Sentences with phrase «of single genes with»

Conditional expression of hairpin constructs in Drosophila is a powerful method to disrupt the activity of single genes with a spatial and temporal resolution that is impossible, or exceedingly difficult, using classical genetic methods.

Not exact matches

(insert your own, southerners backwoods joke here) So Mendel fails, in my mind, to adequately account for the very narrow gene pool (read single - celled organism) that the theory of evolution begins with.

According to a source with knowledge of the Attorney General's plans, tomorrow Eric Schneiderman will file suit against New York City taxi magnate Evgeny «Gene» Freidman, the single largest holder of medallions in the city.

Just as with modern Homo sapiens, the genome of a single individual can not tell us exactly what genes and traits are specific to all Denisovans.

With a single local injection of the USH1G gene just after birth, the scientists observed a restoration of the structure and mechanosensory function of the inner ear hair bundles — profoundly damaged before birth -, resulting in a long - term partial recovery of hearing, and complete recovery of vestibular function in these mice.

Working with this hypothesis, the researchers conducted a statistical analysis of the CX3CR1 gene in over 7000 schizophrenia and autism patients and healthy subjects, finding one mutant candidate, a single amino acid switch from alanine to threonine, as a candidate marker for prediction.

Patients with Parkinson's disease may be the first group to benefit from gene therapy, the much hyped technique that has yet to result in a single reliable treatment despite nearly two decades of experimentation.

Unlike other autoimmune disorders with associated risk factors, APECED is clearly caused by a mutation in a single gene, based on analyses of affected families.

The researchers assessed LPLD - related acute abdominal events that required hospital care in a small group of patients treated with a single dose of the gene therapy product Glybera ®.

The two studies together suggest that single copies of inactivating ANGPTL3 mutations are found in roughly one of every 250 people of European descent, whereas people with mutations in both copies of the gene — as in the family studied by Musunuru and colleagues — are much rarer.

Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth's Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk - associated with disease than protective.

The MGH investigators screened the genomes of 40 individuals with arhinia and 55 family members, from a total of 38 families, revealing rare single - nucleotide mutations within the SMCHD1 gene in 84 percent of affected individuals.

It cost them about $ 900 to knock out a single gene in a group of Parhyale embryos with their other method.

«There is no single magic bullet that will solve all the problems associated with gene therapy,» says Elizabeth Nabel, a cardiologist at the University of Michigan, Ann Arbor.

The tool acts with surgical precision to replace only abundances that have most likely dropped out and can be used in any type of single - cell gene - expression analysis.

The results of the study were obtained by infecting laboratory - grown cells with forms of the CMV virus which differed only by the removal of a single gene.

Within a single tumor exists such an astonishingly varied population of cells, each with its own combination of normal and abnormal genes, that at least some cells nearly always have a way to survive any particular attack.

Starting with a candidate list of 20,000 genes, researchers screened down to eight before singling out VNN - 1 as the primary target.

In a paper published in Nature Methods, postdoctoral fellows Naomi Habib, Inbal Avraham - Davidi, and Anindita Basu; core institute members Feng Zhang and Aviv Regev; and their colleagues reveal DroNc - Seq, a single - cell expression profiling technique that merges sNuc - Seq with microfluidics, allowing massively parallel measurement of gene expression in structurally - complicated tissues.

RNA sequencing of both single and clustered CTCs from breast cancer patients identified several genes expressed at elevated levels in CTC clusters, one of which — a protein called plakoglobin — also was overexpressed in the primary tumors of patients with reduced survival.

Pinker says that the findings are a first step in demonstrating that intelligence relies on large numbers of genes, each with a tiny effect, rather than on single genes that have moderate or large effects, but which are so rare that none has yet been identified.

Rare, deadly, and caused by a single gene mutation, it was a perfect proof - of - principle condition for anyone seeking to replace damaged DNA with genes that did the job.

In many cases, the activity of particular genes was tied to a single genetic variant, with strong differences in frequency between European and African populations.

With the data provided by the FLI researchers, scientists around the world may now set targeted mutations to investigate the relevance of single genes for aging, in order to better understand regulating mechanisms and, eventually, develop new approaches for therapy or prevention of aging - related diseases.

Labs have started tackling the problem with a tool called single - cell transcriptome analysis, which gives readouts of all the genes that are active in individual cells.

But not a single country had yet approved cultivation of a major food crop equipped with new genes.

