daf - 2, through genetic engineering doubled the worm's life span.

The loss of a single gene in mice can affect social behavior and impair their brains» ability to filter out distractions — both characteristics of several neurological diseases in humans.

The results of the study were obtained by infecting laboratory - grown cells with forms of the CMV virus which differed only by the removal of a single gene.

Cystic fibrosis, achondroplasia, phenylketonuria and Huntington's disease are each caused by simple changes in the sequence of a single gene.

According to study co-author Larry J. Young of Emory University, the results provide evidence in a comparatively simple animal model that changes in the activity of a single gene profoundly can change a fundamental social behavior of animals within a species.

That pattern of inheritance would suggest the strong effect of a single gene mutation, and it would most likely crop up in families that had a lot of shared genes through the intermarriage of first cousins.

«To our knowledge, our model is the first in which expression of a single gene in postnatal hair cells results in hair cell survival and hearing preservation in mice that otherwise suffer from age - related and noise - induced hearing loss,» Dr. Chen said.

Results from a statistical analysis shows a cluster of SNPs — single nucleotide polymorphisms — in one section of a single gene, indicating the location of a mutation likely linked to autism.

At the core of this cell behavior is how the loss of that single gene changes activation levels of dozens of other genes, suppressing genes associated with metastatic disease and increasing activity of genes linked to normal tissue.

The absence of a single gene tree identical to the avian species tree is consistent with studies in yeast (82), indicating that phylogenetic studies based on one or several genes, especially for rapid radiations, will probably be insufficient.

It can take up to a year to determine the function of a single gene, which has slowed efforts to develop new, more targeted drugs and vaccines.

To make BinoX directly usable for other researchers, a public web server http://PathwaX.sbc.su.se (Ogris et al., 2016b) was set up for on - line pathway analysis of single gene sets, which applies the BinoX algorithm to all KEGG pathways and FunCoup networks.

«But it's remarkable that lowering levels of a single gene could have such a strong effect on the disease.

Now, a study led by a researcher at the Salk Institute has found that variants of a single gene can largely determine a plant's ability to thrive in environments where iron is scarce.

«So, the flexibility of yeast cells does not arise from the activity or inactivity of a single gene,» project head at ISB, Dr. Aimée Dudley, explains.

Changing the epigenetic code of a single gene is enough to cause a healthy breast cell to begin a chain reaction and become abnormal, according to research by Queen Mary University of London (QMUL).

Promiscuous male voles can be turned into paragons of monogamous virtue simply by increasing the expression of a single gene.

Now, with the addition of a single gene, rice can be cultivated to emit virtually no methane from its paddies during growth.

Thus I was able to ask how the expression of this single gene limits the size of the haltere.

Changes in the regulatory region of a single gene may have had a profound affect on human evolution.

But an alternative explanation is that inheriting recessive copies of a single gene from both parents often, but not always, causes the disorder.

First, unlike CRISPR, the AAV - based approach is only able to target a single allele of a single gene at once.

Around 2.5 million years ago, the erroneous duplication of a single gene changed the course of our brains» evolution forever.

«So there could be a large effect of a single gene, but there is some other factor necessary for developing disease,» says Richard Lifton at Yale University, Connecticut, US, who led the new research.

Single gene PDG: Helping carriers of single gene disorders have a successful pregnancy and a healthy baby.

While his previous method relied almost entirely on small molecules, it still included a minute amount of genetic manipulation; that is, he often required the use of a single gene to enhance his chemical cocktails.

Nonetheless, building a user - friendly device that allows scientists to track the activity of a single gene in all cell types over the course of a plant's life cycle is a tall order.

By getting back to basics, they reasoned, scientists might stand a chance of actually understanding the purpose of every single gene in a living cell.

Five to 10 years ago, the sequencing of a single gene was often sufficient to get a scientist's work published in a prestigious journal.

The Hopkins scientists report that the loss of a single gene in kidney cancer cells causes them to stop making mitochondria, the tiny powerhouses of the cell that consume oxygen to generate energy.

All with the snip of a single gene.

The unintended consequence of a single gene change pale in comparison to the negative health consequences of the intensive inbreeding required to produce the extreme physical features of the fad breeds of today.

Not exact matches

Even though there's no single «morning person gene» the results indicate that your love of the snooze button isn't entirely down to laziness, personal choice or your environment.

That's because, in theory, thanks to that single wisp of intermediate code, the genes implicated in many diseases should be easier to quiet.

Microbes could load these donated genes together on a single piece of DNA, accelerating the spread of resistance even further.

(insert your own, southerners backwoods joke here) So Mendel fails, in my mind, to adequately account for the very narrow gene pool (read single - celled organism) that the theory of evolution begins with.