Sentences with phrase «of single genes in»

Teasing out the effect of single genes in deafness is difficult.

The loss of a single gene in mice can affect social behavior and impair their brains» ability to filter out distractions — both characteristics of several neurological diseases in humans.

«To our knowledge, our model is the first in which expression of a single gene in postnatal hair cells results in hair cell survival and hearing preservation in mice that otherwise suffer from age - related and noise - induced hearing loss,» Dr. Chen said.

Nonetheless, building a user - friendly device that allows scientists to track the activity of a single gene in all cell types over the course of a plant's life cycle is a tall order.

By getting back to basics, they reasoned, scientists might stand a chance of actually understanding the purpose of every single gene in a living cell.

The Hopkins scientists report that the loss of a single gene in kidney cancer cells causes them to stop making mitochondria, the tiny powerhouses of the cell that consume oxygen to generate energy.

Not exact matches

Here's why: In the late 90s, technology emerged enabling researchers to rapidly sequence RNA and DNA — giving them the ability to isolate and record the activity of single genes.

That's because, in theory, thanks to that single wisp of intermediate code, the genes implicated in many diseases should be easier to quiet.

(insert your own, southerners backwoods joke here) So Mendel fails, in my mind, to adequately account for the very narrow gene pool (read single - celled organism) that the theory of evolution begins with.

An article in New Scientist (12 May 2012) explored the fact that a double mutation of a single gene seems to have taken place about 2.5 million years ago, beginning the separation of homo from Australopithecus.

Blakemore argues that a single gene mutation could in fact have been the cause of this increase - for in fact only one extra cell - division step would cause a doubling of brain size.

But, as journalist Steve Connor reports, the reference to editing was intentional: «Scientists have used the genome - editing technology to cure adult laboratory mice of an inherited liver disease by correcting a single «letter» of the genetic alphabet which had been mutated in a vital gene involved in liver metabolism.»

According to a source with knowledge of the Attorney General's plans, tomorrow Eric Schneiderman will file suit against New York City taxi magnate Evgeny «Gene» Freidman, the single largest holder of medallions in the city.

No particular genetic variant was shared across all synesthetes in all three families, suggesting there is no single «synesthesia gene» or set of genes.

Lacking money to outfit the new lab, Wang and Xin bought used equipment: a single channel DNA sequencer (bought and barely touched by a Harvard Medical School researcher); second - hand centrifuges and pipettes; a reconditioned CytoScan HD system that detects variations in the number of copies of a gene.

Some morphogenic gradients apparently yield but a single effect: If the concentration of a morphogen in a particular place is above a critical threshold, a target gene is activated; otherwise, it is not.

In SIF - seq, hundreds or thousands of DNA fragments to be tested for enhancer activity are coupled to a reporter gene and targeted into a single, reproducible site in embryonic cell genomeIn SIF - seq, hundreds or thousands of DNA fragments to be tested for enhancer activity are coupled to a reporter gene and targeted into a single, reproducible site in embryonic cell genomein embryonic cell genomes.

New research at the University at Buffalo reveals the first evidence that it may be possible to use a single compound to alleviate the behavioral symptoms by targeting sets of genes involved in the disease.

In 1986 my research group at the Rockefeller University and another led by Jeffrey Hall of Brandeis University and Michael Rosbash of the Howard Hughes Medical Institute at Brandeis found that the three mutant flies had three different alterations in a single gene named period, or per, which each of our teams had independently isolated two years earlieIn 1986 my research group at the Rockefeller University and another led by Jeffrey Hall of Brandeis University and Michael Rosbash of the Howard Hughes Medical Institute at Brandeis found that the three mutant flies had three different alterations in a single gene named period, or per, which each of our teams had independently isolated two years earliein a single gene named period, or per, which each of our teams had independently isolated two years earlier.

In fact, no single gene or group of genes supports the idea of race.

In yeast, for example, they've found that increasing the activity of a single gene, called Sir2, can significantly extend life span.

The disease results from a single mutation in the gene that codes for one of the protein chains that make up the hemoglobin molecule.

Alpha -1-antitrypsin deficiency (A1ATD) is the most common genetic disease of the liver, and is caused by a single nucleotide change in the gene that codes for alpha -1-antitrypsin (A1AT), an enzyme inhibitor that normally protects bodily tissues.

With a single local injection of the USH1G gene just after birth, the scientists observed a restoration of the structure and mechanosensory function of the inner ear hair bundles — profoundly damaged before birth -, resulting in a long - term partial recovery of hearing, and complete recovery of vestibular function in these mice.

To generate the models, Jackson created two mutated versions of the PrP - coding gene by changing a single codon — one of the three - nucleotide «words» in genes that code for the various amino acids in proteins.

The paper was a landmark, demonstrating «that a single gene mutation in the mouse could extend life span,» says gerontologist Richard Miller of the University of Michigan Geriatrics Center in Ann Arbor.

In the new study, the researchers sequenced the entire genome of mice that had undergone CRISPR gene editing in the team's previous study and looked for all mutations, including those that only altered a single nucleotidIn the new study, the researchers sequenced the entire genome of mice that had undergone CRISPR gene editing in the team's previous study and looked for all mutations, including those that only altered a single nucleotidin the team's previous study and looked for all mutations, including those that only altered a single nucleotide.