For Helicobacter pylori, a pathogenic bacterium that colonizes over 40 percent of the world population and is associated with gastric cancer, the team discovered that epigenetic heterogeneity can quickly emerge as a single cell divides, and different subpopulations with distinct methylation patterns have distinct gene expressions patterns.

Once again, they saw that methylation of a single spot in the serotonin transporter gene was associated with lower levels of serotonin transporter expression in the amygdala.

At the core of this cell behavior is how the loss of that single gene changes activation levels of dozens of other genes, suppressing genes associated with metastatic disease and increasing activity of genes linked to normal tissue.

With just a bit of hindbrain and a flap of ear where the head should be, the mouse pup is a freak of science — but it is also the first proof that a single gene plays an essential role in creating a head.

«For the first time, we can predict the outcomes of modifying multiple genes involved in lignin biosynthesis, rather than working with a single gene at a time through trial and error, which is a tedious and time - consuming process,» says Jack Wang, assistant professor in NC State's College of Natural Resources and lead author of a paper about the research in Nature Communications.

And the mutations that maybe two genes regulated differently — we gathered various sorts of hints that those mutations couldn't have happened with just a single gene.

When a single gene exists in the ancestral mutation, that would have made for higher levels of enzyme expression, would have messed up with sensory function.

In this episode, Scientific American news editor Phil Yam discusses how veterinarians, physicians and multinational food companies need to work together in the global fight against animal - borne infectious diseases; and University of Wisconsin evolutionary biologist Sean Carroll talks about recent research tracking the evolution of yeast genes with specific functions descended from a single, duplicated gene with multiple functions.

Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (effector memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T cells in the central memory (TCM) and effector memory (TEM) subsets.

With the completion of the first phase of the Human Genome Project in 2000, and the advent of sequencing technologies that can detect gene variations such as single nucleotide polymorphisms (SNPs), for the first time scientists have the tools in hand to find the key immune genes and genetic networks that play roles in vaccine response.

The team found that a single polymorphism (a difference in one «letter» of the sequence) in the BDNF gene accounted for significant differences in intelligence among those with similar injuries and comparable intelligence before being injured.

The genomics era has had a profound impact on life science research, leading to significant developments such as the use of expression quantitative trait loci (eQTLs), which link polymorphisms in single genes to quantifiable changes in gene expression associated with specific diseases.

«For the first time we've found that almost every complex disease has a unique set of associations with single - gene diseases.

About 10 to 15 percent of people with autism have a disorder linked to a known single - gene mutation, such as fragile X syndrome, or chromosomal alterations.

Pea plants with a single nucleotide mutation in the gene produce a sluggish form of the enzyme and consequently grow short.

Not only would it be enormously difficult to manipulate so many genes in a single person, but scientists would still have to reckon with the even more complicated matter of how the environment influences those genes.

He has worked in the biotech industry as a research scientist for over 11 years with a focus on emerging technologies including gene targeting in mice, molecular analysis of transgenes using GFP variants at the single cell level, and developing flow cytometry reagent kits to speed up assay development time for researchers.

«This methodology is very important because it allows you to very quickly integrate almost any piece of DNA in these vectors,» remarks Bellen, who says this technology also allows scientists to put single point mutations in a gene and then reinsert the gene into a genome as well as tagging a segment of DNA with fluorescent markers.

Others might be engineered to include nutrients like beta carotene, iron, and vitamin A. Instead of one gene to fight off insects or disease, crops will be engineered with «stacks» of resistance genes to prevent pests from evolving resistance to a single approach.

The absence of a single gene tree identical to the avian species tree is consistent with studies in yeast (82), indicating that phylogenetic studies based on one or several genes, especially for rapid radiations, will probably be insufficient.

Last autumn Jean Weissenbach and Marc Lathrop came up with a new type of genetic map which makes it possible to map most single genes in «months instead of years», according to Nigel Spurr, a cancer researcher and gene mapper at the Imperial Cancer Research Fund.

An alteration in the neuregulin - 1 gene — a single change in one letter of the DNA code for the protein — has been found in families with schizophrenia and linked to late - onset Alzheimer's disease with psychosis.

This more complete set of protein - coding genes still did not have a single estimated gene tree that was fully congruent with the ExaML or MP - EST * TENT trees (fig.

Instead, Werren likened the functionality of these single - copy genes to «moonlighting» for extra cash, with the genes taking on a «night job» in the venom gland in addition to their «day job» elsewhere in the body.