In these and other inherited diseases, 10 to 15 percent of the single - base pair mutations that cause the disease create a misplaced, premature «stop» codon in the middle of the gene — causing the machinery of the cell to prematurely halt synthesis of the protein, which destroys its ability to functioIn these and other inherited diseases, 10 to 15 percent of the single - base pair mutations that cause the disease create a misplaced, premature «stop» codon in the middle of the gene — causing the machinery of the cell to prematurely halt synthesis of the protein, which destroys its ability to functioin the middle of the gene — causing the machinery of the cell to prematurely halt synthesis of the protein, which destroys its ability to function.

Their preliminary analysis revealed several mutations known as single nucleotide polymorphisms (SNPs) in the ALR gene, many of which haven't been identified before.

The hypocretin receptor 2 gene could be the single most important gene in human narcolepsy, says Michael Aldrich, a neurologist and director of the University of Michigan's Sleep Disorders Center.

The researchers determined that CRISPR had successfully corrected a gene that causes blindness, but Kellie Schaefer, a PhD student in the lab of Vinit Mahajan, MD, PhD, associate professor of ophthalmology at Stanford University, and co-author of the study, found that the genomes of two independent gene therapy recipients had sustained more than 1,500 single - nucleotide mutations and more than 100 larger deletions and insertions.

Scientists have shifted from studying single molecules to investigating large complexes of interacting biological macromolecules involved in processes such as metabolic pathways, gene expression, and development of disease.

Rare mutations that shut down a single gene are linked to lower cholesterol levels and a 50 percent reduction in the risk of heart attack, according to new research from Washington University School of Medicine in St. Louis, the Broad Institute at Massachusetts Institute of Technology and Harvard, and other institutions.

Working with this hypothesis, the researchers conducted a statistical analysis of the CX3CR1 gene in over 7000 schizophrenia and autism patients and healthy subjects, finding one mutant candidate, a single amino acid switch from alanine to threonine, as a candidate marker for prediction.

Tadashi Matsunaga at the Tokyo University of Agriculture and Technology in Japan and his colleagues singled out the genes by comparing well - known magnetic bacteria to a distantly related magnetic species.

Previous studies in nearly 3000 HIV - infected people had failed to uncover a single person who had inherited copies of the mutated gene that produces the CCR5 protein from both parents.

Patients with Parkinson's disease may be the first group to benefit from gene therapy, the much hyped technique that has yet to result in a single reliable treatment despite nearly two decades of experimentation.

Unlike other autoimmune disorders with associated risk factors, APECED is clearly caused by a mutation in a single gene, based on analyses of affected families.

In these mutants, or Frankenflies, a single gene could put legs on the head in place of antennaIn these mutants, or Frankenflies, a single gene could put legs on the head in place of antennain place of antennae.

In the intervening years, we have come to realize that many of the most interesting and important phenomena in human biology are not caused by any single genIn the intervening years, we have come to realize that many of the most interesting and important phenomena in human biology are not caused by any single genin human biology are not caused by any single gene.

«When most people think about cancer genetics, they think about single key mutations that foster tumor formation — very specific things like the BRCA genes,» said Joe R. Delaney, PhD, a fellow in the Clinical Translation program at UC San Diego Moores Cancer Center and lead author of the paper published February 15 in Nature Communications.

Using a combination of old - fashioned clinical observation and modern biochemical analysis, he has shown that a person's appetite and their eating behavior can be linked to specific genes — and that even a tiny defect such as the absence of a single nucleic acid in a sequence of DNA can lead to runaway weight gain.

The researchers assessed LPLD - related acute abdominal events that required hospital care in a small group of patients treated with a single dose of the gene therapy product Glybera ®.

A mutation in the LRRK2 gene is the single most common inherited cause of Parkinson's disease.

In the U.S., this behavioral division follows a genetic one: workers bearing two copies of one form, or allele, of the Gp - 9 gene live in nests governed by a single matriarch, whereas those that have one copy or a pair of a second allele take orders from a female oligarchIn the U.S., this behavioral division follows a genetic one: workers bearing two copies of one form, or allele, of the Gp - 9 gene live in nests governed by a single matriarch, whereas those that have one copy or a pair of a second allele take orders from a female oligarchin nests governed by a single matriarch, whereas those that have one copy or a pair of a second allele take orders from a female oligarchy.

In 1993 she proved that turning down the expression of a single gene, daf - 2, through genetic engineering doubled the worm's life span.

The two studies together suggest that single copies of inactivating ANGPTL3 mutations are found in roughly one of every 250 people of European descent, whereas people with mutations in both copies of the gene — as in the family studied by Musunuru and colleagues — are much rarer.

Inheriting a single X chromosome exposes men to a host of X-linked diseases, such as hemophilia or Duchenne muscular dystrophy, and researchers hope to use the new data to understand more fully the role of genes in other X-linked conditions.

Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth's Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk - associated with disease than protective.

The MGH investigators screened the genomes of 40 individuals with arhinia and 55 family members, from a total of 38 families, revealing rare single - nucleotide mutations within the SMCHD1 gene in 84 percent of affected individuals.